Cell cycle regulation by feed-forward loops coupling transcription and phosphorylation

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Cell cycle regulation by feed-forward loops coupling transcription and phosphorylation. / Csikász-Nagy, Attila; Kapuy, Orsolya; Tóth, Attila; Pál, Csaba; Jensen, Lars Juhl; Uhlmann, Frank; Tyson, John J; Novák, Béla.

In: Molecular Systems Biology, Vol. 5, 2009, p. 236.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Csikász-Nagy, A, Kapuy, O, Tóth, A, Pál, C, Jensen, LJ, Uhlmann, F, Tyson, JJ & Novák, B 2009, 'Cell cycle regulation by feed-forward loops coupling transcription and phosphorylation', Molecular Systems Biology, vol. 5, pp. 236. https://doi.org/10.1038/msb.2008.73

APA

Csikász-Nagy, A., Kapuy, O., Tóth, A., Pál, C., Jensen, L. J., Uhlmann, F., Tyson, J. J., & Novák, B. (2009). Cell cycle regulation by feed-forward loops coupling transcription and phosphorylation. Molecular Systems Biology, 5, 236. https://doi.org/10.1038/msb.2008.73

Vancouver

Csikász-Nagy A, Kapuy O, Tóth A, Pál C, Jensen LJ, Uhlmann F et al. Cell cycle regulation by feed-forward loops coupling transcription and phosphorylation. Molecular Systems Biology. 2009;5:236. https://doi.org/10.1038/msb.2008.73

Author

Csikász-Nagy, Attila ; Kapuy, Orsolya ; Tóth, Attila ; Pál, Csaba ; Jensen, Lars Juhl ; Uhlmann, Frank ; Tyson, John J ; Novák, Béla. / Cell cycle regulation by feed-forward loops coupling transcription and phosphorylation. In: Molecular Systems Biology. 2009 ; Vol. 5. pp. 236.

Bibtex

@article{7968c8d07de411df928f000ea68e967b,
title = "Cell cycle regulation by feed-forward loops coupling transcription and phosphorylation",
abstract = "The eukaryotic cell cycle requires precise temporal coordination of the activities of hundreds of 'executor' proteins (EPs) involved in cell growth and division. Cyclin-dependent protein kinases (Cdks) play central roles in regulating the production, activation, inactivation and destruction of these EPs. From genome-scale data sets of budding yeast, we identify 126 EPs that are regulated by Cdk1 both through direct phosphorylation of the EP and through phosphorylation of the transcription factors that control expression of the EP, so that each of these EPs is regulated by a feed-forward loop (FFL) from Cdk1. By mathematical modelling, we show that such FFLs can activate EPs at different phases of the cell cycle depending of the effective signs (+ or -) of the regulatory steps of the FFL. We provide several case studies of EPs that are controlled by FFLs exactly as our models predict. The signal-transduction properties of FFLs allow one (or a few) Cdk signal(s) to drive a host of cell cycle responses in correct temporal sequence.",
author = "Attila Csik{\'a}sz-Nagy and Orsolya Kapuy and Attila T{\'o}th and Csaba P{\'a}l and Jensen, {Lars Juhl} and Frank Uhlmann and Tyson, {John J} and B{\'e}la Nov{\'a}k",
note = "Keywords: Cell Cycle; Cyclin-Dependent Kinases; Phosphorylation; Transcription Factors; Transcription, Genetic",
year = "2009",
doi = "10.1038/msb.2008.73",
language = "English",
volume = "5",
pages = "236",
journal = "Molecular Systems Biology",
issn = "1744-4292",
publisher = "Wiley-Blackwell",

}

RIS

TY - JOUR

T1 - Cell cycle regulation by feed-forward loops coupling transcription and phosphorylation

AU - Csikász-Nagy, Attila

AU - Kapuy, Orsolya

AU - Tóth, Attila

AU - Pál, Csaba

AU - Jensen, Lars Juhl

AU - Uhlmann, Frank

AU - Tyson, John J

AU - Novák, Béla

N1 - Keywords: Cell Cycle; Cyclin-Dependent Kinases; Phosphorylation; Transcription Factors; Transcription, Genetic

PY - 2009

Y1 - 2009

N2 - The eukaryotic cell cycle requires precise temporal coordination of the activities of hundreds of 'executor' proteins (EPs) involved in cell growth and division. Cyclin-dependent protein kinases (Cdks) play central roles in regulating the production, activation, inactivation and destruction of these EPs. From genome-scale data sets of budding yeast, we identify 126 EPs that are regulated by Cdk1 both through direct phosphorylation of the EP and through phosphorylation of the transcription factors that control expression of the EP, so that each of these EPs is regulated by a feed-forward loop (FFL) from Cdk1. By mathematical modelling, we show that such FFLs can activate EPs at different phases of the cell cycle depending of the effective signs (+ or -) of the regulatory steps of the FFL. We provide several case studies of EPs that are controlled by FFLs exactly as our models predict. The signal-transduction properties of FFLs allow one (or a few) Cdk signal(s) to drive a host of cell cycle responses in correct temporal sequence.

AB - The eukaryotic cell cycle requires precise temporal coordination of the activities of hundreds of 'executor' proteins (EPs) involved in cell growth and division. Cyclin-dependent protein kinases (Cdks) play central roles in regulating the production, activation, inactivation and destruction of these EPs. From genome-scale data sets of budding yeast, we identify 126 EPs that are regulated by Cdk1 both through direct phosphorylation of the EP and through phosphorylation of the transcription factors that control expression of the EP, so that each of these EPs is regulated by a feed-forward loop (FFL) from Cdk1. By mathematical modelling, we show that such FFLs can activate EPs at different phases of the cell cycle depending of the effective signs (+ or -) of the regulatory steps of the FFL. We provide several case studies of EPs that are controlled by FFLs exactly as our models predict. The signal-transduction properties of FFLs allow one (or a few) Cdk signal(s) to drive a host of cell cycle responses in correct temporal sequence.

U2 - 10.1038/msb.2008.73

DO - 10.1038/msb.2008.73

M3 - Journal article

C2 - 19156128

VL - 5

SP - 236

JO - Molecular Systems Biology

JF - Molecular Systems Biology

SN - 1744-4292

ER -

ID: 20418598