Protein interaction networks from yeast to human
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Protein interaction networks from yeast to human. / Bork, Peer; Jensen, Lars J; von Mering, Christian; Ramani, Arun K; Lee, Insuk; Marcotte, Edward M.
In: Current Opinion in Structural Biology, Vol. 14, No. 3, 2004, p. 292-9.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Protein interaction networks from yeast to human
AU - Bork, Peer
AU - Jensen, Lars J
AU - von Mering, Christian
AU - Ramani, Arun K
AU - Lee, Insuk
AU - Marcotte, Edward M
PY - 2004
Y1 - 2004
N2 - Protein interaction networks summarize large amounts of protein-protein interaction data, both from individual, small-scale experiments and from automated high-throughput screens. The past year has seen a flood of new experimental data, especially on metazoans, as well as an increasing number of analyses designed to reveal aspects of network topology, modularity and evolution. As only minimal progress has been made in mapping the human proteome using high-throughput screens, the transfer of interaction information within and across species has become increasingly important. With more and more heterogeneous raw data becoming available, proper data integration and quality control have become essential for reliable protein network reconstruction, and will be especially important for reconstructing the human protein interaction network.
AB - Protein interaction networks summarize large amounts of protein-protein interaction data, both from individual, small-scale experiments and from automated high-throughput screens. The past year has seen a flood of new experimental data, especially on metazoans, as well as an increasing number of analyses designed to reveal aspects of network topology, modularity and evolution. As only minimal progress has been made in mapping the human proteome using high-throughput screens, the transfer of interaction information within and across species has become increasingly important. With more and more heterogeneous raw data becoming available, proper data integration and quality control have become essential for reliable protein network reconstruction, and will be especially important for reconstructing the human protein interaction network.
U2 - 10.1016/j.sbi.2004.05.003
DO - 10.1016/j.sbi.2004.05.003
M3 - Journal article
C2 - 15193308
VL - 14
SP - 292
EP - 299
JO - Current Opinion in Structural Biology
JF - Current Opinion in Structural Biology
SN - 0959-440X
IS - 3
ER -
ID: 40749541