Matthias Mann
Professor, head of research, Professor
- 2024
- E-pub ahead of print
Comparative quantitative proteomic analysis of melanoma subtypes, nevus-associated melanoma, and corresponding nevi
Naimy, S., Sølberg, J. B. K., Kuczek, D. E., Løvendorf, Marianne Bengtson, Bzorek, M., Litman, Thomas, Mund, Andreas, Gjerdrum, Lise Mette Rahbek, Clark, R. A., Mann, Matthias & Dyring-Andersen, Beatrice, 5 Jan 2024, (E-pub ahead of print) In: The Journal of Investigative Dermatology.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Artificial intelligence in mass spectrometry-based proteomics
Zeng, W. F., Mann, Matthias & Strauss, Maximilian, 2024, Artificial Intelligence in Clinical Practice: How AI Technologies Impact Medical Research and Clinics. Elsevier, p. 389-394 6 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Full Mass Range ΦSDM Orbitrap Mass Spectrometry for DIA Proteome Analysis
Steigerwald, S., Sinha, A., Fort, K. L., Zeng, W., Niu, Lili, Wichmann, C., Kreutzmann, A., Mourad, D., Aizikov, K., Grinfeld, D., Makarov, A., Mann, Matthias & Meier, F., 2024, In: Molecular and Cellular Proteomics. 12 p., 100713.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
In-Depth Proteomic Map of Innate Lymphoid Cells from Healthy Human Skin and Blood
Teunissen, M. B. M., Pilgaard Møller, L. B., Løvendorf, Marianne Bengtson, Skov, Lone, Bonefeld, Charlotte Menne, Bekkenk, M. W., Clark, R. A., Mann, Matthias & Dyring-Andersen, Beatrice, 2024, In: Journal of Investigative Dermatology. 144, 2, 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The NSP3 protein of SARS-CoV-2 binds fragile X mental retardation proteins to disrupt UBAP2L interactions
Garvanska, D. H., Alvarado, R. E., Mundt, F. O., Lindqvist, R., Duel, J. K., Coscia, F., Nilsson, E., Lokugamage, K., Johnson, B. A., Plante, J. A., Morris, D. R., Vu, M. N., Estes, L. K., McLeland, A. M., Walker, J., Crocquet-Valdes, P. A., Mendez, B. L., Plante, K. S., Walker, D. H., Weisser, M. B. & 4 others, , 2024, In: EMBO Reports.Research output: Contribution to journal › Journal article › Research › peer-review
- 2023
Unique ligand and kinase-independent roles of the insulin receptor in regulation of cell cycle, senescence and apoptosis
Nagao, H., Jayavelu, A. K., Cai, W., Pan, H., Dreyfuss, J. M., Batista, T. M., Brandão, B. B., Mann, Matthias & Kahn, C. R., 4 Jan 2023, In: Nature Communications. 14, 1, p. 57Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A Standardized and Reproducible Workflow for Membrane Glass Slides in Routine Histology and Spatial Proteomics
Nordmann, T. M., Schweizer, L., Metousis, A., Thielert, Marvin Christoffer, Rodriguez, E., Gjerdrum, Lise Mette Rahbek, Stadler, P., Bzorek, M., Mund, Andreas, Rosenberger, F. A. & Mann, Matthias, 2023, In: Molecular & cellular proteomics : MCP. 22, 10, 9 p., 100643.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A reversible state of hypometabolism in a human cellular model of sporadic Parkinson’s disease
Schmidt, S., Stautner, C., Vu, D. T., Heinz, A., Regensburger, M., Karayel, O., Trümbach, D., Artati, A., Kaltenhäuser, S., Nassef, M. Z., Hembach, S., Steinert, L., Winner, B., Jürgen, W., Jastroch, M., Luecken, M. D., Theis, F. J., Westmeyer, G. G., Adamski, J., Mann, M. & 4 others, , 2023, In: Nature Communications. 14, 1, 24 p., 7674.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A unified classification approach rating clinical utility of protein biomarkers across neurologic diseases
Bernhardt, A. M., Tiedt, S., Teupser, D., Dichgans, M., Meyer, B., Gempt, J., Kuhn, P. H., Simons, M., Palleis, C., Weidinger, E., Nübling, G., Holdt, L., Hönikl, L., Gasperi, C., Giesbertz, P., Müller, S. A., Breimann, S., Lichtenthaler, S. F., Kuster, B., Mann, M. & 8 others, , 2023, In: EBioMedicine. 89, 13 p., 104456.Research output: Contribution to journal › Review › Research › peer-review
