A side effect resource to capture phenotypic effects of drugs
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A side effect resource to capture phenotypic effects of drugs. / Kuhn, Michael; Campillos, Monica; Letunic, Ivica; Jensen, Lars Juhl; Bork, Peer.
In: Molecular Systems Biology, Vol. 6, 01.01.2010, p. 343.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - A side effect resource to capture phenotypic effects of drugs
AU - Kuhn, Michael
AU - Campillos, Monica
AU - Letunic, Ivica
AU - Jensen, Lars Juhl
AU - Bork, Peer
PY - 2010/1/1
Y1 - 2010/1/1
N2 - The molecular understanding of phenotypes caused by drugs in humans is essential for elucidating mechanisms of action and for developing personalized medicines. Side effects of drugs (also known as adverse drug reactions) are an important source of human phenotypic information, but so far research on this topic has been hampered by insufficient accessibility of data. Consequently, we have developed a public, computer-readable side effect resource (SIDER) that connects 888 drugs to 1450 side effect terms. It contains information on frequency in patients for one-third of the drug-side effect pairs. For 199 drugs, the side effect frequency of placebo administration could also be extracted. We illustrate the potential of SIDER with a number of analyses. The resource is freely available for academic research at http://sideeffects.embl.de.
AB - The molecular understanding of phenotypes caused by drugs in humans is essential for elucidating mechanisms of action and for developing personalized medicines. Side effects of drugs (also known as adverse drug reactions) are an important source of human phenotypic information, but so far research on this topic has been hampered by insufficient accessibility of data. Consequently, we have developed a public, computer-readable side effect resource (SIDER) that connects 888 drugs to 1450 side effect terms. It contains information on frequency in patients for one-third of the drug-side effect pairs. For 199 drugs, the side effect frequency of placebo administration could also be extracted. We illustrate the potential of SIDER with a number of analyses. The resource is freely available for academic research at http://sideeffects.embl.de.
KW - Adverse Drug Reaction Reporting Systems
KW - Data Mining
KW - Databases as Topic
KW - Drug Therapy
KW - Humans
KW - Internet
KW - Pharmaceutical Preparations
KW - Phenotype
KW - Risk Assessment
KW - Structure-Activity Relationship
U2 - 10.1038/msb.2009.98
DO - 10.1038/msb.2009.98
M3 - Journal article
C2 - 20087340
VL - 6
SP - 343
JO - Molecular Systems Biology
JF - Molecular Systems Biology
SN - 1744-4292
ER -
ID: 33748583