Recycling of modified H2A-H2B provides short-term memory of chromatin states

Research output: Contribution to journalJournal articlepeer-review

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Recycling of modified H2A-H2B provides short-term memory of chromatin states. / Flury, Valentin; Reverón-Gómez, Nazaret; Alcaraz, Nicolas; Stewart-Morgan, Kathleen R.; Wenger, Alice; Klose, Robert J.; Groth, Anja.

In: Cell, Vol. 186, No. 5, 2023, p. 1050-1065.e19.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Flury, V, Reverón-Gómez, N, Alcaraz, N, Stewart-Morgan, KR, Wenger, A, Klose, RJ & Groth, A 2023, 'Recycling of modified H2A-H2B provides short-term memory of chromatin states', Cell, vol. 186, no. 5, pp. 1050-1065.e19. https://doi.org/10.1016/j.cell.2023.01.007

APA

Flury, V., Reverón-Gómez, N., Alcaraz, N., Stewart-Morgan, K. R., Wenger, A., Klose, R. J., & Groth, A. (2023). Recycling of modified H2A-H2B provides short-term memory of chromatin states. Cell, 186(5), 1050-1065.e19. https://doi.org/10.1016/j.cell.2023.01.007

Vancouver

Flury V, Reverón-Gómez N, Alcaraz N, Stewart-Morgan KR, Wenger A, Klose RJ et al. Recycling of modified H2A-H2B provides short-term memory of chromatin states. Cell. 2023;186(5):1050-1065.e19. https://doi.org/10.1016/j.cell.2023.01.007

Author

Flury, Valentin ; Reverón-Gómez, Nazaret ; Alcaraz, Nicolas ; Stewart-Morgan, Kathleen R. ; Wenger, Alice ; Klose, Robert J. ; Groth, Anja. / Recycling of modified H2A-H2B provides short-term memory of chromatin states. In: Cell. 2023 ; Vol. 186, No. 5. pp. 1050-1065.e19.

Bibtex

@article{f30a03cfd4da4b4a865aa7b75135a729,
title = "Recycling of modified H2A-H2B provides short-term memory of chromatin states",
abstract = "Chromatin landscapes are disrupted during DNA replication and must be restored faithfully to maintain genome regulation and cell identity. The histone H3-H4 modification landscape is restored by parental histone recycling and modification of new histones. How DNA replication impacts on histone H2A-H2B is currently unknown. Here, we measure H2A-H2B modifications and H2A.Z during DNA replication and across the cell cycle using quantitative genomics. We show that H2AK119ub1, H2BK120ub1, and H2A.Z are recycled accurately during DNA replication. Modified H2A-H2B are segregated symmetrically to daughter strands via POLA1 on the lagging strand, but independent of H3-H4 recycling. Post-replication, H2A-H2B modification and variant landscapes are quickly restored, and H2AK119ub1 guides accurate restoration of H3K27me3. This work reveals epigenetic transmission of parental H2A-H2B during DNA replication and identifies cross talk between H3-H4 and H2A-H2B modifications in epigenome propagation. We propose that rapid short-term memory of recycled H2A-H2B modifications facilitates restoration of stable H3-H4 chromatin states.",
author = "Valentin Flury and Nazaret Rever{\'o}n-G{\'o}mez and Nicolas Alcaraz and Stewart-Morgan, {Kathleen R.} and Alice Wenger and Klose, {Robert J.} and Anja Groth",
note = "Copyright {\textcopyright} 2023 The Author(s). Published by Elsevier Inc. All rights reserved.",
year = "2023",
doi = "10.1016/j.cell.2023.01.007",
language = "English",
volume = "186",
pages = "1050--1065.e19",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "5",

}

RIS

TY - JOUR

T1 - Recycling of modified H2A-H2B provides short-term memory of chromatin states

AU - Flury, Valentin

AU - Reverón-Gómez, Nazaret

AU - Alcaraz, Nicolas

AU - Stewart-Morgan, Kathleen R.

AU - Wenger, Alice

AU - Klose, Robert J.

AU - Groth, Anja

N1 - Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.

PY - 2023

Y1 - 2023

N2 - Chromatin landscapes are disrupted during DNA replication and must be restored faithfully to maintain genome regulation and cell identity. The histone H3-H4 modification landscape is restored by parental histone recycling and modification of new histones. How DNA replication impacts on histone H2A-H2B is currently unknown. Here, we measure H2A-H2B modifications and H2A.Z during DNA replication and across the cell cycle using quantitative genomics. We show that H2AK119ub1, H2BK120ub1, and H2A.Z are recycled accurately during DNA replication. Modified H2A-H2B are segregated symmetrically to daughter strands via POLA1 on the lagging strand, but independent of H3-H4 recycling. Post-replication, H2A-H2B modification and variant landscapes are quickly restored, and H2AK119ub1 guides accurate restoration of H3K27me3. This work reveals epigenetic transmission of parental H2A-H2B during DNA replication and identifies cross talk between H3-H4 and H2A-H2B modifications in epigenome propagation. We propose that rapid short-term memory of recycled H2A-H2B modifications facilitates restoration of stable H3-H4 chromatin states.

AB - Chromatin landscapes are disrupted during DNA replication and must be restored faithfully to maintain genome regulation and cell identity. The histone H3-H4 modification landscape is restored by parental histone recycling and modification of new histones. How DNA replication impacts on histone H2A-H2B is currently unknown. Here, we measure H2A-H2B modifications and H2A.Z during DNA replication and across the cell cycle using quantitative genomics. We show that H2AK119ub1, H2BK120ub1, and H2A.Z are recycled accurately during DNA replication. Modified H2A-H2B are segregated symmetrically to daughter strands via POLA1 on the lagging strand, but independent of H3-H4 recycling. Post-replication, H2A-H2B modification and variant landscapes are quickly restored, and H2AK119ub1 guides accurate restoration of H3K27me3. This work reveals epigenetic transmission of parental H2A-H2B during DNA replication and identifies cross talk between H3-H4 and H2A-H2B modifications in epigenome propagation. We propose that rapid short-term memory of recycled H2A-H2B modifications facilitates restoration of stable H3-H4 chromatin states.

U2 - 10.1016/j.cell.2023.01.007

DO - 10.1016/j.cell.2023.01.007

M3 - Journal article

C2 - 36750094

VL - 186

SP - 1050-1065.e19

JO - Cell

JF - Cell

SN - 0092-8674

IS - 5

ER -

ID: 337355397