- Published
Activity-based profiling of cullin–RING E3 networks by conformation-specific probes
Henneberg, L. T., Singh, J., Duda, D. M., Baek, K., Yanishevski, D., Murray, P. J., Mann, Matthias, Sidhu, S. S. & Schulman, B. A., 2023, In: Nature Chemical Biology. 19, p. 1513-1523Research output: Contribution to journal › Journal article › Research › peer-review
- Published
AlphaPeptStats: an open-source Python package for automated and scalable statistical analysis of mass spectrometry-based proteomics
Krismer, Elena, Bludau, I., Strauss, Maximilian & Mann, Matthias, 2023, In: Bioinformatics. 39, 8, 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Comprehensive chromatin proteomics resolves functional phases of pluripotency and identifies changes in regulatory components
Ugur, E., de la Porte, A., Qin, W., Bultmann, S., Ivanova, A., Drukker, M., Mann, Matthias, Wierer, M. & Leonhardt, H., 2023, In: Nucleic Acids Research. 51, 6, p. 2671-2690 20 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Consistency across multi-omics layers in a drug-perturbed gut microbial community
Wuyts, S., Alves, R., Zimmermann-Kogadeeva, M., Nishijima, S., Blasche, S., Driessen, M., Geyer, P. E., Hercog, R., Kartal, E., Maier, L., Müller, J. B., Garcia Santamarina, S., Schmidt, T. S. B., Sevin, D. C., Telzerow, A., Treit, P. V., Wenzel, T., Typas, A., Patil, K. R., Mann, M. & 2 others, , 2023, In: Molecular Systems Biology. 19, 9, 17 p., e11525.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cytosolic Ptbp2 modulates axon growth in motoneurons through axonal localization and translation of Hnrnpr
Salehi, S., Zare, A., Prezza, G., Bader, J., Schneider, C., Fischer, U., Meissner, F., Mann, Matthias, Briese, M. & Sendtner, M., 2023, In: Nature Communications. 14, 19 p., 4158.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Democratizing knowledge representation with BioCypher
Lobentanzer, S., Aloy, P., Baumbach, J., Bohar, B., Carey, V. J., Charoentong, P., Danhauser, K., Doğan, T., Dreo, J., Dunham, I., Farr, E., Fernandez-Torras, A., Gyori, B. M., Hartung, M., Hoyt, C. T., Klein, C., Korcsmaros, T., Maier, A., Mann, M., Ochoa, D. & 12 others, , 2023, In: Nature Biotechnology. 41, p. 1056-1059Research output: Contribution to journal › Letter › Research › peer-review
- Published
Foresight in clinical proteomics: current status, ethical considerations, and future perspectives
Mundt Madsen, Filip Oskar, Albrechtsen, Nicolai Jacob Wewer, Porsdam Mann, Sebastian, Treit, P., Ghodgaonkar-Steger, M., O’Flaherty, M., Raijmakers, R., Vizcaíno, J. A., Heck, A. J. R. & Mann, Matthias, 2023, In: Open Research Europe. 3, 19 p., 59.Research output: Contribution to journal › Letter › Research › peer-review
- Published
Leucine-973 is a crucial residue differentiating insulin and IGF-1 receptor signaling
Nagao, H., Cai, W., Brandão, B. B., Albrechtsen, Nicolai Jacob Wewer, Steger, M., Gattu, A. K., Pan, H., Dreyfuss, J. M., Thomas Wunderlich, F., Mann, Matthias & Ronald Kahn, C., 2023, In: Journal of Clinical Investigation. 133, 4, 18 p., e161472.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
MS-Based Proteomics of Body Fluids: The End of the Beginning
Bader, J. M., Albrecht, V. & Mann, Matthias, 2023, In: Molecular and Cellular Proteomics. 22, 7, 18 p., 100577.Research output: Contribution to journal › Review › Research › peer-review
- Published
Making single-cell proteomics biologically relevant
Rosenberger, F. A., Thielert, Marvin Christoffer & Mann, Matthias, 2023, In: Nature Methods. 20, p. 320-323 4 p.Research output: Contribution to journal › Comment/debate › Research
- Published
Plasma proteome profiling of healthy subjects undergoing bed rest reveals unloading-dependent changes linked to muscle atrophy
