Protein-Protein Interaction Databases
Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
Years of meticulous curation of scientific literature and increasingly reliable computational predictions have resulted in creation of vast databases of protein interaction data. Over the years, these repositories have become a basic framework in which experiments are analyzed and new directions of research are explored. Here we present an overview of the most widely used protein-protein interaction databases and the methods they employ to gather, combine, and predict interactions. We also point out the trade-off between comprehensiveness and accuracy and the main pitfall scientists have to be aware before adopting protein interaction databases in any single-gene or genome-wide analysis.
Original language | English |
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Title of host publication | Protein-Protein Interactions : Methods and Applications |
Editors | Cheryl L. Meyerkord, Haian Fu |
Number of pages | 18 |
Volume | 1278 |
Place of Publication | New York |
Publisher | Springer Publishing Company |
Publication date | 2015 |
Edition | 2 |
Pages | 39-56 |
Chapter | 3 |
ISBN (Print) | 978-1-4939-2424-0 |
ISBN (Electronic) | 978-1-4939-2425-7 |
DOIs | |
Publication status | Published - 2015 |
Series | Methods in Molecular Biology |
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Volume | 1278 |
ISSN | 1064-3745 |
ID: 141012425