Establishment and functions of DNA methylation in the germline

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Establishment and functions of DNA methylation in the germline. / Stewart-Morgan, Kathleen; Veselovska, Lenka; Kelsey, Gavin.

In: Epigenomics, Vol. 8, No. 10, 2016, p. 1399-1413.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Stewart-Morgan, K, Veselovska, L & Kelsey, G 2016, 'Establishment and functions of DNA methylation in the germline', Epigenomics, vol. 8, no. 10, pp. 1399-1413. https://doi.org/10.2217/epi-2016-0056

APA

Stewart-Morgan, K., Veselovska, L., & Kelsey, G. (2016). Establishment and functions of DNA methylation in the germline. Epigenomics, 8(10), 1399-1413. https://doi.org/10.2217/epi-2016-0056

Vancouver

Stewart-Morgan K, Veselovska L, Kelsey G. Establishment and functions of DNA methylation in the germline. Epigenomics. 2016;8(10):1399-1413. https://doi.org/10.2217/epi-2016-0056

Author

Stewart-Morgan, Kathleen ; Veselovska, Lenka ; Kelsey, Gavin. / Establishment and functions of DNA methylation in the germline. In: Epigenomics. 2016 ; Vol. 8, No. 10. pp. 1399-1413.

Bibtex

@article{6b471aa118fc49c398572eedba2e8f87,
title = "Establishment and functions of DNA methylation in the germline",
abstract = "Epigenetic modifications established during gametogenesis regulate transcription and other nuclear processes in gametes, but also have influences in the zygote, embryo and postnatal life. This is best understood for DNA methylation which, established at discrete regions of the oocyte and sperm genomes, governs genomic imprinting. In this review, we describe how imprinting has informed our understanding of de novo DNA methylation mechanisms, highlight how recent genome-wide profiling studies have provided unprecedented insights into establishment of the sperm and oocyte methylomes and consider the fate and function of gametic methylation and other epigenetic modifications after fertilization.",
keywords = "DNA methylation, embryo, imprinting, oogenesis, spermatogenesis, transgenerational inheritance",
author = "Kathleen Stewart-Morgan and Lenka Veselovska and Gavin Kelsey",
year = "2016",
doi = "10.2217/epi-2016-0056",
language = "English",
volume = "8",
pages = "1399--1413",
journal = "Epigenomics",
issn = "1750-1911",
publisher = "Future Medicine Ltd.",
number = "10",

}

RIS

TY - JOUR

T1 - Establishment and functions of DNA methylation in the germline

AU - Stewart-Morgan, Kathleen

AU - Veselovska, Lenka

AU - Kelsey, Gavin

PY - 2016

Y1 - 2016

N2 - Epigenetic modifications established during gametogenesis regulate transcription and other nuclear processes in gametes, but also have influences in the zygote, embryo and postnatal life. This is best understood for DNA methylation which, established at discrete regions of the oocyte and sperm genomes, governs genomic imprinting. In this review, we describe how imprinting has informed our understanding of de novo DNA methylation mechanisms, highlight how recent genome-wide profiling studies have provided unprecedented insights into establishment of the sperm and oocyte methylomes and consider the fate and function of gametic methylation and other epigenetic modifications after fertilization.

AB - Epigenetic modifications established during gametogenesis regulate transcription and other nuclear processes in gametes, but also have influences in the zygote, embryo and postnatal life. This is best understood for DNA methylation which, established at discrete regions of the oocyte and sperm genomes, governs genomic imprinting. In this review, we describe how imprinting has informed our understanding of de novo DNA methylation mechanisms, highlight how recent genome-wide profiling studies have provided unprecedented insights into establishment of the sperm and oocyte methylomes and consider the fate and function of gametic methylation and other epigenetic modifications after fertilization.

KW - DNA methylation

KW - embryo

KW - imprinting

KW - oogenesis

KW - spermatogenesis

KW - transgenerational inheritance

U2 - 10.2217/epi-2016-0056

DO - 10.2217/epi-2016-0056

M3 - Review

C2 - 27659720

AN - SCOPUS:84990821386

VL - 8

SP - 1399

EP - 1413

JO - Epigenomics

JF - Epigenomics

SN - 1750-1911

IS - 10

ER -

ID: 179132271