Murgia, M., Brocca, L., Monti, E., Franchi, M. V., Zwiebel, M., Steigerwald, S., Giacomello, E., Sartori, R., Zampieri, S., Capovilla, G., Gasparini, M., Biolo, G., Sandri, M., Mann, Matthias & Narici, M. V., 2023, In: Journal of Cachexia, Sarcopenia and Muscle. 14, p. 439-451Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Proteomic Profiling of Colorectal Adenomas Identifies a Predictive Risk Signature for Development of Metachronous Advanced Colorectal Neoplasia
Bech, J. M., Terkelsen, Thilde Bagger, Bartels, Annette Snejbjerg, Coscia, F., Doll, S., Zhao, S., Zhang, Z., Brünner, N., Lindebjerg, J., Madsen, G. I., Fang, X., Mann, Matthias & Moreira, José, 2023, In: Gastroenterology. 165, 1, p. 121-132.e5Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Proteomics separates adult-type diffuse high-grade gliomas in metabolic subgroups independent of 1p/19q codeletion and across IDH mutational status
Bader, J. M., Deigendesch, N., Misch, M., Mann, Matthias, Koch, A. & Meissner, F., 2023, In: Cell Reports Medicine. 4, 1, 100877.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Robust dimethyl-based multiplex-DIA doubles single-cell proteome depth via a reference channel
Thielert, M., Itang, E. C. M., Ammar, C., Rosenberger, F. A., Bludau, I., Schweizer, L., Nordmann, T. M., Skowronek, P., Wahle, M., Zeng, W. F., Zhou, X. X., Brunner, A. D., Richter, S., Levesque, M. P., Theis, F. J., Steger, M. & Mann, Matthias, 2023, In: Molecular Systems Biology. 19, 9, 23 p., e11503.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Spatial single-cell mass spectrometry defines zonation of the hepatocyte proteome
Rosenberger, F. A., Thielert, Marvin Christoffer, Strauss, Maximilian, Schweizer, L., Ammar, C., Mädler, S. C., Metousis, A., Skowronek, P., Wahle, M., Madden, K., Gote-Schniering, J., Semenova, A., Schiller, H. B., Rodriguez, E., Nordmann, T. M., Mund, Andreas & Mann, Matthias, 2023, In: Nature Methods. 20, 10, p. 1530-1536 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synchro-PASEF allows precursor-specific fragment ion extraction and interference removal in data-independent acquisition
Skowronek, P., Krohs, F., Lubeck, M., Wallmann, G., Itang, E. C. M., Koval, P., Wahle, M., Thielert, Marvin Christoffer, Meier, F., Willems, S., Raether, O. & Mann, Matthias, 2023, In: Molecular and Cellular Proteomics. 22, 2, 14 p., 100489.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Proteome of Hand Eczema Assessed by Tape Stripping
Sølberg, J. B. K., Quaade, A. S., Drici, L., Sulek, K., Ulrich, N. H., Løvendorf, Marianne Bengtson, Thyssen, Jacob Pontoppidan, Mann, Matthias, Dyring-Andersen, Beatrice & Johansen, Jeanne Duus, 2023, In: Journal of Investigative Dermatology. 143, p. 1559-1568Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The social and structural architecture of the yeast protein interactome
Michaelis, A. C., Brunner, A., Zwiebel, M., Meier, F., Strauss, Maximilian, Bludau, I. & Mann, Matthias, 2023, In: Nature. 624, 7990, p. 192-200 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2022
Analysis of RANK-c interaction partners identifies TRAF3 as a critical regulator of breast cancer aggressiveness
Sirinian, C., Papanastasiou, A. D., Karayel, O., Degn, S. E., Peroukidis, S., Chaniotis, D., Nonni, A., Repanti, M., Kriegsmann, M., Makatsoris, T., Koutras, A., Mann, Matthias & Kalofonos, H. P., Nov 2022, In: Neoplasia (New York, N.Y.). 33, p. 100836Research output: Contribution to journal › Journal article › Research › peer-review
Temporal resolution of gene derepression and proteome changes upon PROTAC-mediated degradation of BCL11A protein in erythroid cells
Mehta, S., Buyanbat, A., Kai, Y., Karayel, O., Goldman, S. R., Seruggia, D., Zhang, K., Fujiwara, Y., Donovan, K. A., Zhu, Q., Yang, H., Nabet, B., Gray, N. S., Mann, Matthias, Fischer, E. S., Adelman, K. & Orkin, S. H., 18 Aug 2022, In: Cell Chemical Biology. 29, 8, p. 1273-1287.e8Research output: Contribution to journal › Journal article › Research › peer-review
