Niels Mailand

Niels Mailand

Professor, head of research, Professor

Member of:

    ORCID: 0000-0002-6623-709X

    Publication year:
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    1 - 50 out of 91Page size: 50
    1. 2000

    2. Involvement of Myc activity in a G(1)/S-promoting mechanism parallel to the pRb/E2F pathway

      Santoni Rugiu, Eric, Falck, J., Mailand, Niels, Bartek, J. & Lukas, Jiri, May 2000, In: Molecular and Cellular Biology. 20, 10, p. 3497-509 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Rapid destruction of human Cdc25A in response to DNA damage

      Mailand, Niels, Falck, J., Lukas, Claudia, Syljuåsen, R. G., Welcker, M., Bartek, J. & Lukas, Jiri, 26 May 2000, In: Science (New York, N.Y.). 288, 5470, p. 1425-9 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. 2001

    5. The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis

      Falck, J., Mailand, Niels, Syljuåsen, R. G., Bartek, J. & Lukas, Jiri, 12 Apr 2001, In: Nature. 410, 6830, p. 842-7 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. DNA damage-activated kinase Chk2 is independent of proliferation or differentiation yet correlates with tissue biology

      Lukas, Claudia, Bartkova, J., Latella, L., Falck, J., Mailand, Niels, Schroeder, T., Sehested, M., Lukas, Jiri & Bartek, J., 1 Jul 2001, In: Cancer Research. 61, 13, p. 4990-3 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. 2002

    8. Regulation of G(2)/M events by Cdc25A through phosphorylation-dependent modulation of its stability.

      Mailand, Niels, Podtelejnikov, A. V., Groth, Anja, Mann, M., Bartek, J. & Lukas, Jiri, 2002, In: EMBO Journal. 21, 21, p. 5911-20 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation

      Mailand, Niels, Lukas, Claudia, Kaiser, B. K., Jackson, P. K., Bartek, J. & Lukas, Jiri, Apr 2002, In: Nature Cell Biology. 4, 4, p. 317-22 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. 2004

    11. Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase

      Krämer, A., Mailand, Niels, Lukas, Claudia, Syljuåsen, R. G., Wilkinson, C. J., Nigg, E. A., Bartek, J. & Lukas, Jiri, Sep 2004, In: Nature Cell Biology. 6, 9, p. 884-91 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. 2005

    13. CDKs promote DNA replication origin licensing in human cells by protecting Cdc6 from APC/C-dependent proteolysis

      Mailand, Niels & Diffley, J. F. X., 23 Sep 2005, In: Cell. 122, 6, p. 915-26 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. 2006

    15. Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation

      Liu, S., Bekker-Jensen, Simon Holst, Mailand, Niels, Lukas, Claudia, Bartek, J. & Lukas, Jiri, 2006, In: Molecular and Cellular Biology. 26, 16, p. 6056-64 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress

      Mailand, Niels, Bekker-Jensen, Simon Holst, Bartek, J. & Lukas, Jiri, 2006, In: Molecular Cell. 23, 3, p. 307-18 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. The replication kinase Cdc7-Dbf4 promotes the interaction of the p150 subunit of chromatin assembly factor 1 with proliferating cell nuclear antigen

      Gérard, A., Koundrioukoff, S., Ramillon, V., Sergère, J., Mailand, Niels, Quivy, J. & Almouzni, G., 2006, In: E M B O Reports. 7, 8, p. 817-23 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. TOPping up ATR activity

      Bartek, J. & Mailand, Niels, 10 Mar 2006, In: Cell. 124, 5, p. 888-90 3 p.

