Incorporating symptom data in longitudinal disease trajectories for more detailed patient stratification
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Incorporating symptom data in longitudinal disease trajectories for more detailed patient stratification. / Lademann, Martin; Lademann, Mette; Boeck Jensen, Anders; Brunak, Søren.
In: International Journal of Medical Informatics, Vol. 129, 2019, p. 107-113.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Incorporating symptom data in longitudinal disease trajectories for more detailed patient stratification
AU - Lademann, Martin
AU - Lademann, Mette
AU - Boeck Jensen, Anders
AU - Brunak, Søren
PY - 2019
Y1 - 2019
N2 - OBJECTIVE: Use symptoms to stratify temporal disease trajectories.MATERIALS AND METHODS: We use data from the Danish National Patient Registry to stratify temporal disease pairs by the symptom distributions they associate to. The underlying data comprise of 6.6 million patients collectively assigned with 7.5 million symptoms from chapter XVIII in the WHO International Classification of Disease version 10 terminology.RESULTS: We stratify 33 disease pairs into 67 temporal disease-symptom-disease trajectories from three main diagnoses (two diabetes subtypes and COPD), where the symptom significantly changes the risk of developing the subsequent diseases. We combine these trajectories into three temporal disease networks, one for each main diagnosis. We confirm apparent relations between diseases and symptoms and discovered that multiple symptoms decrease the risk for diabetes progression.CONCLUSION: Symptoms can be used to stratify disease trajectories, and we suggest that this approach can be applied to temporal disease trajectories systematically using structured claims data. The method can be extended to also use text-mined symptoms from unstructured data in health records.
AB - OBJECTIVE: Use symptoms to stratify temporal disease trajectories.MATERIALS AND METHODS: We use data from the Danish National Patient Registry to stratify temporal disease pairs by the symptom distributions they associate to. The underlying data comprise of 6.6 million patients collectively assigned with 7.5 million symptoms from chapter XVIII in the WHO International Classification of Disease version 10 terminology.RESULTS: We stratify 33 disease pairs into 67 temporal disease-symptom-disease trajectories from three main diagnoses (two diabetes subtypes and COPD), where the symptom significantly changes the risk of developing the subsequent diseases. We combine these trajectories into three temporal disease networks, one for each main diagnosis. We confirm apparent relations between diseases and symptoms and discovered that multiple symptoms decrease the risk for diabetes progression.CONCLUSION: Symptoms can be used to stratify disease trajectories, and we suggest that this approach can be applied to temporal disease trajectories systematically using structured claims data. The method can be extended to also use text-mined symptoms from unstructured data in health records.
U2 - 10.1016/j.ijmedinf.2019.06.003
DO - 10.1016/j.ijmedinf.2019.06.003
M3 - Journal article
C2 - 31445244
VL - 129
SP - 107
EP - 113
JO - International Journal of Medical Informatics
JF - International Journal of Medical Informatics
SN - 1386-5056
ER -
ID: 227086800