Gene-selective transcription promotes the inhibition of tissue reparative macrophages by TNF
Dichtl, S., Sanin, D. E., Koss, C. K., Willenborg, S., Petzold, A., Tanzer, M. C., Dahl, A., Kabat, A. M., Lindenthal, L., Zeitler, L., Satzinger, S., Strasser, A., Mann, Matthias, Roers, A., Eming, S. A., El Kasmi, K. C., Pearce, E. J. & Murray, P. J., Apr 2022, In: Life Science Alliance. 5, 4Research output: Contribution to journal › Journal article › Research › peer-review
Adverse stem cell clones within a single patient's tumor predict clinical outcome in AML patients
Zeller, C., Richter, D., Jurinovic, V., Valtierra-Gutiérrez, I. A., Jayavelu, A. K., Mann, Matthias, Bagnoli, J. W., Hellmann, I., Herold, T., Enard, W., Vick, B. & Jeremias, I., 12 Mar 2022, In: Journal of Hematology & Oncology. 15, 1, p. 25Research output: Contribution to journal › Journal article › Research › peer-review
Amyloid-like aggregating proteins cause lysosomal defects in neurons via gain-of-function toxicity
Riera-Tur, I., Schäfer, T., Hornburg, D., Mishra, A., da Silva Padilha, M., Fernández-Mosquera, L., Feigenbutz, D., Auer, P., Mann, Matthias, Baumeister, W., Klein, R., Meissner, F., Raimundo, N., Fernández-Busnadiego, R. & Dudanova, I., Mar 2022, In: Life Science Alliance. 5, 3Research output: Contribution to journal › Journal article › Research › peer-review
Phosphorylation of serine-893 in CARD11 suppresses the formation and activity of the CARD11-BCL10-MALT1 complex in T and B cells
Kutzner, K., Woods, S., Karayel, O., Gehring, T., Yin, H., Flatley, A., Graß, C., Wimberger, N., Tofaute, M. J., Seeholzer, T., Feederle, R., Mann, Matthias & Krappmann, D., Mar 2022, In: Science Signaling. 15, 723, p. eabk3083Research output: Contribution to journal › Journal article › Research › peer-review
YBX1 mediates translation of oncogenic transcripts to control cell competition in AML
Perner, F., Schnoeder, T. M., Xiong, Y., Jayavelu, A. K., Mashamba, N., Santamaria, N. T., Huber, N., Todorova, K., Hatton, C., Perner, B., Eifert, T., Murphy, C., Hartmann, M., Hoell, J. I., Schröder, N., Brandt, S., Hochhaus, A., Mertens, P. R., Mann, M., Armstrong, S. A. & 2 others, , Feb 2022, In: Leukemia. 36, 2, p. 426-437 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
A20 and ABIN-1 cooperate in balancing CBM complex-triggered NF-κB signaling in activated T cells
Yin, H., Karayel, O., Chao, Y., Seeholzer, T., Hamp, I., Plettenburg, O., Gehring, T., Zielinski, C., Mann, Matthias & Krappmann, D., 31 Jan 2022, In: Cellular and Molecular Life Sciences. 79, 2, p. 112Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A knowledge graph to interpret clinical proteomics data
Santos, A., Colaço, A. R., Nielsen, A. B., Niu, Lili, Strauss, Maximilian, Geyer, P. E., Coscia, F., Albrechtsen, Nicolai Jacob Wewer, Mundt, F., Jensen, Lars Juhl & Mann, Matthias, 2022, In: Nature Biotechnology. 40, p. 692–702Research output: Contribution to journal › Journal article › Research › peer-review
- Published
AlphaMap: an open-source Python package for the visual annotation of proteomics data with sequence-specific knowledge
Voytik, E., Bludau, I., Willems, S., Hansen, F. M., Brunner, A., Strauss, Maximilian & Mann, Matthias, 2022, In: Bioinformatics. 38, 3, p. 849-852Research output: Contribution to journal › Journal article › Research › peer-review
- Published
AlphaPeptDeep: a modular deep learning framework to predict peptide properties for proteomics
Zeng, W. F., Zhou, X. X., Willems, S., Ammar, C., Wahle, M., Bludau, I., Voytik, E., Strauss, Maximilian & Mann, Matthias, 2022, In: Nature Communications. 13, 14 p., 7238.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Association of Complement and MAPK Activation With SARS-CoV-2-Associated Myocardial Inflammation