      Research output: Contribution to journal › Comment/debate › Research › peer-review

    19. 2007

    20. RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins

      Mailand, Niels, Bekker-Jensen, Simon Holst, Faustrup, H., Melander, F., Bartek, J., Lukas, Claudia & Lukas, Jiri, 2007, In: Cell. 131, 5, p. 887-900 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Published

      Human Xip1 (C2orf13) is a novel regulator of cellular responses to DNA strand breaks

      Bekker-Jensen, Simon Holst, Fugger, K., Danielsen, J. R., Gromova, I., Sehested, M., Celis, J., Bartek, J., Lukas, Jiri & Mailand, Niels, 6 Jul 2007, In: Journal of Biological Chemistry. 282, 27, p. 19638-43 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. 2008

    23. Phosphorylation of SDT repeats in the MDC1 N terminus triggers retention of NBS1 at the DNA damage-modified chromatin

      Melander, F., Bekker-Jensen, Simon Holst, Falck, J., Bartek, J., Mailand, Niels & Lukas, Jiri, 21 Apr 2008, In: Journal of Cell Biology. 181, 2, p. 213-26 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. 2009

    25. Human Fbh1 helicase contributes to genome maintenance via pro- and anti-recombinase activities

      Fugger, K., Mistrik, M., Danielsen, J. R., Dinant, C., Falck, J., Bartek, J., Lukas, Jiri & Mailand, Niels, 2009, In: Journal of Cell Biology. 186, 5, p. 655-63 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. Nucleotide excision repair-induced H2A ubiquitination is dependent on MDC1 and RNF8 and reveals a universal DNA damage response

      Marteijn, J. A., Bekker-Jensen, Simon Holst, Mailand, Niels, Lans, H., Schwertman, P., Gourdin, A. M., Dantuma, N. P., Lukas, Jiri & Vermeulen, W., 2009, In: Journal of Cell Biology. 186, 6, p. 835-47 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    27. RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins

      Doil, C., Mailand, Niels, Bekker-Jensen, Simon Holst, Ménard, Patrice, Larsen, D. H., Pepperkok, R., Ellenberg, J., Panier, S., Durocher, D., Bartek, J., Lukas, Jiri & Lukas, Claudia, 2009, In: Cell. 136, 3, p. 435-46 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    28. USP7 counteracts SCFbetaTrCP- but not APCCdh1-mediated proteolysis of Claspin

      Faustrup, H., Bekker-Jensen, Simon Holst, Bartek, J., Lukas, Jiri & Mailand, Niels, 2009, In: Journal of Cell Biology. 184, 1, p. 13-9 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. 2010

    30. HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes

      Bekker-Jensen, Simon Holst, Danielsen, J. M. R., Fugger, K., Gromova, I., Nerstedt, A., Bartek, J., Lukas, Jiri & Mailand, Niels, 2010, In: Nature Cell Biology. 12, 1, p. 80-6; sup pp 1-12

      Research output: Contribution to journal › Letter › Research › peer-review

    31. Human Cdc14A phosphatase modulates the G2/M transition through Cdc25A and Cdc25B

      Vázquez-Novelle, M. D., Mailand, Niels, Ovejero, S., Bueno, A. & Sacristán, M. P., 2010, In: Journal of Biological Chemistry. 285, 52, p. 40544-53 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    32. Published

      Assembly and function of DNA double-strand break repair foci in mammalian cells

      Bekker-Jensen, Simon Holst & Mailand, Niels, 10 Dec 2010, In: D N A Repair. 9, 12, p. 1219-28 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. 2011
    34. Published

      The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaks

      Meerang, M., Ritz, D., Paliwal, S., Garajova, Z., Bosshard, M., Mailand, Niels, Janscak, P., Hübscher, U., Meyer, H. & Ramadan, K., 2011, In: Nature Cell Biology. 13, 11, p. 1376-82 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. Published

      Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level

      Danielsen, J. M. R., Sylvestersen, K. B., Bekker-Jensen, Simon Holst, Szklarczyk, D., Poulsen, J. W., Horn, H., Jensen, Lars Juhl, Mailand, Niels & Nielsen, Michael Lund, 1 Mar 2011, In: Molecular and Cellular Proteomics. 10, 3, p. M110.003590

      Research output: Contribution to journal › Journal article › Research › peer-review

    36. Published

      The ubiquitin- and SUMO-dependent signaling response to DNA double-strand breaks

      Bekker-Jensen, Simon Holst & Mailand, Niels, 12 Jun 2011, In: FEBS Letters. 585, p. 2914-2919 6 p.

