Origin of replication in circular prokaryotic chromosomes

Research output: Contribution to journalJournal articleResearchpeer-review

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Origin of replication in circular prokaryotic chromosomes. / Worning, Peder; Jensen, Lars J; Hallin, Peter Fischer; Staerfeldt, Hans-Henrik; Ussery, David.

In: Environmental Microbiology, Vol. 8, No. 2, 2006, p. 353-61.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Worning, P, Jensen, LJ, Hallin, PF, Staerfeldt, H-H & Ussery, D 2006, 'Origin of replication in circular prokaryotic chromosomes', Environmental Microbiology, vol. 8, no. 2, pp. 353-61. https://doi.org/10.1111/j.1462-2920.2005.00917.x

APA

Worning, P., Jensen, L. J., Hallin, P. F., Staerfeldt, H-H., & Ussery, D. (2006). Origin of replication in circular prokaryotic chromosomes. Environmental Microbiology, 8(2), 353-61. https://doi.org/10.1111/j.1462-2920.2005.00917.x

Vancouver

Worning P, Jensen LJ, Hallin PF, Staerfeldt H-H, Ussery D. Origin of replication in circular prokaryotic chromosomes. Environmental Microbiology. 2006;8(2):353-61. https://doi.org/10.1111/j.1462-2920.2005.00917.x

Author

Worning, Peder ; Jensen, Lars J ; Hallin, Peter Fischer ; Staerfeldt, Hans-Henrik ; Ussery, David. / Origin of replication in circular prokaryotic chromosomes. In: Environmental Microbiology. 2006 ; Vol. 8, No. 2. pp. 353-61.

Bibtex

@article{55a64d865eb54ad5bb93a90ff928841e,
title = "Origin of replication in circular prokaryotic chromosomes",
abstract = "To predict origins of replication in prokaryotic chromosomes, we analyse the leading and lagging strands of 200 chromosomes for differences in oligomer composition and show that these correlate strongly with taxonomic grouping, lifestyle and molecular details of the replication process. While all bacteria have a preference for Gs over Cs on the leading strand, we discover that the direction of the A/T skew is determined by the polymerase-alpha subunit that replicates the leading strand. The strength of the strand bias varies greatly between both phyla and environments and appears to correlate with growth rate. Finally we observe much greater diversity of skew among archaea than among bacteria. We have developed a program that accurately locates the origins of replication by measuring the differences between leading and lagging strand of all oligonucleotides up to 8 bp in length. The program and results for all publicly available genomes are available from http://www.cbs.dtu.dk/services/GenomeAtlas/suppl/origin.",
author = "Peder Worning and Jensen, {Lars J} and Hallin, {Peter Fischer} and Hans-Henrik Staerfeldt and David Ussery",
year = "2006",
doi = "10.1111/j.1462-2920.2005.00917.x",
language = "English",
volume = "8",
pages = "353--61",
journal = "Environmental Microbiology",
issn = "1462-2912",
publisher = "Wiley-Blackwell",
number = "2",

}

RIS

TY - JOUR

T1 - Origin of replication in circular prokaryotic chromosomes

AU - Worning, Peder

AU - Jensen, Lars J

AU - Hallin, Peter Fischer

AU - Staerfeldt, Hans-Henrik

AU - Ussery, David

PY - 2006

Y1 - 2006

N2 - To predict origins of replication in prokaryotic chromosomes, we analyse the leading and lagging strands of 200 chromosomes for differences in oligomer composition and show that these correlate strongly with taxonomic grouping, lifestyle and molecular details of the replication process. While all bacteria have a preference for Gs over Cs on the leading strand, we discover that the direction of the A/T skew is determined by the polymerase-alpha subunit that replicates the leading strand. The strength of the strand bias varies greatly between both phyla and environments and appears to correlate with growth rate. Finally we observe much greater diversity of skew among archaea than among bacteria. We have developed a program that accurately locates the origins of replication by measuring the differences between leading and lagging strand of all oligonucleotides up to 8 bp in length. The program and results for all publicly available genomes are available from http://www.cbs.dtu.dk/services/GenomeAtlas/suppl/origin.

AB - To predict origins of replication in prokaryotic chromosomes, we analyse the leading and lagging strands of 200 chromosomes for differences in oligomer composition and show that these correlate strongly with taxonomic grouping, lifestyle and molecular details of the replication process. While all bacteria have a preference for Gs over Cs on the leading strand, we discover that the direction of the A/T skew is determined by the polymerase-alpha subunit that replicates the leading strand. The strength of the strand bias varies greatly between both phyla and environments and appears to correlate with growth rate. Finally we observe much greater diversity of skew among archaea than among bacteria. We have developed a program that accurately locates the origins of replication by measuring the differences between leading and lagging strand of all oligonucleotides up to 8 bp in length. The program and results for all publicly available genomes are available from http://www.cbs.dtu.dk/services/GenomeAtlas/suppl/origin.

U2 - 10.1111/j.1462-2920.2005.00917.x

DO - 10.1111/j.1462-2920.2005.00917.x

M3 - Journal article

C2 - 16423021

VL - 8

SP - 353

EP - 361

JO - Environmental Microbiology

JF - Environmental Microbiology

SN - 1462-2912

IS - 2

ER -

ID: 40749297