Weckbach, L. T., Schweizer, L., Kraechan, A., Bieber, S., Ishikawa-Ankerhold, H., Hausleiter, J., Massberg, S., Straub, T., Klingel, K., Grabmaier, U., Zwiebel, M., Mann, Matthias & Schulz, C., 2022, In: JAMA Cardiology. 7, 3, p. 286-297 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
Cotranslational N-degron masking by acetylation promotes proteome stability in plants
Linster, E., Forero Ruiz, F. L., Miklankova, P., Ruppert, T., Mueller, J., Armbruster, L., Gong, X., Serino, G., Mann, Matthias, Hell, R. & Wirtz, M., 2022, In: Nature Communications. 13, 1, p. 810Research output: Contribution to journal › Journal article › Research › peer-review
Cryo-EM structures of Gid12-bound GID E3 reveal steric blockade as a mechanism inhibiting substrate ubiquitylation
Qiao, S., Lee, C., Sherpa, D., Chrustowicz, J., Cheng, J., Duennebacke, M., Steigenberger, B., Karayel, O., Vu, D. T., von Gronau, S., Mann, Matthias, Wilfling, F. & Schulman, B. A., 2022, In: Nature Communications. 13, 3041.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
D13 Saliva biomarker discovery in Huntington’s disease
Qvist, Filippa Liliendahl, Hellem, M. N., Nielsen, Jørgen Erik, Mann, Matthias & Skotte, Niels Henning, 2022, In: Journal of Neurology, Neurosurgery and Psychiatry. 93, Suppl. 1, p. A24-A25Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
Deep Visual Proteomics defines single-cell identity and heterogeneity
Mund, A., Coscia, F., Kriston, A., Hollandi, R., Kovács, F., Brunner, A-D., Migh, E., Schweizer, L., Santos, A., Bzorek, M., Naimy, S., Rahbek-Gjerdrum, L. M., Dyring-Andersen, B., Bulkescher, J., Lukas, C., Eckert, M. A., Lengyel, E., Gnann, C., Lundberg, E., Horvath, P. & 1 others, , 2022, In: Nature Biotechnology. 40, p. 1231-1240Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Dynamic human liver proteome atlas reveals functional insights into disease pathways
Niu, Lili, Geyer, P. E., Gupta, R., Santos, A., Meier, F., Doll, S., Albrechtsen, Nicolai Jacob Wewer, Klein, S., Ortiz, C., Uschner, F. E., Schierwagen, R., Trebicka, J. & Mann, Matthias, 2022, In: Molecular Systems Biology. 18, 5, 24 p., e10947.Research output: Contribution to journal › Journal article › Research › peer-review
Gel-like inclusions of C-terminal fragments of TDP-43 sequester stalled proteasomes in neurons
Riemenschneider, H., Guo, Q., Bader, J., Frottin, F., Farny, D., Kleinberger, G., Haass, C., Mann, Matthias, Hartl, F. U., Baumeister, W., Hipp, M. S., Meissner, F., Fernández-Busnadiego, R. & Edbauer, D., 2022, In: EMBO Reports. 23, 6, e53890.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
HYPK promotes the activity of the Nα-acetyltransferase A complex to determine proteostasis of nonAc-X2/N-degron-containing proteins
Miklánková, P., Linster, E., Boyer, J., Weidenhausen, J., Mueller, J., Armbruster, L., Lapouge, K., De La Torre, C., Bienvenut, W., Sticht, C., Mann, Matthias, Meinnel, T., Sinning, I., Giglione, C., Hell, R. & Wirtz, M., 2022, In: Science Advances. 8, 24, 14 p., eabn6153.Research output: Contribution to journal › Journal article › Research › peer-review
IKKβ primes inflammasome formation by recruiting NLRP3 to the trans-Golgi network
Schmacke, N. A., O'Duill, F., Gaidt, M. M., Szymanska, I., Kamper, J. M., Schmid-Burgk, J. L., Mädler, S. C., Mackens-Kiani, T., Kozaki, T., Chauhan, D., Nagl, D., Stafford, C. A., Harz, H., Fröhlich, A. L., Pinci, F., Ginhoux, F., Beckmann, R., Mann, Matthias, Leonhardt, H. & Hornung, V., 2022, In: Immunity. 55, 12, p. 2271-2284.e7Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of early neurodegenerative pathways in progressive multiple sclerosis
Kaufmann, M., Schaupp, A. L., Sun, R., Coscia, F., Dendrou, C. A., Cortes, A., Kaur, G., Evans, H. G., Mollbrink, A., Navarro, J. F., Sonner, J. K., Mayer, C., DeLuca, G. C., Lundeberg, J., Matthews, P. M., Attfield, K. E., Friese, M. A., Mann, Matthias & Fugger, Lars, 2022, In: Nature Neuroscience. 25, p. 944-955Research output: Contribution to journal › Journal article › Research › peer-review
