Transcriptional regulation is a major controller of cell cycle transition dynamics

Research output: Contribution to journalJournal articlepeer-review

Standard

Transcriptional regulation is a major controller of cell cycle transition dynamics. / Romanel, Alessandro; Jensen, Lars Juhl; Cardelli, Luca; Csikász-Nagy, Attila.

In: P L o S One, Vol. 7, No. 1, 2012, p. e29716.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Romanel, A, Jensen, LJ, Cardelli, L & Csikász-Nagy, A 2012, 'Transcriptional regulation is a major controller of cell cycle transition dynamics', P L o S One, vol. 7, no. 1, pp. e29716. https://doi.org/10.1371/journal.pone.0029716

APA

Romanel, A., Jensen, L. J., Cardelli, L., & Csikász-Nagy, A. (2012). Transcriptional regulation is a major controller of cell cycle transition dynamics. P L o S One, 7(1), e29716. https://doi.org/10.1371/journal.pone.0029716

Vancouver

Romanel A, Jensen LJ, Cardelli L, Csikász-Nagy A. Transcriptional regulation is a major controller of cell cycle transition dynamics. P L o S One. 2012;7(1):e29716. https://doi.org/10.1371/journal.pone.0029716

Author

Romanel, Alessandro ; Jensen, Lars Juhl ; Cardelli, Luca ; Csikász-Nagy, Attila. / Transcriptional regulation is a major controller of cell cycle transition dynamics. In: P L o S One. 2012 ; Vol. 7, No. 1. pp. e29716.

Bibtex

@article{8a5504906e974c86aed9741aaf2a561d,
title = "Transcriptional regulation is a major controller of cell cycle transition dynamics",
abstract = "DNA replication, mitosis and mitotic exit are critical transitions of the cell cycle which normally occur only once per cycle. A universal control mechanism was proposed for the regulation of mitotic entry in which Cdk helps its own activation through two positive feedback loops. Recent discoveries in various organisms showed the importance of positive feedbacks in other transitions as well. Here we investigate if a universal control system with transcriptional regulation(s) and post-translational positive feedback(s) can be proposed for the regulation of all cell cycle transitions. Through computational modeling, we analyze the transition dynamics in all possible combinations of transcriptional and post-translational regulations. We find that some combinations lead to 'sloppy' transitions, while others give very precise control. The periodic transcriptional regulation through the activator or the inhibitor leads to radically different dynamics. Experimental evidence shows that in cell cycle transitions of organisms investigated for cell cycle dependent periodic transcription, only the inhibitor OR the activator is under cyclic control and never both of them. Based on these observations, we propose two transcriptional control modes of cell cycle regulation that either STOP or let the cycle GO in case of a transcriptional failure. We discuss the biological relevance of such differences.",
keywords = "Cell Cycle, Cell Cycle Checkpoints, Computational Biology, Computer Simulation, Gene Expression Regulation, Humans, Kinetics, Models, Biological, Schizosaccharomyces, Transcription Factors, Transcription, Genetic",
author = "Alessandro Romanel and Jensen, {Lars Juhl} and Luca Cardelli and Attila Csik{\'a}sz-Nagy",
year = "2012",
doi = "10.1371/journal.pone.0029716",
language = "English",
volume = "7",
pages = "e29716",
journal = "PLoS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "1",

}

RIS

TY - JOUR

T1 - Transcriptional regulation is a major controller of cell cycle transition dynamics

AU - Romanel, Alessandro

AU - Jensen, Lars Juhl

AU - Cardelli, Luca

AU - Csikász-Nagy, Attila

PY - 2012

Y1 - 2012

N2 - DNA replication, mitosis and mitotic exit are critical transitions of the cell cycle which normally occur only once per cycle. A universal control mechanism was proposed for the regulation of mitotic entry in which Cdk helps its own activation through two positive feedback loops. Recent discoveries in various organisms showed the importance of positive feedbacks in other transitions as well. Here we investigate if a universal control system with transcriptional regulation(s) and post-translational positive feedback(s) can be proposed for the regulation of all cell cycle transitions. Through computational modeling, we analyze the transition dynamics in all possible combinations of transcriptional and post-translational regulations. We find that some combinations lead to 'sloppy' transitions, while others give very precise control. The periodic transcriptional regulation through the activator or the inhibitor leads to radically different dynamics. Experimental evidence shows that in cell cycle transitions of organisms investigated for cell cycle dependent periodic transcription, only the inhibitor OR the activator is under cyclic control and never both of them. Based on these observations, we propose two transcriptional control modes of cell cycle regulation that either STOP or let the cycle GO in case of a transcriptional failure. We discuss the biological relevance of such differences.

AB - DNA replication, mitosis and mitotic exit are critical transitions of the cell cycle which normally occur only once per cycle. A universal control mechanism was proposed for the regulation of mitotic entry in which Cdk helps its own activation through two positive feedback loops. Recent discoveries in various organisms showed the importance of positive feedbacks in other transitions as well. Here we investigate if a universal control system with transcriptional regulation(s) and post-translational positive feedback(s) can be proposed for the regulation of all cell cycle transitions. Through computational modeling, we analyze the transition dynamics in all possible combinations of transcriptional and post-translational regulations. We find that some combinations lead to 'sloppy' transitions, while others give very precise control. The periodic transcriptional regulation through the activator or the inhibitor leads to radically different dynamics. Experimental evidence shows that in cell cycle transitions of organisms investigated for cell cycle dependent periodic transcription, only the inhibitor OR the activator is under cyclic control and never both of them. Based on these observations, we propose two transcriptional control modes of cell cycle regulation that either STOP or let the cycle GO in case of a transcriptional failure. We discuss the biological relevance of such differences.

KW - Cell Cycle

KW - Cell Cycle Checkpoints

KW - Computational Biology

KW - Computer Simulation

KW - Gene Expression Regulation

KW - Humans

KW - Kinetics

KW - Models, Biological

KW - Schizosaccharomyces

KW - Transcription Factors

KW - Transcription, Genetic

U2 - 10.1371/journal.pone.0029716

DO - 10.1371/journal.pone.0029716

M3 - Journal article

C2 - 22238641

VL - 7

SP - e29716

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

IS - 1

ER -

ID: 40290850