      Research output: Contribution to journal › Review › Research › peer-review

    37. 2012
    38. Published

      A new non-catalytic role for ubiquitin ligase RNF8 in unfolding higher-order chromatin structure

      Luijsterburg, M. S., Acs, K., Ackermann, L., Wiegant, W. W., Bekker-Jensen, Simon Holst, Larsen, D. H., Khanna, K. K., van Attikum, H., Mailand, Niels & Dantuma, N. P., 2012, In: E M B O Journal. 31, 11, p. 2511-27 17 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    39. Published

      DNA damage-inducible SUMOylation of HERC2 promotes RNF8 binding via a novel SUMO-binding Zinc finger

      Danielsen, J. M. R., Povlsen, L. K., Villumsen, B. H., Streicher, W., Nilsson, Jakob, Wikström, M., Bekker-Jensen, Simon Holst & Mailand, Niels, 2012, In: Journal of Cell Biology. 197, 2, p. 179-87 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    40. Published

      DVC1 (C1orf124) is a DNA damage-targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocks

      Mosbech, A., Gibbs-Seymour, I., Kagias, K., Thorslund, T., Beli, P., Povlsen, L., Nielsen, S. V., Smedegaard, S., Sedgwick, G., Lukas, Claudia, Hartmann-Petersen, Rasmus, Lukas, Jiri, Choudhary, Chunaram, Pocock, R. D. J., Bekker-Jensen, Simon Holst & Mailand, Niels, 2012, In: Nature Structural and Molecular Biology. 19, 11, p. 1084-92 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    41. Published

      Human RNF169 is a negative regulator of the ubiquitin-dependent response to DNA double-strand breaks

      Poulsen, M., Lukas, C., Lukas, J., Bekker-Jensen, Simon Holst & Mailand, Niels, 2012, In: Journal of Cell Biology. 197, 2, p. 189-99 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    42. Published

      ICLs: a chicken without an egg

      Bekker-Jensen, Simon Holst & Mailand, Niels, 2012, In: Nature Reviews. Molecular Cell Biology. 13, 6, p. 342

      Research output: Contribution to journal › Review › Research › peer-review

    43. Published

      RNF8 and RNF168 but not HERC2 are required for DNA damage-induced ubiquitylation in chicken DT40 cells

      Østergaard, Vibe Hallundbæk, Pentzold, C., Pedersen, R. T., Iosif, S., Alpi, A., Bekker-Jensen, Simon Holst, Mailand, Niels & Lisby, Michael, 2012, In: D N A Repair. 11, 11, p. 892–905 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. Published

      The Ubiquitin Ligase XIAP Recruits LUBAC for NOD2 Signaling in Inflammation and Innate Immunity

      Damgaard, R. B., Nachbur, U., Yabal, M., Wong, W. W., Fiil, Berthe Katrine, Kastirr, M., Rieser, E., Rickard, J. A., Bankovacki, A., Peschel, C., Ruland, J., Bekker-Jensen, Simon Holst, Mailand, Niels, Kaufmann, T., Strasser, A., Walczak, H., Silke, J., Jost, P. J. & Gyrd-Hansen, Mads, 2012, In: Molecular Cell. 46, 6, p. 746-58 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    45. Published

      TRIP12 and UBR5 Suppress Spreading of Chromatin Ubiquitylation at Damaged Chromosomes

      Gudjónsson, Thorkell, Altmeyer, M. F., Savic, V., Toledo Lazaro, L. I., Dinant, C., Grøfte, M., Bartkova, J., Poulsen, M., Oka, Y., Bekker-Jensen, Simon Holst, Mailand, Niels, Neumann, B., Heriche, J., Shearer, R., Saunders, D., Bartek, J., Lukas, Jiri & Lukas, Claudia, 17 Aug 2012, In: Cell. 150, 4, p. 697-709 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    46. Published

      Ubiquitin and the DNA damage response: a new handle on histones

      Bekker-Jensen, Simon Holst & Mailand, Niels, 1 Sep 2012, In: Cell Cycle. 11, 17, p. 3153 1 p.