In vivo PDX CRISPR/Cas9 screens reveal mutual therapeutic targets to overcome heterogeneous acquired chemo-resistance
Wirth, A-K., Wange, L., Vosberg, S., Henrich, K-O., Rausch, C., Özdemir, E., Zeller, C. M., Richter, D., Feuchtinger, T., Kaller, M., Hermeking, H., Greif, P. A., Senft, D., Jurinovic, V., Bahrami, E., Jayavelu, A. K., Westermann, F., Mann, M., Enard, W., Herold, T. & 1 others, , 2022, In: Leukemia. 36, p. 2863-2874 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mast cells in lung damage of COVID-19 autopsies: A descriptive study
Schaller, T., Märkl, B., Claus, R., Sholl, L., Hornick, J. L., Giannetti, M. P., Schweizer, L., Mann, Matthias & Castells, M., 2022, In: Allergy. 77, 7, p. 2237-2239 3 p.Research output: Contribution to journal › Comment/debate › Research
- Published
Noninvasive proteomic biomarkers for alcohol-related liver disease
Niu, Lili, Thiele, M., Geyer, P. E., Rasmussen, D. N., Webel, Henry, Santos, A., Gupta, R., Meier, F., Strauss, Maximilian, Kjaergaard, M., Lindvig, K., Jacobsen, S., Rasmussen, Simon, Hansen, Torben, Krag, A. & Mann, Matthias, 2022, In: Nature Medicine. 28, 6, p. 1277-1287 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
OpenCell: Endogenous tagging for the cartography of human cellular organization
Cho, N. H., Cheveralls, K. C., Brunner, A. D., Kim, K., Michaelis, A. C., Raghavan, P., Kobayashi, H., Savy, L., Li, J. Y., Canaj, H., Kim, J. Y. S., Stewart, E. M., Gnann, C., McCarthy, F., Cabrera, J. P., Brunetti, R. M., Chhun, B. B., Dingle, G., Hein, M. Y., Huang, B. & 7 others, , 2022, In: Science. 375, 6585, eabi6983.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Organ-specific metabolic pathways distinguish prediabetes, type 2 diabetes, and normal tissues
Diamanti, K., Cavalli, M., Pereira, M. J., Pan, G., Castillejo-López, C., Kumar, C., Mundt Madsen, Filip Oskar, Komorowski, J., Deshmukh, Atul Shahaji, Mann, Matthias, Korsgren, O., Eriksson, J. W. & Wadelius, C., 2022, In: Cell Reports Medicine. 3, 10, 21 p., 100763.Research output: Contribution to journal › Journal article › Research › peer-review
PLCG1 is required for AML1-ETO leukemia stem cell self-renewal
Schnoeder, T. M., Schwarzer, A., Jayavelu, A. K., Hsu, C-J., Kirkpatrick, J., Döhner, K., Perner, F., Eifert, T., Huber, N., Arreba-Tutusaus, P., Dolnik, A., Assi, S. A., Nafria, M., Jiang, L., Dai, Y-T., Chen, Z., Chen, S-J., Kellaway, S. G., Ptasinska, A., Ng, E. S. & 17 others, , 2022, In: Blood. 139, 7, p. 1080-1097 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Phosphorylation of muramyl peptides by NAGK is required for NOD2 activation
Stafford, C. A., Gassauer, A. M., de Oliveira Mann, C. C., Tanzer, M. C., Fessler, E., Wefers, B., Nagl, D., Kuut, G., Sulek, K., Vasilopoulou, C., Schwojer, S. J., Wiest, A., Pfautsch, M. K., Wurst, W., Yabal, M., Fröhlich, T., Mann, Matthias, Gisch, N., Jae, L. T. & Hornung, V., 2022, In: Nature. 609, p. 590-596 28 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Proteome profiling of cerebrospinal fluid reveals biomarker candidates for Parkinson's disease
Karayel, O., Virreira Winter, S., Padmanabhan, S., Kuras, Y. I., Vu, D. T., Tuncali, I., Merchant, K., Wills, A. M., Scherzer, C. R. & Mann, Matthias, 2022, In: Cell Reports Medicine. 3, 6, 20 p., 100661.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Rapid and In-Depth Coverage of the (Phospho-)Proteome With Deep Libraries and Optimal Window Design for dia-PASEF
Skowronek, P., Thielert, Marvin Christoffer, Voytik, E., Tanzer, M. C., Hansen, F. M., Willems, S., Karayel, O., Brunner, A., Meier, F. & Mann, Matthias, 2022, In: Molecular and Cellular Proteomics. 21, 9, 15 p., 100279.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Spatial characterization of single tumor cells by proteomics
