TCRD and Pharos 2021: mining the human proteome for disease biology

Research output: Contribution to journalJournal articlepeer-review

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TCRD and Pharos 2021 : mining the human proteome for disease biology. / Sheils, Timothy K.; Mathias, Stephen L.; Kelleher, Keith J.; Siramshetty, Vishal B.; Nguyen, Dac Trung; Bologa, Cristian G.; Jensen, Lars Juhl; Vidović, Dušica; Koleti, Amar; Schürer, Stephan C.; Waller, Anna; Yang, Jeremy J.; Holmes, Jayme; Bocci, Giovanni; Southall, Noel; Dharkar, Poorva; Mathé, Ewy; Simeonov, Anton; Oprea, Tudor I.

In: Nucleic Acids Research, Vol. 49, No. D1, 2021, p. D1334-D1346.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Sheils, TK, Mathias, SL, Kelleher, KJ, Siramshetty, VB, Nguyen, DT, Bologa, CG, Jensen, LJ, Vidović, D, Koleti, A, Schürer, SC, Waller, A, Yang, JJ, Holmes, J, Bocci, G, Southall, N, Dharkar, P, Mathé, E, Simeonov, A & Oprea, TI 2021, 'TCRD and Pharos 2021: mining the human proteome for disease biology', Nucleic Acids Research, vol. 49, no. D1, pp. D1334-D1346. https://doi.org/10.1093/nar/gkaa993

APA

Sheils, T. K., Mathias, S. L., Kelleher, K. J., Siramshetty, V. B., Nguyen, D. T., Bologa, C. G., Jensen, L. J., Vidović, D., Koleti, A., Schürer, S. C., Waller, A., Yang, J. J., Holmes, J., Bocci, G., Southall, N., Dharkar, P., Mathé, E., Simeonov, A., & Oprea, T. I. (2021). TCRD and Pharos 2021: mining the human proteome for disease biology. Nucleic Acids Research, 49(D1), D1334-D1346. https://doi.org/10.1093/nar/gkaa993

Vancouver

Sheils TK, Mathias SL, Kelleher KJ, Siramshetty VB, Nguyen DT, Bologa CG et al. TCRD and Pharos 2021: mining the human proteome for disease biology. Nucleic Acids Research. 2021;49(D1):D1334-D1346. https://doi.org/10.1093/nar/gkaa993

Author

Sheils, Timothy K. ; Mathias, Stephen L. ; Kelleher, Keith J. ; Siramshetty, Vishal B. ; Nguyen, Dac Trung ; Bologa, Cristian G. ; Jensen, Lars Juhl ; Vidović, Dušica ; Koleti, Amar ; Schürer, Stephan C. ; Waller, Anna ; Yang, Jeremy J. ; Holmes, Jayme ; Bocci, Giovanni ; Southall, Noel ; Dharkar, Poorva ; Mathé, Ewy ; Simeonov, Anton ; Oprea, Tudor I. / TCRD and Pharos 2021 : mining the human proteome for disease biology. In: Nucleic Acids Research. 2021 ; Vol. 49, No. D1. pp. D1334-D1346.

Bibtex

@article{22edd1cfe8e3465b9d09d995897e8c0d,
title = "TCRD and Pharos 2021: mining the human proteome for disease biology",
abstract = "In 2014, the National Institutes of Health (NIH) initiated the Illuminating the Druggable Genome (IDG) program to identify and improve our understanding of poorly characterized proteins that can potentially be modulated using small molecules or biologics. Two resources produced from these efforts are: The Target Central Resource Database (TCRD) (http://juniper.health.unm.edu/tcrd/) and Pharos (https://pharos.nih.gov/), a web interface to browse the TCRD. The ultimate goal of these resources is to highlight and facilitate research into currently understudied proteins, by aggregating a multitude of data sources, and ranking targets based on the amount of data available, and presenting data in machine learning ready format. Since the 2017 release, both TCRD and Pharos have produced two major releases, which have incorporated or expanded an additional 25 data sources. Recently incorporated data types include human and viral-human protein-protein interactions, protein-disease and protein-phenotype associations, and drug-induced gene signatures, among others. These aggregated data have enabled us to generate new visualizations and content sections in Pharos, in order to empower users to find new areas of study in the druggable genome.",
author = "Sheils, {Timothy K.} and Mathias, {Stephen L.} and Kelleher, {Keith J.} and Siramshetty, {Vishal B.} and Nguyen, {Dac Trung} and Bologa, {Cristian G.} and Jensen, {Lars Juhl} and Du{\v s}ica Vidovi{\'c} and Amar Koleti and Sch{\"u}rer, {Stephan C.} and Anna Waller and Yang, {Jeremy J.} and Jayme Holmes and Giovanni Bocci and Noel Southall and Poorva Dharkar and Ewy Math{\'e} and Anton Simeonov and Oprea, {Tudor I.}",
year = "2021",
doi = "10.1093/nar/gkaa993",
language = "English",
volume = "49",
pages = "D1334--D1346",
journal = "Nucleic Acids Research",
issn = "0305-1048",
publisher = "Oxford University Press",
number = "D1",