      Research output: Contribution to journal › Comment/debate › Research › peer-review

    47. Published

      Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass

      Povlsen, L. K., Beli, P., Wagner, S. A., Poulsen, S. L., Sylvestersen, K. B., Poulsen, J. W., Nielsen, Michael Lund, Bekker-Jensen, Simon Holst, Mailand, Niels & Choudhary, Chunaram, Oct 2012, In: Nature Cell Biology. 14, 10, p. 1089-98 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    48. 2013
    49. Published

      Poly(ADP-ribosyl)ation links the chromatin remodeler SMARCA5/SNF2H to RNF168-dependent DNA damage signaling

      Smeenk, G., Wiegant, W. W., Luijsterburg, M. S., Costelloe, T., Romeijn, R. J., Pastink, A., van Attikum, H., Marteijn, J. A., Vermeulen, W., Sroczynski, N. & Mailand, Niels, 15 Feb 2013, In: Journal of Cell Science. 126, 4, p. 889-903 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    50. Published

      The deubiquitylating enzyme USP44 counteracts the DNA double-strand break response mediated by the RNF8 and RNF168 ubiquitin ligases

      Mosbech, A., Lukas, Claudia, Bekker-Jensen, Simon Holst & Mailand, Niels, 24 Apr 2013, In: Journal of Biological Chemistry. 288, p. 16579-16587 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    51. Published

      Regulation of PCNA-protein interactions for genome stability

      Mailand, Niels, Gibbs-Seymour, I. & Bekker-Jensen, Simon Holst, May 2013, In: Nature Reviews. Molecular Cell Biology. 14, 5, p. 269-82 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    52. Published

      RNF111/Arkadia is a SUMO-targeted ubiquitin ligase that facilitates the DNA damage response

      Poulsen, S. L., Hansen, R. K., Wagner, S. A., van Cuijk, L., van Belle, G. J., Streicher, W., Wikström, M., Choudhary, Chunaram, Houtsmuller, A. B., Marteijn, J. A., Bekker-Jensen, Simon Holst & Mailand, Niels, 10 Jun 2013, In: Journal of Cell Biology. 201, 6, p. 797-807 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    53. Published

      OTULIN Restricts Met1-Linked Ubiquitination to Control Innate Immune Signaling

      Fiil, Berthe Katrine, Damgaard, R. B., Wagner, S. A., Keusekotten, K., Fritsch, M., Bekker-Jensen, Simon Holst, Mailand, Niels, Choudhary, Chunaram, Komander, D. & Gyrd-Hansen, Mads, 27 Jun 2013, In: Molecular Cell. 50, 6, p. 818-30 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    54. Published

      Disease-causing mutations in the XIAP BIR2 domain impair NOD2-dependent immune signalling

      Damgaard, R. B., Fiil, Berthe Katrine, Speckmann, C., Yabal, M., Stadt, U. Z., Bekker-Jensen, Simon Holst, Jost, P. J., Ehl, S., Mailand, Niels & Gyrd-Hansen, Mads, 1 Jul 2013, In: E M B O Journal. 5, p. 1278-1295 18 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    55. Published

      A new cellular stress response that triggers centriolar satellite reorganization and ciliogenesis

