Comprehensive comparison of large-scale tissue expression datasets

Research output: Contribution to journalJournal articleResearchpeer-review

For tissues to carry out their functions, they rely on the right proteins to be present. Several high-throughput technologies have been used to map out which proteins are expressed in which tissues; however, the data have not previously been systematically compared and integrated. We present a comprehensive evaluation of tissue expression data from a variety of experimental techniques and show that these agree surprisingly well with each other and with results from literature curation and text mining. We further found that most datasets support the assumed but not demonstrated distinction between tissue-specific and ubiquitous expression. By developing comparable confidence scores for all types of evidence, we show that it is possible to improve both quality and coverage by combining the datasets. To facilitate use and visualization of our work, we have developed the TISSUES resource (http://tissues.jensenlab.org), which makes all the scored and integrated data available through a single user-friendly web interface.

Original languageEnglish
JournalPeerJ
Volume3
Pages (from-to)e1054
ISSN2167-8359
DOIs
Publication statusPublished - 2015

    Research areas

  • Journal Article

ID: 177047357