Julien Duxin

Julien Duxin

Associate professor, group leader

  • Duxin Group

    Blegdamsvej 3, 2200 København N, Bygning 6, Building: 06-3-32

    Phone: +45 35 32 07 31Mobile: +45 93 56 55 71

Julien Duxin’s research focuses in understanding basic mechanisms of genome maintenance using Xenopus egg extracts as a model system. Particularly, he studies how DNA lesions induced by chemotherapeutic agents are repaired. This has led to the first system that recapitulates DNA-protein crosslink (DPCs) repair in vitro (Duxin et al. Cell, 2014). This initial discovery opened an entire new area of investigation, highly relevant to human health as DPC-inducers are commonly used in the clinic to treat cancer. Julien’s lab is now investigating how DPC-repair is intrinsically linked to DNA replication and interrogating which are the main players orchestrating the repair reaction (Larsen et al. Molecular Cell, 2018). His ultimate goal is to unravel new molecular mechanisms of DNA repair and identify novel chemotherapeutic targets that could be used in the clinic to sensitize patients to commonly used anti-cancer drugs.

Selected publications

  1. Published

    A safe fix for alcohol-derived DNA damage: [Alcohol-derived DNA damage fixed in two ways]

    Gallina, Irene & Duxin, Julien, 2020, In : Nature. 579, 7800, p. 499-500 2 p.

    Research output: Contribution to journalComment/debateResearch

  2. Published

    Replication-Coupled DNA-Protein Crosslink Repair by SPRTN and the Proteasome in Xenopus Egg Extracts

    Larsen, N. B., Gao, A. O., Sparks, J. L., Gallina, Irene, Wu, R. A., Mann, Matthias, Räschle, M., Walter, J. C. & Duxin, Julien, 2019, In : Molecular Cell. 73, 3, p. 574-588.e7 23 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    The CMG Helicase Bypasses DNA-Protein Cross-Links to Facilitate Their Repair

    Sparks, J. L., Chistol, G., Gao, A. O., Räschle, M., Larsen, N. B., Mann, Matthias, Duxin, Julien & Walter, J. C., 2019, In : Cell. 176, 1-2, p. 167-181.e21

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. What is the DNA repair defect underlying Fanconi anemia?

    Duxin, Julien & Walter, J. C., Dec 2015, In : Current Opinion in Cell Biology. 37, p. 49-60 12 p.

    Research output: Contribution to journalReviewResearchpeer-review

  5. Repair of a DNA-protein crosslink by replication-coupled proteolysis

    Duxin, Julien, Dewar, J. M., Yardimci, H. & Walter, J. C., 9 Oct 2014, In : Cell. 159, 2, p. 346-57 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Okazaki fragment processing-independent role for human Dna2 enzyme during DNA replication

    Duxin, Julien, Moore, H. R., Sidorova, J., Karanja, K. K., Honaker, Y., Dao, B., Piwnica-Worms, H., Campbell, J. L., Monnat, R. J. & Stewart, S. A., 22 Jun 2012, In : The Journal of Biological Chemistry. 287, 26, p. 21980-91 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. DNA2 and EXO1 in replication-coupled, homology-directed repair and in the interplay between HDR and the FA/BRCA network

    Karanja, K. K., Cox, S. W., Duxin, Julien, Stewart, S. A. & Campbell, J. L., 1 Nov 2012, In : Cell Cycle. 11, 21, p. 3983-96 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Human Dna2 is a nuclear and mitochondrial DNA maintenance protein

    Duxin, Julien, Dao, B., Martinsson, P., Rajala, N., Guittat, L., Campbell, J. L., Spelbrink, J. N. & Stewart, S. A., Aug 2009, In : Molecular and Cellular Biology. 29, 15, p. 4274-82 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 164085189