Glucagon-like peptide-1 receptor signaling in acinar cells causes growth dependent release of pancreatic enzymes

Research output: Contribution to journalJournal articlepeer-review

Standard

Glucagon-like peptide-1 receptor signaling in acinar cells causes growth dependent release of pancreatic enzymes. / Albrechtsen, Nicolai Jacob Wewer; Albrechtsen, Reidar; Bremholm, l; Svendsen, Berit; Kuhre, Rune Ehrenreich; Poulsen, Steen Seier; Christiansen, Charlotte Bayer; Jensen, Elisa Pouline; Janus, Charlotte; Hilsted, Linda; Deacon, Carolyn F.; Hartmann, Bolette; Holst, Jens Juul.

In: Cell Reports, Vol. 17, No. 11, 2016, p. 2845-2856.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Albrechtsen, NJW, Albrechtsen, R, Bremholm, L, Svendsen, B, Kuhre, RE, Poulsen, SS, Christiansen, CB, Jensen, EP, Janus, C, Hilsted, L, Deacon, CF, Hartmann, B & Holst, JJ 2016, 'Glucagon-like peptide-1 receptor signaling in acinar cells causes growth dependent release of pancreatic enzymes', Cell Reports, vol. 17, no. 11, pp. 2845-2856. https://doi.org/10.1016/j.celrep.2016.11.051

APA

Albrechtsen, N. J. W., Albrechtsen, R., Bremholm, L., Svendsen, B., Kuhre, R. E., Poulsen, S. S., Christiansen, C. B., Jensen, E. P., Janus, C., Hilsted, L., Deacon, C. F., Hartmann, B., & Holst, J. J. (2016). Glucagon-like peptide-1 receptor signaling in acinar cells causes growth dependent release of pancreatic enzymes. Cell Reports, 17(11), 2845-2856. https://doi.org/10.1016/j.celrep.2016.11.051

Vancouver

Albrechtsen NJW, Albrechtsen R, Bremholm L, Svendsen B, Kuhre RE, Poulsen SS et al. Glucagon-like peptide-1 receptor signaling in acinar cells causes growth dependent release of pancreatic enzymes. Cell Reports. 2016;17(11):2845-2856. https://doi.org/10.1016/j.celrep.2016.11.051

Author

Albrechtsen, Nicolai Jacob Wewer ; Albrechtsen, Reidar ; Bremholm, l ; Svendsen, Berit ; Kuhre, Rune Ehrenreich ; Poulsen, Steen Seier ; Christiansen, Charlotte Bayer ; Jensen, Elisa Pouline ; Janus, Charlotte ; Hilsted, Linda ; Deacon, Carolyn F. ; Hartmann, Bolette ; Holst, Jens Juul. / Glucagon-like peptide-1 receptor signaling in acinar cells causes growth dependent release of pancreatic enzymes. In: Cell Reports. 2016 ; Vol. 17, No. 11. pp. 2845-2856.

Bibtex

@article{30ea7f74bc134f7a90d42707c7717512,
title = "Glucagon-like peptide-1 receptor signaling in acinar cells causes growth dependent release of pancreatic enzymes",
abstract = "Incretin-based therapies are widely used for type 2 diabetes and now also for obesity, but they are associated with elevated plasma levels of pancreatic enzymes and perhaps a modestly increased risk of acute pancreatitis. However, little is known about the effects of the incretin hormone glucagon-like peptide 1 (GLP-1) on the exocrine pancreas. Here, we identify GLP-1 receptors on pancreatic acini and analyze the impact of receptor activation in humans, rodents, isolated acini, and cell lines from the exocrine pancreas. GLP-1 did not directly stimulate amylase or lipase release. However, we saw that GLP-1 induces phosphorylation of the epidermal growth factor receptor and activation of Foxo1, resulting in cell growth with concomitant enzyme release. Our work uncovers GLP-1-induced signaling pathways in the exocrine pancreas and suggests that increases in amylase and lipase levels in subjects treated with GLP-1 receptor agonists reflect adaptive growth rather than early-stage pancreatitis.",
author = "Albrechtsen, {Nicolai Jacob Wewer} and Reidar Albrechtsen and l Bremholm and Berit Svendsen and Kuhre, {Rune Ehrenreich} and Poulsen, {Steen Seier} and Christiansen, {Charlotte Bayer} and Jensen, {Elisa Pouline} and Charlotte Janus and Linda Hilsted and Deacon, {Carolyn F.} and Bolette Hartmann and Holst, {Jens Juul}",
year = "2016",
doi = "10.1016/j.celrep.2016.11.051",
language = "English",
volume = "17",
pages = "2845--2856",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "11",

}

RIS

TY - JOUR

T1 - Glucagon-like peptide-1 receptor signaling in acinar cells causes growth dependent release of pancreatic enzymes

AU - Albrechtsen, Nicolai Jacob Wewer

AU - Albrechtsen, Reidar

AU - Bremholm, l

AU - Svendsen, Berit

AU - Kuhre, Rune Ehrenreich

AU - Poulsen, Steen Seier

AU - Christiansen, Charlotte Bayer

AU - Jensen, Elisa Pouline

AU - Janus, Charlotte

AU - Hilsted, Linda

AU - Deacon, Carolyn F.

AU - Hartmann, Bolette

AU - Holst, Jens Juul

PY - 2016

Y1 - 2016

N2 - Incretin-based therapies are widely used for type 2 diabetes and now also for obesity, but they are associated with elevated plasma levels of pancreatic enzymes and perhaps a modestly increased risk of acute pancreatitis. However, little is known about the effects of the incretin hormone glucagon-like peptide 1 (GLP-1) on the exocrine pancreas. Here, we identify GLP-1 receptors on pancreatic acini and analyze the impact of receptor activation in humans, rodents, isolated acini, and cell lines from the exocrine pancreas. GLP-1 did not directly stimulate amylase or lipase release. However, we saw that GLP-1 induces phosphorylation of the epidermal growth factor receptor and activation of Foxo1, resulting in cell growth with concomitant enzyme release. Our work uncovers GLP-1-induced signaling pathways in the exocrine pancreas and suggests that increases in amylase and lipase levels in subjects treated with GLP-1 receptor agonists reflect adaptive growth rather than early-stage pancreatitis.

AB - Incretin-based therapies are widely used for type 2 diabetes and now also for obesity, but they are associated with elevated plasma levels of pancreatic enzymes and perhaps a modestly increased risk of acute pancreatitis. However, little is known about the effects of the incretin hormone glucagon-like peptide 1 (GLP-1) on the exocrine pancreas. Here, we identify GLP-1 receptors on pancreatic acini and analyze the impact of receptor activation in humans, rodents, isolated acini, and cell lines from the exocrine pancreas. GLP-1 did not directly stimulate amylase or lipase release. However, we saw that GLP-1 induces phosphorylation of the epidermal growth factor receptor and activation of Foxo1, resulting in cell growth with concomitant enzyme release. Our work uncovers GLP-1-induced signaling pathways in the exocrine pancreas and suggests that increases in amylase and lipase levels in subjects treated with GLP-1 receptor agonists reflect adaptive growth rather than early-stage pancreatitis.

U2 - 10.1016/j.celrep.2016.11.051

DO - 10.1016/j.celrep.2016.11.051

M3 - Journal article

C2 - 27974199

VL - 17

SP - 2845

EP - 2856

JO - Cell Reports

JF - Cell Reports

SN - 2211-1247

IS - 11

ER -

ID: 169969826