}

RIS

TY - JOUR

T1 - TCRD and Pharos 2021

T2 - mining the human proteome for disease biology

AU - Sheils, Timothy K.

AU - Mathias, Stephen L.

AU - Kelleher, Keith J.

AU - Siramshetty, Vishal B.

AU - Nguyen, Dac Trung

AU - Bologa, Cristian G.

AU - Jensen, Lars Juhl

AU - Vidović, Dušica

AU - Koleti, Amar

AU - Schürer, Stephan C.

AU - Waller, Anna

AU - Yang, Jeremy J.

AU - Holmes, Jayme

AU - Bocci, Giovanni

AU - Southall, Noel

AU - Dharkar, Poorva

AU - Mathé, Ewy

AU - Simeonov, Anton

AU - Oprea, Tudor I.

PY - 2021

Y1 - 2021

N2 - In 2014, the National Institutes of Health (NIH) initiated the Illuminating the Druggable Genome (IDG) program to identify and improve our understanding of poorly characterized proteins that can potentially be modulated using small molecules or biologics. Two resources produced from these efforts are: The Target Central Resource Database (TCRD) (http://juniper.health.unm.edu/tcrd/) and Pharos (https://pharos.nih.gov/), a web interface to browse the TCRD. The ultimate goal of these resources is to highlight and facilitate research into currently understudied proteins, by aggregating a multitude of data sources, and ranking targets based on the amount of data available, and presenting data in machine learning ready format. Since the 2017 release, both TCRD and Pharos have produced two major releases, which have incorporated or expanded an additional 25 data sources. Recently incorporated data types include human and viral-human protein-protein interactions, protein-disease and protein-phenotype associations, and drug-induced gene signatures, among others. These aggregated data have enabled us to generate new visualizations and content sections in Pharos, in order to empower users to find new areas of study in the druggable genome.

AB - In 2014, the National Institutes of Health (NIH) initiated the Illuminating the Druggable Genome (IDG) program to identify and improve our understanding of poorly characterized proteins that can potentially be modulated using small molecules or biologics. Two resources produced from these efforts are: The Target Central Resource Database (TCRD) (http://juniper.health.unm.edu/tcrd/) and Pharos (https://pharos.nih.gov/), a web interface to browse the TCRD. The ultimate goal of these resources is to highlight and facilitate research into currently understudied proteins, by aggregating a multitude of data sources, and ranking targets based on the amount of data available, and presenting data in machine learning ready format. Since the 2017 release, both TCRD and Pharos have produced two major releases, which have incorporated or expanded an additional 25 data sources. Recently incorporated data types include human and viral-human protein-protein interactions, protein-disease and protein-phenotype associations, and drug-induced gene signatures, among others. These aggregated data have enabled us to generate new visualizations and content sections in Pharos, in order to empower users to find new areas of study in the druggable genome.

U2 - 10.1093/nar/gkaa993

DO - 10.1093/nar/gkaa993

M3 - Journal article

C2 - 33156327

AN - SCOPUS:85099429035

VL - 49

SP - D1334-D1346

JO - Nucleic Acids Research

JF - Nucleic Acids Research

SN - 0305-1048

IS - D1

ER -

ID: 256214282