      Villumsen, B. H., Danielsen, J. R., Povlsen, L., Sylvestersen, K. B., Merdes, A., Beli, P., Yang, Y., Choudhary, Chunaram, Nielsen, Michael Lund, Mailand, Niels & Bekker-Jensen, Simon Holst, 11 Oct 2013, In: E M B O Journal. 32, 23, p. 3029-3040

      Research output: Contribution to journal › Journal article › Research › peer-review

    56. Published

      ATR-Chk1-APC/C-dependent stabilization of Cdc7-ASK (Dbf4) kinase is required for DNA lesion bypass under replication stress

      Yamada, M., Watanabe, K., Mistrik, M., Vesela, E., Protivankova, I., Mailand, Niels, Lee, M. H., Masai, H., Lukas, Jiri & Bartek, J., 15 Nov 2013, In: Genes & Development. 27, 22, p. 2459-2472 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    57. Published

      ATR Prohibits Replication Catastrophe by Preventing Global Exhaustion of RPA

      Toledo Lazaro, L. I., Altmeyer, M., Rask, M., Lukas, Claudia, Larsen, D. H., Povlsen, L. K., Bekker-Jensen, Simon Holst, Mailand, Niels, Bartek, J. & Lukas, Jiri, 21 Nov 2013, In: Cell. 155, 5, p. 1088-1103 16 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    58. 2014
    59. Published

      Molecular basis and regulation of OTULIN-LUBAC interaction

      Elliott, P. R., Al-Saoudi, S. V., Marco-Casanova, P., Fiil, Berthe Katrine, Keusekotten, K., Mailand, Niels, Freund, S. M. V., Gyrd-Hansen, Mads & Komander, D., 2014, In: Molecular Cell. 54, 3, p. 335-348 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    60. Published

      UBL5 is essential for pre-mRNA splicing and sister chromatid cohesion in human cells

      Oka, Y., Varmark, H., Vitting-Seerup, K., Beli, P., Waage, J. E., Hakobyan, A., Mistrik, M., Choudhary, Chunaram, Rohde, M., Bekker-Jensen, Simon Holst & Mailand, Niels, 2014, In: E M B O Reports. 15, 9, p. 956-964 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    61. Published

      Ago2 facilitates Rad51 recruitment and DNA double-strand break repair by homologous recombination

      Gao, M., Wei, W., Li, M. H., Wu, Y., Ba, Z., Jin, K., Li, M., Liao, Y., Adhikari, S., Chong, Z., Zhang, T., Guo, C., Tang, T., Zhu, B., Xu, X., Mailand, Niels, Yang, Y., Qi, Y. & Danielsen, J. M. R., May 2014, In: Cell Research. 24, 5, p. 532-41 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    62. 2015
    63. Published

      Proteomics reveals dynamic assembly of repair complexes during bypass of DNA cross-links

      Räschle, M., Smeenk, G., Hansen, R. K., Temu, T., Oka, Y., Hein, M. Y., Nagaraj, N., Long, D. T., Walter, J. C., Hofmann, K., Storchova, Z., Cox, J., Bekker-Jensen, Simon Holst, Mailand, Niels & Mann, Matthias, 2015, In: Science. 348, 6234, p. 539- 10 p., 1253671.

      Research output: Contribution to journal › Journal article › Research › peer-review

    64. Published

      Centriolar satellites: key mediators of centrosome functions

      Tollenaere, M. A. X., Mailand, Niels & Bekker-Jensen, Simon Holst, Jan 2015, In: Cellular and molecular life sciences : CMLS. 73, 1, p. 11-23 13 p.

      Research output: Contribution to journal › Review › Research › peer-review

    65. Published

      Proteome-wide analysis of SUMO2 targets in response to pathological DNA replication stress in human cells

      Bursomanno, S., Beli, P., Khan, A. M., Minocherhomji, S., Wagner, S. A., Bekker-Jensen, Simon Holst, Mailand, Niels, Choudhary, Chunaram, Hickson, Ian David & Liu, Ying, Jan 2015, In: DNA Repair. 25, p. 84-96 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

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