Unexplored therapeutic opportunities in the human genome
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Unexplored therapeutic opportunities in the human genome. / Oprea, Tudor I; Bologa, Cristian G; Brunak, Søren; Campbell, Allen; Gan, Gregory N; Gaulton, Anna; Gomez, Shawn M; Guha, Rajarshi; Hersey, Anne; Holmes, Jayme; Jadhav, Ajit; Jensen, Lars Juhl; Johnson, Gary L; Karlson, Anneli; Leach, Andrew R; Ma'ayan, Avi; Malovannaya, Anna; Mani, Subramani; Mathias, Stephen L; McManus, Michael T; Meehan, Terrence F; von Mering, Christian; Muthas, Daniel; Nguyen, Dac-Trung; Overington, John P; Papadatos, George; Qin, Jun; Reich, Christian; Roth, Bryan L; Schürer, Stephan C; Simeonov, Anton; Sklar, Larry A; Southall, Noel; Tomita, Susumu; Tudose, Ilinca; Ursu, Oleg; Vidovic, Dušica; Waller, Anna; Westergaard, David; Yang, Jeremy J; Zahoránszky-Köhalmi, Gergely.
In: Nature Reviews. Drug Discovery, Vol. 17, No. 5, 2018, p. 317-332.Research output: Contribution to journal › Review › peer-review
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TY - JOUR
T1 - Unexplored therapeutic opportunities in the human genome
AU - Oprea, Tudor I
AU - Bologa, Cristian G
AU - Brunak, Søren
AU - Campbell, Allen
AU - Gan, Gregory N
AU - Gaulton, Anna
AU - Gomez, Shawn M
AU - Guha, Rajarshi
AU - Hersey, Anne
AU - Holmes, Jayme
AU - Jadhav, Ajit
AU - Jensen, Lars Juhl
AU - Johnson, Gary L
AU - Karlson, Anneli
AU - Leach, Andrew R
AU - Ma'ayan, Avi
AU - Malovannaya, Anna
AU - Mani, Subramani
AU - Mathias, Stephen L
AU - McManus, Michael T
AU - Meehan, Terrence F
AU - von Mering, Christian
AU - Muthas, Daniel
AU - Nguyen, Dac-Trung
AU - Overington, John P
AU - Papadatos, George
AU - Qin, Jun
AU - Reich, Christian
AU - Roth, Bryan L
AU - Schürer, Stephan C
AU - Simeonov, Anton
AU - Sklar, Larry A
AU - Southall, Noel
AU - Tomita, Susumu
AU - Tudose, Ilinca
AU - Ursu, Oleg
AU - Vidovic, Dušica
AU - Waller, Anna
AU - Westergaard, David
AU - Yang, Jeremy J
AU - Zahoránszky-Köhalmi, Gergely
PY - 2018
Y1 - 2018
N2 - A large proportion of biomedical research and the development of therapeutics is focused on a small fraction of the human genome. In a strategic effort to map the knowledge gaps around proteins encoded by the human genome and to promote the exploration of currently understudied, but potentially druggable, proteins, the US National Institutes of Health launched the Illuminating the Druggable Genome (IDG) initiative in 2014. In this article, we discuss how the systematic collection and processing of a wide array of genomic, proteomic, chemical and disease-related resource data by the IDG Knowledge Management Center have enabled the development of evidence-based criteria for tracking the target development level (TDL) of human proteins, which indicates a substantial knowledge deficit for approximately two out of five proteins in the human proteome. We then present spotlights on the TDL categories as well as key drug target classes, including G protein-coupled receptors, protein kinases and ion channels, which illustrate the nature of the unexplored opportunities for biomedical research and therapeutic development.
AB - A large proportion of biomedical research and the development of therapeutics is focused on a small fraction of the human genome. In a strategic effort to map the knowledge gaps around proteins encoded by the human genome and to promote the exploration of currently understudied, but potentially druggable, proteins, the US National Institutes of Health launched the Illuminating the Druggable Genome (IDG) initiative in 2014. In this article, we discuss how the systematic collection and processing of a wide array of genomic, proteomic, chemical and disease-related resource data by the IDG Knowledge Management Center have enabled the development of evidence-based criteria for tracking the target development level (TDL) of human proteins, which indicates a substantial knowledge deficit for approximately two out of five proteins in the human proteome. We then present spotlights on the TDL categories as well as key drug target classes, including G protein-coupled receptors, protein kinases and ion channels, which illustrate the nature of the unexplored opportunities for biomedical research and therapeutic development.
U2 - 10.1038/nrd.2018.14
DO - 10.1038/nrd.2018.14
M3 - Review
C2 - 29472638
VL - 17
SP - 317
EP - 332
JO - Nature Reviews. Drug Discovery
JF - Nature Reviews. Drug Discovery
SN - 1474-1776
IS - 5
ER -
ID: 191215108