Mund, Andreas & Mann, Matthias, 2022, In: Nature Biotechnology. 40, 8, p. 1186-1187 2 p.Research output: Contribution to journal › Comment/debate › Research
- Published
Spatial proteomics in three-dimensional intact specimens
Bhatia, H. S., Brunner, A-D., Öztürk, F., Kapoor, S., Rong, Z., Mai, H., Thielert, M., Ali, M., Al-Maskari, R., Paetzold, J. C., Kofler, F., Todorov, M. I., Molbay, M., Kolabas, Z. I., Negwer, M., Hoeher, L., Steinke, H., Dima, A., Gupta, B., Kaltenecker, D. & 11 others, , 2022, In: Cell. 185, 26, p. 5040-5058.e19Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The emerging role of mass spectrometry-based proteomics in drug discovery
Meissner, F., Geddes-McAlister, J., Mann, Matthias & Bantscheff, M., 2022, In: Nature Reviews Drug Discovery. 21, p. 637-654 18 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
The structural context of posttranslational modifications at a proteome-wide scale
Bludau, I., Willems, S., Zeng, W. F., Strauss, Maximilian, Hansen, F. M., Tanzer, M. C., Karayel, O., Schulman, B. A. & Mann, Matthias, 2022, In: PLOS Biology. 20, 5, 23 p., e3001636.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Towards Precision Dermatology: Emerging Role of Proteomic Analysis of the Skin
Fredman, G., Skov, Lone, Mann, Matthias & Dyring-Andersen, Beatrice, 2022, In: Dermatology. 238, p. 185–194Research output: Contribution to journal › Review › Research › peer-review
- Published
Ultra-high sensitivity mass spectrometry quantifies single-cell proteome changes upon perturbation
Brunner, A., Thielert, Marvin Christoffer, Vasilopoulou, C., Ammar, C., Coscia, F., Mund, Andreas, Hoerning, O. B., Bache, N., Apalategui, A., Lubeck, M., Richter, S., Fischer, D. S., Raether, O., Park, M. A., Meier, F., Theis, F. J. & Mann, Matthias, 2022, In: Molecular Systems Biology. 18, 3, 15 p., e10798.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Unbiased spatial proteomics with single-cell resolution in tissues
Mund, Andreas, Brunner, A. & Mann, Matthias, 2022, In: Molecular Cell. 82, 12, p. 2335-2349 15 p.Research output: Contribution to journal › Review › Research › peer-review
- 2021
Proteomic Analysis Identifies NDUFS1 and ATP5O as Novel Markers for Survival Outcome in Prostate Cancer
Wiebringhaus, R., Pecoraro, M., Neubauer, H. A., Trachtová, K., Trimmel, B., Wieselberg, M., Pencik, J., Egger, G., Krall, C., Moriggl, R., Mann, Matthias, Hantusch, B. & Kenner, L., 30 Nov 2021, In: Cancers. 13, 23Research output: Contribution to journal › Journal article › Research › peer-review
Signaling defects associated with insulin resistance in nondiabetic and diabetic individuals and modification by sex
Haider, N., Lebastchi, J., Jayavelu, A. K., Batista, T. M., Pan, H., Dreyfuss, J. M., Carcamo-Orive, I., Knowles, J. W., Mann, Matthias & Kahn, C. R., 1 Nov 2021, In: The Journal of Clinical Investigation. 131, 21Research output: Contribution to journal › Journal article › Research › peer-review
Phosphoproteome profiling uncovers a key role for CDKs in TNF signaling
Tanzer, M. C., Bludau, I., Stafford, C. A., Hornung, V. & Mann, Matthias, 18 Oct 2021, In: Nature Communications. 12, 1, p. 6053Research output: Contribution to journal › Journal article › Research › peer-review
Defining the RBPome of primary T helper cells to elucidate higher-order Roquin-mediated mRNA regulation
Hoefig, K. P., Reim, A., Gallus, C., Wong, E. H., Behrens, G., Conrad, C., Xu, M., Kifinger, L., Ito-Kureha, T., Defourny, K. A. Y., Geerlof, A., Mautner, J., Hauck, S. M., Baumjohann, D., Feederle, R., Mann, Matthias, Wierer, M., Glasmacher, E. & Heissmeyer, V., 1 Sep 2021, In: Nature Communications. 12, 1, p. 5208Research output: Contribution to journal › Journal article › Research › peer-review
