Chromatin replication and epigenome maintenance

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Chromatin replication and epigenome maintenance. / Alabert, Constance; Groth, Anja.

In: Nature Reviews. Molecular Cell Biology, Vol. 13, No. 3, 03.2012, p. 153-67.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Alabert, C & Groth, A 2012, 'Chromatin replication and epigenome maintenance', Nature Reviews. Molecular Cell Biology, vol. 13, no. 3, pp. 153-67. https://doi.org/10.1038/nrm3288

APA

Alabert, C., & Groth, A. (2012). Chromatin replication and epigenome maintenance. Nature Reviews. Molecular Cell Biology, 13(3), 153-67. https://doi.org/10.1038/nrm3288

Vancouver

Alabert C, Groth A. Chromatin replication and epigenome maintenance. Nature Reviews. Molecular Cell Biology. 2012 Mar;13(3):153-67. https://doi.org/10.1038/nrm3288

Author

Alabert, Constance ; Groth, Anja. / Chromatin replication and epigenome maintenance. In: Nature Reviews. Molecular Cell Biology. 2012 ; Vol. 13, No. 3. pp. 153-67.

Bibtex

@article{c1fc7a36054747339357dff8e047496e,
title = "Chromatin replication and epigenome maintenance",
abstract = "Stability and function of eukaryotic genomes are closely linked to chromatin structure and organization. During cell division the entire genome must be accurately replicated and the chromatin landscape reproduced on new DNA. Chromatin and nuclear structure influence where and when DNA replication initiates, whereas the replication process itself disrupts chromatin and challenges established patterns of genome regulation. Specialized replication-coupled mechanisms assemble new DNA into chromatin, but epigenome maintenance is a continuous process taking place throughout the cell cycle. If DNA synthesis is perturbed, cells can suffer loss of both genome and epigenome integrity with severe consequences for the organism.",
keywords = "Animals, Cell Division, Chromatin, Chromatin Assembly and Disassembly, DNA Replication, Epigenesis, Genetic, Epigenomics, Genomic Instability, Histones, Humans, Multiprotein Complexes, Replication Origin",
author = "Constance Alabert and Anja Groth",
year = "2012",
month = mar,
doi = "10.1038/nrm3288",
language = "English",
volume = "13",
pages = "153--67",
journal = "Nature Reviews. Molecular Cell Biology",
issn = "1471-0072",
publisher = "nature publishing group",
number = "3",

}

RIS

TY - JOUR

T1 - Chromatin replication and epigenome maintenance

AU - Alabert, Constance

AU - Groth, Anja

PY - 2012/3

Y1 - 2012/3

N2 - Stability and function of eukaryotic genomes are closely linked to chromatin structure and organization. During cell division the entire genome must be accurately replicated and the chromatin landscape reproduced on new DNA. Chromatin and nuclear structure influence where and when DNA replication initiates, whereas the replication process itself disrupts chromatin and challenges established patterns of genome regulation. Specialized replication-coupled mechanisms assemble new DNA into chromatin, but epigenome maintenance is a continuous process taking place throughout the cell cycle. If DNA synthesis is perturbed, cells can suffer loss of both genome and epigenome integrity with severe consequences for the organism.

AB - Stability and function of eukaryotic genomes are closely linked to chromatin structure and organization. During cell division the entire genome must be accurately replicated and the chromatin landscape reproduced on new DNA. Chromatin and nuclear structure influence where and when DNA replication initiates, whereas the replication process itself disrupts chromatin and challenges established patterns of genome regulation. Specialized replication-coupled mechanisms assemble new DNA into chromatin, but epigenome maintenance is a continuous process taking place throughout the cell cycle. If DNA synthesis is perturbed, cells can suffer loss of both genome and epigenome integrity with severe consequences for the organism.

KW - Animals

KW - Cell Division

KW - Chromatin

KW - Chromatin Assembly and Disassembly

KW - DNA Replication

KW - Epigenesis, Genetic

KW - Epigenomics

KW - Genomic Instability

KW - Histones

KW - Humans

KW - Multiprotein Complexes

KW - Replication Origin

U2 - 10.1038/nrm3288

DO - 10.1038/nrm3288

M3 - Review

C2 - 22358331

VL - 13

SP - 153

EP - 167

JO - Nature Reviews. Molecular Cell Biology

JF - Nature Reviews. Molecular Cell Biology

SN - 1471-0072

IS - 3

ER -

ID: 94409533