DistiLD Database: diseases and traits in linkage disequilibrium blocks
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DistiLD Database : diseases and traits in linkage disequilibrium blocks. / Palleja, Albert; Horn, Heiko; Eliasson, Sabrina; Jensen, Lars Juhl.
In: Nucleic Acids Research, Vol. 40, No. Database issue, 2012, p. D1036-40.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - DistiLD Database
T2 - diseases and traits in linkage disequilibrium blocks
AU - Palleja, Albert
AU - Horn, Heiko
AU - Eliasson, Sabrina
AU - Jensen, Lars Juhl
PY - 2012
Y1 - 2012
N2 - Genome-wide association studies (GWAS) have identified thousands of single nucleotide polymorphisms (SNPs) associated with the risk of hundreds of diseases. However, there is currently no database that enables non-specialists to answer the following simple questions: which SNPs associated with diseases are in linkage disequilibrium (LD) with a gene of interest? Which chromosomal regions have been associated with a given disease, and which are the potentially causal genes in each region? To answer these questions, we use data from the HapMap Project to partition each chromosome into so-called LD blocks, so that SNPs in LD with each other are preferentially in the same block, whereas SNPs not in LD are in different blocks. By projecting SNPs and genes onto LD blocks, the DistiLD database aims to increase usage of existing GWAS results by making it easy to query and visualize disease-associated SNPs and genes in their chromosomal context. The database is available at http://distild.jensenlab.org/.
AB - Genome-wide association studies (GWAS) have identified thousands of single nucleotide polymorphisms (SNPs) associated with the risk of hundreds of diseases. However, there is currently no database that enables non-specialists to answer the following simple questions: which SNPs associated with diseases are in linkage disequilibrium (LD) with a gene of interest? Which chromosomal regions have been associated with a given disease, and which are the potentially causal genes in each region? To answer these questions, we use data from the HapMap Project to partition each chromosome into so-called LD blocks, so that SNPs in LD with each other are preferentially in the same block, whereas SNPs not in LD are in different blocks. By projecting SNPs and genes onto LD blocks, the DistiLD database aims to increase usage of existing GWAS results by making it easy to query and visualize disease-associated SNPs and genes in their chromosomal context. The database is available at http://distild.jensenlab.org/.
KW - Databases, Nucleic Acid
KW - Disease
KW - Genome-Wide Association Study
KW - Linkage Disequilibrium
KW - Molecular Sequence Annotation
KW - Polymorphism, Single Nucleotide
KW - User-Computer Interface
U2 - 10.1093/nar/gkr899
DO - 10.1093/nar/gkr899
M3 - Journal article
C2 - 22058129
VL - 40
SP - D1036-40
JO - Nucleic Acids Research
JF - Nucleic Acids Research
SN - 0305-1048
IS - Database issue
ER -
ID: 40289905