The SIDER database of drugs and side effects

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

The SIDER database of drugs and side effects. / Kuhn, Michael; Letunic, Ivica; Jensen, Lars Juhl; Bork, Peer.

In: Nucleic Acids Research, Vol. 44, 04.01.2016, p. D1075-9.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Kuhn, M, Letunic, I, Jensen, LJ & Bork, P 2016, 'The SIDER database of drugs and side effects', Nucleic Acids Research, vol. 44, pp. D1075-9. https://doi.org/10.1093/nar/gkv1075

APA

Kuhn, M., Letunic, I., Jensen, L. J., & Bork, P. (2016). The SIDER database of drugs and side effects. Nucleic Acids Research, 44, D1075-9. https://doi.org/10.1093/nar/gkv1075

Vancouver

Kuhn M, Letunic I, Jensen LJ, Bork P. The SIDER database of drugs and side effects. Nucleic Acids Research. 2016 Jan 4;44:D1075-9. https://doi.org/10.1093/nar/gkv1075

Author

Kuhn, Michael ; Letunic, Ivica ; Jensen, Lars Juhl ; Bork, Peer. / The SIDER database of drugs and side effects. In: Nucleic Acids Research. 2016 ; Vol. 44. pp. D1075-9.

Bibtex

@article{c3de0b77f0e7470ea68548f9292eaddd,
title = "The SIDER database of drugs and side effects",
abstract = "Unwanted side effects of drugs are a burden on patients and a severe impediment in the development of new drugs. At the same time, adverse drug reactions (ADRs) recorded during clinical trials are an important source of human phenotypic data. It is therefore essential to combine data on drugs, targets and side effects into a more complete picture of the therapeutic mechanism of actions of drugs and the ways in which they cause adverse reactions. To this end, we have created the SIDER ('Side Effect Resource', http://sideeffects.embl.de) database of drugs and ADRs. The current release, SIDER 4, contains data on 1430 drugs, 5880 ADRs and 140 064 drug-ADR pairs, which is an increase of 40{\%} compared to the previous version. For more fine-grained analyses, we extracted the frequency with which side effects occur from the package inserts. This information is available for 39{\%} of drug-ADR pairs, 19{\%} of which can be compared to the frequency under placebo treatment. SIDER furthermore contains a data set of drug indications, extracted from the package inserts using Natural Language Processing. These drug indications are used to reduce the rate of false positives by identifying medical terms that do not correspond to ADRs.",
author = "Michael Kuhn and Ivica Letunic and Jensen, {Lars Juhl} and Peer Bork",
note = "{\circledC} The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.",
year = "2016",
month = "1",
day = "4",
doi = "10.1093/nar/gkv1075",
language = "English",
volume = "44",
pages = "D1075--9",
journal = "Nucleic Acids Research",
issn = "0305-1048",
publisher = "Oxford University Press",

}

RIS

TY - JOUR

T1 - The SIDER database of drugs and side effects

AU - Kuhn, Michael

AU - Letunic, Ivica

AU - Jensen, Lars Juhl

AU - Bork, Peer

N1 - © The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

PY - 2016/1/4

Y1 - 2016/1/4

N2 - Unwanted side effects of drugs are a burden on patients and a severe impediment in the development of new drugs. At the same time, adverse drug reactions (ADRs) recorded during clinical trials are an important source of human phenotypic data. It is therefore essential to combine data on drugs, targets and side effects into a more complete picture of the therapeutic mechanism of actions of drugs and the ways in which they cause adverse reactions. To this end, we have created the SIDER ('Side Effect Resource', http://sideeffects.embl.de) database of drugs and ADRs. The current release, SIDER 4, contains data on 1430 drugs, 5880 ADRs and 140 064 drug-ADR pairs, which is an increase of 40% compared to the previous version. For more fine-grained analyses, we extracted the frequency with which side effects occur from the package inserts. This information is available for 39% of drug-ADR pairs, 19% of which can be compared to the frequency under placebo treatment. SIDER furthermore contains a data set of drug indications, extracted from the package inserts using Natural Language Processing. These drug indications are used to reduce the rate of false positives by identifying medical terms that do not correspond to ADRs.

AB - Unwanted side effects of drugs are a burden on patients and a severe impediment in the development of new drugs. At the same time, adverse drug reactions (ADRs) recorded during clinical trials are an important source of human phenotypic data. It is therefore essential to combine data on drugs, targets and side effects into a more complete picture of the therapeutic mechanism of actions of drugs and the ways in which they cause adverse reactions. To this end, we have created the SIDER ('Side Effect Resource', http://sideeffects.embl.de) database of drugs and ADRs. The current release, SIDER 4, contains data on 1430 drugs, 5880 ADRs and 140 064 drug-ADR pairs, which is an increase of 40% compared to the previous version. For more fine-grained analyses, we extracted the frequency with which side effects occur from the package inserts. This information is available for 39% of drug-ADR pairs, 19% of which can be compared to the frequency under placebo treatment. SIDER furthermore contains a data set of drug indications, extracted from the package inserts using Natural Language Processing. These drug indications are used to reduce the rate of false positives by identifying medical terms that do not correspond to ADRs.

U2 - 10.1093/nar/gkv1075

DO - 10.1093/nar/gkv1075

M3 - Journal article

C2 - 26481350

VL - 44

SP - D1075-9

JO - Nucleic Acids Research

JF - Nucleic Acids Research

SN - 0305-1048

ER -

ID: 153427506