RNF138 joins the HR team

Research output: Contribution to journalJournal articlepeer-review

Two studies show that the E3 ubiquitin ligase RNF138 is recruited to DNA double-strand break sites, where it ubiquitylates key repair factors to promote DNA-end resection and homologous recombination. These findings add insights into the multilayered regulatory mechanisms underlying DNA double-strand break repair pathway choice in mammalian cells.

Original languageEnglish
JournalNature Cell Biology
Volume17
Issue number11
Pages (from-to)1375-7
Number of pages3
ISSN1465-7392
DOIs
Publication statusPublished - Oct 2015

ID: 152956640