Age-stratified longitudinal study of Alzheimer's and vascular dementia patients

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Standard

Age-stratified longitudinal study of Alzheimer's and vascular dementia patients. / Jørgensen, Isabella Friis; Aguayo-Orozco, Alejandro; Lademann, Mette; Brunak, Søren.

In: Alzheimer's & Dementia, 2020, p. 908-917.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Jørgensen, IF, Aguayo-Orozco, A, Lademann, M & Brunak, S 2020, 'Age-stratified longitudinal study of Alzheimer's and vascular dementia patients', Alzheimer's & Dementia, pp. 908-917. https://doi.org/10.1002/alz.12091

APA

Jørgensen, I. F., Aguayo-Orozco, A., Lademann, M., & Brunak, S. (2020). Age-stratified longitudinal study of Alzheimer's and vascular dementia patients. Alzheimer's & Dementia, 908-917. https://doi.org/10.1002/alz.12091

Vancouver

Jørgensen IF, Aguayo-Orozco A, Lademann M, Brunak S. Age-stratified longitudinal study of Alzheimer's and vascular dementia patients. Alzheimer's & Dementia. 2020;908-917. https://doi.org/10.1002/alz.12091

Author

Jørgensen, Isabella Friis ; Aguayo-Orozco, Alejandro ; Lademann, Mette ; Brunak, Søren. / Age-stratified longitudinal study of Alzheimer's and vascular dementia patients. In: Alzheimer's & Dementia. 2020 ; pp. 908-917.

Bibtex

@article{205d4059d178444d854374837cadcd5c,
title = "Age-stratified longitudinal study of Alzheimer's and vascular dementia patients",
abstract = "INTRODUCTION: Similar symptoms, comorbidities and suboptimal diagnostic tests make the distinction between different types of dementia difficult, although this is essential for improved work-up and treatment optimization.METHODS: We calculated temporal disease trajectories of earlier multi-morbidities in Alzheimer's disease (AD) dementia and vascular dementia (VaD) patients using the Danish National Patient Registry covering all hospital encounters in Denmark (1994 to 2016). Subsequently, we reduced the comorbidity space dimensionality using a non-linear technique, uniform manifold approximation and projection.RESULTS: We found 49,112 and 24,101 patients that were diagnosed with AD or VaD, respectively. Temporal disease trajectories showed very similar disease patterns before the dementia diagnosis. Stratifying patients by age and reducing the comorbidity space to two dimensions, showed better discrimination between AD and VaD patients in early-onset dementia.DISCUSSION: Similar age-associated comorbidities, the phenomenon of mixed dementia, and misdiagnosis create great challenges in discriminating between classical subtypes of dementia.",
author = "J{\o}rgensen, {Isabella Friis} and Alejandro Aguayo-Orozco and Mette Lademann and S{\o}ren Brunak",
year = "2020",
doi = "10.1002/alz.12091",
language = "English",
pages = "908--917",
journal = "Alzheimer's & Dementia",
issn = "1552-5260",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Age-stratified longitudinal study of Alzheimer's and vascular dementia patients

AU - Jørgensen, Isabella Friis

AU - Aguayo-Orozco, Alejandro

AU - Lademann, Mette

AU - Brunak, Søren

PY - 2020

Y1 - 2020

N2 - INTRODUCTION: Similar symptoms, comorbidities and suboptimal diagnostic tests make the distinction between different types of dementia difficult, although this is essential for improved work-up and treatment optimization.METHODS: We calculated temporal disease trajectories of earlier multi-morbidities in Alzheimer's disease (AD) dementia and vascular dementia (VaD) patients using the Danish National Patient Registry covering all hospital encounters in Denmark (1994 to 2016). Subsequently, we reduced the comorbidity space dimensionality using a non-linear technique, uniform manifold approximation and projection.RESULTS: We found 49,112 and 24,101 patients that were diagnosed with AD or VaD, respectively. Temporal disease trajectories showed very similar disease patterns before the dementia diagnosis. Stratifying patients by age and reducing the comorbidity space to two dimensions, showed better discrimination between AD and VaD patients in early-onset dementia.DISCUSSION: Similar age-associated comorbidities, the phenomenon of mixed dementia, and misdiagnosis create great challenges in discriminating between classical subtypes of dementia.

AB - INTRODUCTION: Similar symptoms, comorbidities and suboptimal diagnostic tests make the distinction between different types of dementia difficult, although this is essential for improved work-up and treatment optimization.METHODS: We calculated temporal disease trajectories of earlier multi-morbidities in Alzheimer's disease (AD) dementia and vascular dementia (VaD) patients using the Danish National Patient Registry covering all hospital encounters in Denmark (1994 to 2016). Subsequently, we reduced the comorbidity space dimensionality using a non-linear technique, uniform manifold approximation and projection.RESULTS: We found 49,112 and 24,101 patients that were diagnosed with AD or VaD, respectively. Temporal disease trajectories showed very similar disease patterns before the dementia diagnosis. Stratifying patients by age and reducing the comorbidity space to two dimensions, showed better discrimination between AD and VaD patients in early-onset dementia.DISCUSSION: Similar age-associated comorbidities, the phenomenon of mixed dementia, and misdiagnosis create great challenges in discriminating between classical subtypes of dementia.

U2 - 10.1002/alz.12091

DO - 10.1002/alz.12091

M3 - Journal article

C2 - 32342671

SP - 908

EP - 917

JO - Alzheimer's & Dementia

JF - Alzheimer's & Dementia

SN - 1552-5260

ER -

ID: 240408061