Large-scale study of Toxoplasma and Cytomegalovirus shows an association between infection and serious psychiatric disorders
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Large-scale study of Toxoplasma and Cytomegalovirus shows an association between infection and serious psychiatric disorders. / Burgdorf, Kristoffer Sølvsten; Trabjerg, Betina; Giørtz Pedersen, Marianne; Nissen, Janna; Banasik, Karina; Birger Pedersen, Ole; Sørensen, Erik; René Nielsen, Kaspar; Hørup Larsen, Margit; Erikstrup, Christian; Bruun-Rasmussen, Peter; Westergaard, David; Wegner Thørner, Lise; Hjalgrim, Henrik; Martina Paarup, Helene; Brunak, Søren; Pedersen, Carsten B.; Fuller Torrey, E; Werge, Thomas; Bo Mortensen, Preben; Yolken, Robert; Ullum, Henrik.
In: Brain, Behavior, and Immunity, Vol. 79, 2019, p. 152-158.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - Large-scale study of Toxoplasma and Cytomegalovirus shows an association between infection and serious psychiatric disorders
AU - Burgdorf, Kristoffer Sølvsten
AU - Trabjerg, Betina
AU - Giørtz Pedersen, Marianne
AU - Nissen, Janna
AU - Banasik, Karina
AU - Birger Pedersen, Ole
AU - Sørensen, Erik
AU - René Nielsen, Kaspar
AU - Hørup Larsen, Margit
AU - Erikstrup, Christian
AU - Bruun-Rasmussen, Peter
AU - Westergaard, David
AU - Wegner Thørner, Lise
AU - Hjalgrim, Henrik
AU - Martina Paarup, Helene
AU - Brunak, Søren
AU - Pedersen, Carsten B.
AU - Fuller Torrey, E
AU - Werge, Thomas
AU - Bo Mortensen, Preben
AU - Yolken, Robert
AU - Ullum, Henrik
PY - 2019
Y1 - 2019
N2 - BACKGROUND: Common infectious pathogens have been associated with psychiatric disorders, self-violence and risk-taking behavior.METHODS: This case-control study reviews register data on 81,912 individuals from the Danish Blood Donor Study to identify individuals who have a psychiatric diagnosis (N=2,591), have attempted or committed suicide (N=655), or have had traffic accidents (N=2,724). For all cases, controls were frequency matched by age and sex, resulting in 11,546 participants. Plasma samples were analyzed for immunoglobulin G (IgG) antibodies against Toxoplasma gondii and cytomegalovirus (CMV).RESULTS: T. gondii was detected in 25·9% of the population and was associated with schizophrenia (odds ratio [OR], 1·47; 95% confidence interval [CI], 1·03-2·09). Accounting for temporality, with pathogen exposure preceding outcome, the association was even stronger (IRR, 2·78; 95% CI, 1·27-6·09). A very weak association between traffic accident and toxoplasmosis (OR, 1·11; 95% CI, 1·00-1·23, p = 0.054) was found. CMV was detected in 60·8% of the studied population and was associated with any psychiatric disorder (OR, 1·17; 95% CI, 1·06-1·29), but also with a smaller group of neurotic, stress-related, and somatoform disorders (OR, 1·27; 95% CI, 1·12-1·44), and with attempting or committing suicide (OR, 1·31; 95% CI, 1·10-1·56). Accounting for temporality, any psychiatric disorder (IRR, 1·37; 95% CI, 1·08-1·74) and mood disorders (IRR, 1·43; 95% CI, 1·01-2·04) were associated with exposure to CMV. No association between traffic accident and CMV (OR, 1·06; 95% CI, 0·97-1·17) was found.CONCLUSIONS: This large-scale serological study is the first study to examine temporality of pathogen exposure and to provide evidence of a causal relationship between T. gondii and schizophrenia, and between CMV and any psychiatric disorder.
AB - BACKGROUND: Common infectious pathogens have been associated with psychiatric disorders, self-violence and risk-taking behavior.METHODS: This case-control study reviews register data on 81,912 individuals from the Danish Blood Donor Study to identify individuals who have a psychiatric diagnosis (N=2,591), have attempted or committed suicide (N=655), or have had traffic accidents (N=2,724). For all cases, controls were frequency matched by age and sex, resulting in 11,546 participants. Plasma samples were analyzed for immunoglobulin G (IgG) antibodies against Toxoplasma gondii and cytomegalovirus (CMV).RESULTS: T. gondii was detected in 25·9% of the population and was associated with schizophrenia (odds ratio [OR], 1·47; 95% confidence interval [CI], 1·03-2·09). Accounting for temporality, with pathogen exposure preceding outcome, the association was even stronger (IRR, 2·78; 95% CI, 1·27-6·09). A very weak association between traffic accident and toxoplasmosis (OR, 1·11; 95% CI, 1·00-1·23, p = 0.054) was found. CMV was detected in 60·8% of the studied population and was associated with any psychiatric disorder (OR, 1·17; 95% CI, 1·06-1·29), but also with a smaller group of neurotic, stress-related, and somatoform disorders (OR, 1·27; 95% CI, 1·12-1·44), and with attempting or committing suicide (OR, 1·31; 95% CI, 1·10-1·56). Accounting for temporality, any psychiatric disorder (IRR, 1·37; 95% CI, 1·08-1·74) and mood disorders (IRR, 1·43; 95% CI, 1·01-2·04) were associated with exposure to CMV. No association between traffic accident and CMV (OR, 1·06; 95% CI, 0·97-1·17) was found.CONCLUSIONS: This large-scale serological study is the first study to examine temporality of pathogen exposure and to provide evidence of a causal relationship between T. gondii and schizophrenia, and between CMV and any psychiatric disorder.
U2 - 10.1016/j.bbi.2019.01.026
DO - 10.1016/j.bbi.2019.01.026
M3 - Journal article
C2 - 30685531
VL - 79
SP - 152
EP - 158
JO - Brain, Behavior, and Immunity
JF - Brain, Behavior, and Immunity
SN - 0889-1591
ER -
ID: 212505945