Unexplored therapeutic opportunities in the human genome

Research output: Contribution to journalReviewResearchpeer-review

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Unexplored therapeutic opportunities in the human genome. / Oprea, Tudor I; Bologa, Cristian G; Brunak, Søren; Campbell, Allen; Gan, Gregory N; Gaulton, Anna; Gomez, Shawn M; Guha, Rajarshi; Hersey, Anne; Holmes, Jayme; Jadhav, Ajit; Jensen, Lars Juhl; Johnson, Gary L; Karlson, Anneli; Leach, Andrew R; Ma'ayan, Avi; Malovannaya, Anna; Mani, Subramani; Mathias, Stephen L; McManus, Michael T; Meehan, Terrence F; von Mering, Christian; Muthas, Daniel; Nguyen, Dac-Trung; Overington, John P; Papadatos, George; Qin, Jun; Reich, Christian; Roth, Bryan L; Schürer, Stephan C; Simeonov, Anton; Sklar, Larry A; Southall, Noel; Tomita, Susumu; Tudose, Ilinca; Ursu, Oleg; Vidovic, Dušica; Waller, Anna; Westergaard, David; Yang, Jeremy J; Zahoránszky-Köhalmi, Gergely.

In: Nature Reviews. Drug Discovery, Vol. 17, No. 5, 2018, p. 317-332.

Research output: Contribution to journalReviewResearchpeer-review

Harvard

Oprea, TI, Bologa, CG, Brunak, S, Campbell, A, Gan, GN, Gaulton, A, Gomez, SM, Guha, R, Hersey, A, Holmes, J, Jadhav, A, Jensen, LJ, Johnson, GL, Karlson, A, Leach, AR, Ma'ayan, A, Malovannaya, A, Mani, S, Mathias, SL, McManus, MT, Meehan, TF, von Mering, C, Muthas, D, Nguyen, D-T, Overington, JP, Papadatos, G, Qin, J, Reich, C, Roth, BL, Schürer, SC, Simeonov, A, Sklar, LA, Southall, N, Tomita, S, Tudose, I, Ursu, O, Vidovic, D, Waller, A, Westergaard, D, Yang, JJ & Zahoránszky-Köhalmi, G 2018, 'Unexplored therapeutic opportunities in the human genome', Nature Reviews. Drug Discovery, vol. 17, no. 5, pp. 317-332. https://doi.org/10.1038/nrd.2018.14

APA

Oprea, T. I., Bologa, C. G., Brunak, S., Campbell, A., Gan, G. N., Gaulton, A., ... Zahoránszky-Köhalmi, G. (2018). Unexplored therapeutic opportunities in the human genome. Nature Reviews. Drug Discovery, 17(5), 317-332. https://doi.org/10.1038/nrd.2018.14

Vancouver

Oprea TI, Bologa CG, Brunak S, Campbell A, Gan GN, Gaulton A et al. Unexplored therapeutic opportunities in the human genome. Nature Reviews. Drug Discovery. 2018;17(5):317-332. https://doi.org/10.1038/nrd.2018.14

Author

Oprea, Tudor I ; Bologa, Cristian G ; Brunak, Søren ; Campbell, Allen ; Gan, Gregory N ; Gaulton, Anna ; Gomez, Shawn M ; Guha, Rajarshi ; Hersey, Anne ; Holmes, Jayme ; Jadhav, Ajit ; Jensen, Lars Juhl ; Johnson, Gary L ; Karlson, Anneli ; Leach, Andrew R ; Ma'ayan, Avi ; Malovannaya, Anna ; Mani, Subramani ; Mathias, Stephen L ; McManus, Michael T ; Meehan, Terrence F ; von Mering, Christian ; Muthas, Daniel ; Nguyen, Dac-Trung ; Overington, John P ; Papadatos, George ; Qin, Jun ; Reich, Christian ; Roth, Bryan L ; Schürer, Stephan C ; Simeonov, Anton ; Sklar, Larry A ; Southall, Noel ; Tomita, Susumu ; Tudose, Ilinca ; Ursu, Oleg ; Vidovic, Dušica ; Waller, Anna ; Westergaard, David ; Yang, Jeremy J ; Zahoránszky-Köhalmi, Gergely. / Unexplored therapeutic opportunities in the human genome. In: Nature Reviews. Drug Discovery. 2018 ; Vol. 17, No. 5. pp. 317-332.

