TCRD and Pharos 2021: mining the human proteome for disease biology
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TCRD and Pharos 2021 : mining the human proteome for disease biology. / Sheils, Timothy K.; Mathias, Stephen L.; Kelleher, Keith J.; Siramshetty, Vishal B.; Nguyen, Dac Trung; Bologa, Cristian G.; Jensen, Lars Juhl; Vidović, Dušica; Koleti, Amar; Schürer, Stephan C.; Waller, Anna; Yang, Jeremy J.; Holmes, Jayme; Bocci, Giovanni; Southall, Noel; Dharkar, Poorva; Mathé, Ewy; Simeonov, Anton; Oprea, Tudor I.
In: Nucleic Acids Research, Vol. 49, No. D1, 2021, p. D1334-D1346.Research output: Contribution to journal › Journal article › peer-review
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TY - JOUR
T1 - TCRD and Pharos 2021
T2 - mining the human proteome for disease biology
AU - Sheils, Timothy K.
AU - Mathias, Stephen L.
AU - Kelleher, Keith J.
AU - Siramshetty, Vishal B.
AU - Nguyen, Dac Trung
AU - Bologa, Cristian G.
AU - Jensen, Lars Juhl
AU - Vidović, Dušica
AU - Koleti, Amar
AU - Schürer, Stephan C.
AU - Waller, Anna
AU - Yang, Jeremy J.
AU - Holmes, Jayme
AU - Bocci, Giovanni
AU - Southall, Noel
AU - Dharkar, Poorva
AU - Mathé, Ewy
AU - Simeonov, Anton
AU - Oprea, Tudor I.
PY - 2021
Y1 - 2021
N2 - In 2014, the National Institutes of Health (NIH) initiated the Illuminating the Druggable Genome (IDG) program to identify and improve our understanding of poorly characterized proteins that can potentially be modulated using small molecules or biologics. Two resources produced from these efforts are: The Target Central Resource Database (TCRD) (http://juniper.health.unm.edu/tcrd/) and Pharos (https://pharos.nih.gov/), a web interface to browse the TCRD. The ultimate goal of these resources is to highlight and facilitate research into currently understudied proteins, by aggregating a multitude of data sources, and ranking targets based on the amount of data available, and presenting data in machine learning ready format. Since the 2017 release, both TCRD and Pharos have produced two major releases, which have incorporated or expanded an additional 25 data sources. Recently incorporated data types include human and viral-human protein-protein interactions, protein-disease and protein-phenotype associations, and drug-induced gene signatures, among others. These aggregated data have enabled us to generate new visualizations and content sections in Pharos, in order to empower users to find new areas of study in the druggable genome.
AB - In 2014, the National Institutes of Health (NIH) initiated the Illuminating the Druggable Genome (IDG) program to identify and improve our understanding of poorly characterized proteins that can potentially be modulated using small molecules or biologics. Two resources produced from these efforts are: The Target Central Resource Database (TCRD) (http://juniper.health.unm.edu/tcrd/) and Pharos (https://pharos.nih.gov/), a web interface to browse the TCRD. The ultimate goal of these resources is to highlight and facilitate research into currently understudied proteins, by aggregating a multitude of data sources, and ranking targets based on the amount of data available, and presenting data in machine learning ready format. Since the 2017 release, both TCRD and Pharos have produced two major releases, which have incorporated or expanded an additional 25 data sources. Recently incorporated data types include human and viral-human protein-protein interactions, protein-disease and protein-phenotype associations, and drug-induced gene signatures, among others. These aggregated data have enabled us to generate new visualizations and content sections in Pharos, in order to empower users to find new areas of study in the druggable genome.
U2 - 10.1093/nar/gkaa993
DO - 10.1093/nar/gkaa993
M3 - Journal article
C2 - 33156327
AN - SCOPUS:85099429035
VL - 49
SP - D1334-D1346
JO - Nucleic Acids Research
JF - Nucleic Acids Research
SN - 0305-1048
IS - D1
ER -
ID: 256214282