An Integrative Approach to Virus-Host Protein-Protein Interactions

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

Standard

An Integrative Approach to Virus-Host Protein-Protein Interactions. / Cook, Helen V.; Jensen, Lars Juhl.

Computational Cell Biology. ed. / Louise von Stechow; Alberto Santos Delgado. Humana Press, 2018. p. 175-196 (Methods in Molecular Biology, Vol. 1819).

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

Harvard

Cook, HV & Jensen, LJ 2018, An Integrative Approach to Virus-Host Protein-Protein Interactions. in L von Stechow & AS Delgado (eds), Computational Cell Biology. Humana Press, Methods in Molecular Biology, vol. 1819, pp. 175-196. https://doi.org/10.1007/978-1-4939-8618-7_8

APA

Cook, H. V., & Jensen, L. J. (2018). An Integrative Approach to Virus-Host Protein-Protein Interactions. In L. von Stechow, & A. S. Delgado (Eds.), Computational Cell Biology (pp. 175-196). Humana Press. Methods in Molecular Biology Vol. 1819 https://doi.org/10.1007/978-1-4939-8618-7_8

Vancouver

Cook HV, Jensen LJ. An Integrative Approach to Virus-Host Protein-Protein Interactions. In von Stechow L, Delgado AS, editors, Computational Cell Biology. Humana Press. 2018. p. 175-196. (Methods in Molecular Biology, Vol. 1819). https://doi.org/10.1007/978-1-4939-8618-7_8

Author

Cook, Helen V. ; Jensen, Lars Juhl. / An Integrative Approach to Virus-Host Protein-Protein Interactions. Computational Cell Biology. editor / Louise von Stechow ; Alberto Santos Delgado. Humana Press, 2018. pp. 175-196 (Methods in Molecular Biology, Vol. 1819).

Bibtex

@inbook{7021fbd71d8a4d7b8ca43c102ecb703f,
title = "An Integrative Approach to Virus-Host Protein-Protein Interactions",
abstract = "Since cell regulation and protein expression can be dramatically altered upon infection by viruses, studying the mechanisms by which viruses infect cells and the regulatory networks they disrupt is essential to understanding viral pathogenicity. This line of study can also lead to discoveries about the workings of host cells themselves. Computational methods are rapidly being developed to investigate viral-host interactions, and here we highlight recent methods and the insights that they have revealed so far, with a particular focus on methods that integrate different types of data. We also review the challenges of working with viruses compared with traditional cellular biology, and the limitations of current experimental and informatics methods.",
keywords = "Bioinformatics, Coevolution, Databases, Host prediction, Machine learning, Network rewiring, Orthology, PPI networks, Viral evolution, Viruses, Virus–host interactions",
author = "Cook, {Helen V.} and Jensen, {Lars Juhl}",
year = "2018",
doi = "10.1007/978-1-4939-8618-7_8",
language = "English",
isbn = "978-1-4939-8617-0",
series = "Methods in Molecular Biology",
publisher = "Humana Press",
pages = "175--196",
editor = "{von Stechow}, Louise and Delgado, {Alberto Santos}",
booktitle = "Computational Cell Biology",
address = "United States",

}

RIS

TY - CHAP

T1 - An Integrative Approach to Virus-Host Protein-Protein Interactions

AU - Cook, Helen V.

AU - Jensen, Lars Juhl

PY - 2018

Y1 - 2018

N2 - Since cell regulation and protein expression can be dramatically altered upon infection by viruses, studying the mechanisms by which viruses infect cells and the regulatory networks they disrupt is essential to understanding viral pathogenicity. This line of study can also lead to discoveries about the workings of host cells themselves. Computational methods are rapidly being developed to investigate viral-host interactions, and here we highlight recent methods and the insights that they have revealed so far, with a particular focus on methods that integrate different types of data. We also review the challenges of working with viruses compared with traditional cellular biology, and the limitations of current experimental and informatics methods.

AB - Since cell regulation and protein expression can be dramatically altered upon infection by viruses, studying the mechanisms by which viruses infect cells and the regulatory networks they disrupt is essential to understanding viral pathogenicity. This line of study can also lead to discoveries about the workings of host cells themselves. Computational methods are rapidly being developed to investigate viral-host interactions, and here we highlight recent methods and the insights that they have revealed so far, with a particular focus on methods that integrate different types of data. We also review the challenges of working with viruses compared with traditional cellular biology, and the limitations of current experimental and informatics methods.

KW - Bioinformatics

KW - Coevolution

KW - Databases

KW - Host prediction

KW - Machine learning

KW - Network rewiring

KW - Orthology

KW - PPI networks

KW - Viral evolution

KW - Viruses

KW - Virus–host interactions

U2 - 10.1007/978-1-4939-8618-7_8

DO - 10.1007/978-1-4939-8618-7_8

M3 - Book chapter

C2 - 30421404

SN - 978-1-4939-8617-0

T3 - Methods in Molecular Biology

SP - 175

EP - 196

BT - Computational Cell Biology

A2 - von Stechow, Louise

A2 - Delgado, Alberto Santos

PB - Humana Press

ER -

ID: 210011160