Bibtex

@article{2703de077de040638d06dd6ab03147af,
title = "Unexplored therapeutic opportunities in the human genome",
abstract = "A large proportion of biomedical research and the development of therapeutics is focused on a small fraction of the human genome. In a strategic effort to map the knowledge gaps around proteins encoded by the human genome and to promote the exploration of currently understudied, but potentially druggable, proteins, the US National Institutes of Health launched the Illuminating the Druggable Genome (IDG) initiative in 2014. In this article, we discuss how the systematic collection and processing of a wide array of genomic, proteomic, chemical and disease-related resource data by the IDG Knowledge Management Center have enabled the development of evidence-based criteria for tracking the target development level (TDL) of human proteins, which indicates a substantial knowledge deficit for approximately two out of five proteins in the human proteome. We then present spotlights on the TDL categories as well as key drug target classes, including G protein-coupled receptors, protein kinases and ion channels, which illustrate the nature of the unexplored opportunities for biomedical research and therapeutic development.",
author = "Oprea, {Tudor I} and Bologa, {Cristian G} and S{\o}ren Brunak and Allen Campbell and Gan, {Gregory N} and Anna Gaulton and Gomez, {Shawn M} and Rajarshi Guha and Anne Hersey and Jayme Holmes and Ajit Jadhav and Jensen, {Lars Juhl} and Johnson, {Gary L} and Anneli Karlson and Leach, {Andrew R} and Avi Ma'ayan and Anna Malovannaya and Subramani Mani and Mathias, {Stephen L} and McManus, {Michael T} and Meehan, {Terrence F} and {von Mering}, Christian and Daniel Muthas and Dac-Trung Nguyen and Overington, {John P} and George Papadatos and Jun Qin and Christian Reich and Roth, {Bryan L} and Sch{\"u}rer, {Stephan C} and Anton Simeonov and Sklar, {Larry A} and Noel Southall and Susumu Tomita and Ilinca Tudose and Oleg Ursu and Dušica Vidovic and Anna Waller and David Westergaard and Yang, {Jeremy J} and Gergely Zahor{\'a}nszky-K{\"o}halmi",
year = "2018",
doi = "10.1038/nrd.2018.14",
language = "English",
volume = "17",
pages = "317--332",
journal = "Nature Reviews. Drug Discovery",
issn = "1474-1776",
publisher = "nature publishing group",
number = "5",

}

RIS

TY - JOUR

T1 - Unexplored therapeutic opportunities in the human genome

AU - Oprea, Tudor I

AU - Bologa, Cristian G

AU - Brunak, Søren

AU - Campbell, Allen

AU - Gan, Gregory N

AU - Gaulton, Anna

AU - Gomez, Shawn M

AU - Guha, Rajarshi

AU - Hersey, Anne

AU - Holmes, Jayme

AU - Jadhav, Ajit

AU - Jensen, Lars Juhl

AU - Johnson, Gary L

AU - Karlson, Anneli

AU - Leach, Andrew R

AU - Ma'ayan, Avi

AU - Malovannaya, Anna

AU - Mani, Subramani

AU - Mathias, Stephen L

AU - McManus, Michael T

AU - Meehan, Terrence F

AU - von Mering, Christian

AU - Muthas, Daniel

AU - Nguyen, Dac-Trung

AU - Overington, John P

AU - Papadatos, George

AU - Qin, Jun

AU - Reich, Christian

AU - Roth, Bryan L

AU - Schürer, Stephan C

AU - Simeonov, Anton

AU - Sklar, Larry A

AU - Southall, Noel

AU - Tomita, Susumu

AU - Tudose, Ilinca

AU - Ursu, Oleg

AU - Vidovic, Dušica

AU - Waller, Anna

AU - Westergaard, David

AU - Yang, Jeremy J

AU - Zahoránszky-Köhalmi, Gergely

PY - 2018

Y1 - 2018

N2 - A large proportion of biomedical research and the development of therapeutics is focused on a small fraction of the human genome. In a strategic effort to map the knowledge gaps around proteins encoded by the human genome and to promote the exploration of currently understudied, but potentially druggable, proteins, the US National Institutes of Health launched the Illuminating the Druggable Genome (IDG) initiative in 2014. In this article, we discuss how the systematic collection and processing of a wide array of genomic, proteomic, chemical and disease-related resource data by the IDG Knowledge Management Center have enabled the development of evidence-based criteria for tracking the target development level (TDL) of human proteins, which indicates a substantial knowledge deficit for approximately two out of five proteins in the human proteome. We then present spotlights on the TDL categories as well as key drug target classes, including G protein-coupled receptors, protein kinases and ion channels, which illustrate the nature of the unexplored opportunities for biomedical research and therapeutic development.

AB - A large proportion of biomedical research and the development of therapeutics is focused on a small fraction of the human genome. In a strategic effort to map the knowledge gaps around proteins encoded by the human genome and to promote the exploration of currently understudied, but potentially druggable, proteins, the US National Institutes of Health launched the Illuminating the Druggable Genome (IDG) initiative in 2014. In this article, we discuss how the systematic collection and processing of a wide array of genomic, proteomic, chemical and disease-related resource data by the IDG Knowledge Management Center have enabled the development of evidence-based criteria for tracking the target development level (TDL) of human proteins, which indicates a substantial knowledge deficit for approximately two out of five proteins in the human proteome. We then present spotlights on the TDL categories as well as key drug target classes, including G protein-coupled receptors, protein kinases and ion channels, which illustrate the nature of the unexplored opportunities for biomedical research and therapeutic development.

U2 - 10.1038/nrd.2018.14

DO - 10.1038/nrd.2018.14

M3 - Review

C2 - 29472638

VL - 17

SP - 317

EP - 332

JO - Nature Reviews. Drug Discovery

JF - Nature Reviews. Drug Discovery

SN - 1474-1776

IS - 5

ER -

ID: 191215108