Chromatin replication and epigenetic cell memory
Research output: Contribution to journal › Review › Research › peer-review
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Chromatin replication and epigenetic cell memory. / Stewart-Morgan, Kathleen R; Petryk, Nataliya; Groth, Anja.
In: Nature Cell Biology, Vol. 22, 2020, p. 361-371.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Chromatin replication and epigenetic cell memory
AU - Stewart-Morgan, Kathleen R
AU - Petryk, Nataliya
AU - Groth, Anja
PY - 2020
Y1 - 2020
N2 - Propagation of the chromatin landscape across cell divisions is central to epigenetic cell memory. Mechanistic analysis of the interplay between DNA replication, the cell cycle, and the epigenome has provided insights into replication-coupled chromatin assembly and post-replicative chromatin maintenance. These breakthroughs are critical for defining how proliferation impacts the epigenome during cell identity changes in development and disease. Here we review these findings in the broader context of epigenetic inheritance across mitotic cell division.
AB - Propagation of the chromatin landscape across cell divisions is central to epigenetic cell memory. Mechanistic analysis of the interplay between DNA replication, the cell cycle, and the epigenome has provided insights into replication-coupled chromatin assembly and post-replicative chromatin maintenance. These breakthroughs are critical for defining how proliferation impacts the epigenome during cell identity changes in development and disease. Here we review these findings in the broader context of epigenetic inheritance across mitotic cell division.
U2 - 10.1038/s41556-020-0487-y
DO - 10.1038/s41556-020-0487-y
M3 - Review
C2 - 32231312
VL - 22
SP - 361
EP - 371
JO - Nature Cell Biology
JF - Nature Cell Biology
SN - 1465-7392
ER -
ID: 239119586