A chromatin-based signalling mechanism directs the switch from mutagenic to error-free repair of DNA double strand breaks
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- A chromatin-based signalling mechanism directs the switch from mutagenic to error-free repair of DNA double strand breaks
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Mutations caused by DNA damage are a main driver of cancer. We discovered that recognition of newly synthesised histone H4 directs breast cancer type 1 susceptibility protein (BRCA1) to post-replicative chromatin. The switch from mutagenic to error-free DNA double strand break repair by homologous recombination is therefore controlled by chromatin.
| Original language | English |
|---|---|
| Article number | 1605820 |
| Journal | Molecular & Cellular Oncology |
| Volume | 6 |
| Issue number | 4 |
| Number of pages | 3 |
| ISSN | 2372-3556 |
| DOIs | |
| Publication status | Published - 2019 |
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