MCM2 promotes symmetric inheritance of modified histones during DNA replication

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

MCM2 promotes symmetric inheritance of modified histones during DNA replication. / Petryk, Nataliya; Dalby, Maria; Wenger, Alice; Stromme, Caroline B.; Strandsby, Anne; Andersson, Robin; Groth, Anja.

In: Science, Vol. 361, No. 6409, 2018, p. 1389-1392.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Petryk, N, Dalby, M, Wenger, A, Stromme, CB, Strandsby, A, Andersson, R & Groth, A 2018, 'MCM2 promotes symmetric inheritance of modified histones during DNA replication', Science, vol. 361, no. 6409, pp. 1389-1392. https://doi.org/10.1126/science.aau0294

APA

Petryk, N., Dalby, M., Wenger, A., Stromme, C. B., Strandsby, A., Andersson, R., & Groth, A. (2018). MCM2 promotes symmetric inheritance of modified histones during DNA replication. Science, 361(6409), 1389-1392. https://doi.org/10.1126/science.aau0294

Vancouver

Petryk N, Dalby M, Wenger A, Stromme CB, Strandsby A, Andersson R et al. MCM2 promotes symmetric inheritance of modified histones during DNA replication. Science. 2018;361(6409):1389-1392. https://doi.org/10.1126/science.aau0294

Author

Petryk, Nataliya ; Dalby, Maria ; Wenger, Alice ; Stromme, Caroline B. ; Strandsby, Anne ; Andersson, Robin ; Groth, Anja. / MCM2 promotes symmetric inheritance of modified histones during DNA replication. In: Science. 2018 ; Vol. 361, No. 6409. pp. 1389-1392.

Bibtex

@article{547360713f67488d985fee6544e5d9d7,
title = "MCM2 promotes symmetric inheritance of modified histones during DNA replication",
abstract = "During genome replication, parental histones are recycled to newly replicated DNA with their posttranslational modifications (PTMs). It remains unknown whether sister chromatids inherit modified histones evenly. Here, we measured histone PTM partition to sister chromatids in embryonic stem cells. We found that parental histones H3-H4 segregate to both daughter DNA strands with a weak leading strand bias, skewing partition at topologically associating domain (TAD) borders and enhancers proximal to replication initiation zones. Segregation of parental histones to the leading strand increased markedly in cells with histone-binding mutations in MCM2, part of the replicative helicase, exacerbating histone PTM sister chromatid asymmetry. This work reveals how histones are inherited to sister chromatids and identifies a mechanism for how symmetric cell division is ensured by the replication machinery.",
author = "Nataliya Petryk and Maria Dalby and Alice Wenger and Stromme, {Caroline B.} and Anne Strandsby and Robin Andersson and Anja Groth",
note = "Copyright {\textcopyright} 2018, American Association for the Advancement of Science.",
year = "2018",
doi = "10.1126/science.aau0294",
language = "English",
volume = "361",
pages = "1389--1392",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "6409",

}

RIS

TY - JOUR

T1 - MCM2 promotes symmetric inheritance of modified histones during DNA replication

AU - Petryk, Nataliya

AU - Dalby, Maria

AU - Wenger, Alice

AU - Stromme, Caroline B.

AU - Strandsby, Anne

AU - Andersson, Robin

AU - Groth, Anja

N1 - Copyright © 2018, American Association for the Advancement of Science.

PY - 2018

Y1 - 2018

N2 - During genome replication, parental histones are recycled to newly replicated DNA with their posttranslational modifications (PTMs). It remains unknown whether sister chromatids inherit modified histones evenly. Here, we measured histone PTM partition to sister chromatids in embryonic stem cells. We found that parental histones H3-H4 segregate to both daughter DNA strands with a weak leading strand bias, skewing partition at topologically associating domain (TAD) borders and enhancers proximal to replication initiation zones. Segregation of parental histones to the leading strand increased markedly in cells with histone-binding mutations in MCM2, part of the replicative helicase, exacerbating histone PTM sister chromatid asymmetry. This work reveals how histones are inherited to sister chromatids and identifies a mechanism for how symmetric cell division is ensured by the replication machinery.

AB - During genome replication, parental histones are recycled to newly replicated DNA with their posttranslational modifications (PTMs). It remains unknown whether sister chromatids inherit modified histones evenly. Here, we measured histone PTM partition to sister chromatids in embryonic stem cells. We found that parental histones H3-H4 segregate to both daughter DNA strands with a weak leading strand bias, skewing partition at topologically associating domain (TAD) borders and enhancers proximal to replication initiation zones. Segregation of parental histones to the leading strand increased markedly in cells with histone-binding mutations in MCM2, part of the replicative helicase, exacerbating histone PTM sister chromatid asymmetry. This work reveals how histones are inherited to sister chromatids and identifies a mechanism for how symmetric cell division is ensured by the replication machinery.

U2 - 10.1126/science.aau0294

DO - 10.1126/science.aau0294

M3 - Journal article

C2 - 30115746

VL - 361

SP - 1389

EP - 1392

JO - Science

JF - Science

SN - 0036-8075

IS - 6409

ER -

ID: 201187657