Artificial intelligence for proteomics and biomarker discovery
Mann, Matthias, Kumar, C., Zeng, W. & Strauss, M. T., 18 Aug 2021, In: Cell Systems. 12, 8, p. 759-770 12 p.Research output: Contribution to journal › Review › Research › peer-review
Trapped Ion Mobility Spectrometry (TIMS) and Parallel Accumulation - Serial Fragmentation (PASEF) in Proteomics
Meier, F., Park, M. A. & Mann, Matthias, 17 Aug 2021, (E-pub ahead of print) In: Molecular and Cellular Proteomics. p. 100138Research output: Contribution to journal › Journal article › Research › peer-review
Identification of the transcription factor MAZ as a regulator of erythropoiesis
Deen, D., Butter, F., Daniels, D. E., Ferrer-Vicens, I., Ferguson, D. C. J., Holland, M. L., Samara, V., Sloane-Stanley, J. A., Ayyub, H., Mann, Matthias, Frayne, J., Garrick, D. & Vernimmen, D., 10 Aug 2021, In: Blood advances. 5, 15, p. 3002-3015 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
Identification of covalent modifications regulating immune signaling complex composition and phenotype
Frauenstein, A., Ebner, S., Hansen, F. M., Sinha, A., Phulphagar, K., Swatek, K., Hornburg, D., Mann, Matthias & Meissner, F., Jul 2021, In: Molecular Systems Biology. 17, 7, p. e10125Research output: Contribution to journal › Journal article › Research › peer-review
Multi-omics profiling of living human pancreatic islet donors reveals heterogeneous beta cell trajectories towards type 2 diabetes
Wigger, L., Barovic, M., Brunner, A-D., Marzetta, F., Schöniger, E., Mehl, F., Kipke, N., Friedland, D., Burdet, F., Kessler, C., Lesche, M., Thorens, B., Bonifacio, E., Legido-Quigley, C., Barbier Saint Hilaire, P., Delerive, P., Dahl, A., Klose, C., Gerl, M. J., Simons, K. & 7 others, , 28 Jun 2021, (E-pub ahead of print) In: Nature Metabolism.Research output: Contribution to journal › Journal article › Research › peer-review
GID E3 ligase supramolecular chelate assembly configures multipronged ubiquitin targeting of an oligomeric metabolic enzyme
Sherpa, D., Chrustowicz, J., Qiao, S., Langlois, C. R., Hehl, L. A., Gottemukkala, K. V., Hansen, F. M., Karayel, O., von Gronau, S., Prabu, J. R., Mann, Matthias, Alpi, A. F. & Schulman, B. A., 22 Apr 2021, (E-pub ahead of print) In: Molecular Cell.Research output: Contribution to journal › Journal article › Research › peer-review
Tissue-specific modulation of gene expression in response to lowered insulin signalling in Drosophila
Tain, L. S., Sehlke, R., Meilenbrock, R. L., Leech, T., Paulitz, J., Chokkalingam, M., Nagaraj, N., Grönke, S., Fröhlich, J., Atanassov, I., Mann, Matthias, Beyer, A. & Partridge, L., 21 Apr 2021, In: eLife. 10Research output: Contribution to journal › Journal article › Research › peer-review
Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV
Stukalov, A., Girault, V., Grass, V., Karayel, O., Bergant, V., Urban, C., Haas, D. A., Huang, Y., Oubraham, L., Wang, A., Hamad, M. S., Piras, A., Hansen, F. M., Tanzer, M. C., Paron, I., Zinzula, L., Engleitner, T., Reinecke, M., Lavacca, T. M., Ehmann, R. & 10 others, , 12 Apr 2021, (E-pub ahead of print) In: Nature.Research output: Contribution to journal › Journal article › Research › peer-review
A proteomic atlas of the neointima identifies novel druggable targets for preventive therapy
Wierer, M., Werner, J., Wobst, J., Kastrati, A., Cepele, G., Aherrahrou, R., Sager, H. B., Erdmann, J., Dichgans, M., Flockerzi, V., Civelek, M., Dietrich, A., Mann, Matthias, Schunkert, H. & Kessler, T., 8 Apr 2021, (E-pub ahead of print) In: European Heart Journal.Research output: Contribution to journal › Journal article › Research › peer-review
The tumor suppressor kinase DAPK3 drives tumor-intrinsic immunity through the STING-IFN-β pathway
Takahashi, M., Lio, C. J., Campeau, A., Steger, M., Ay, F., Mann, Matthias, Gonzalez, D. J., Jain, M. & Sharma, S., Apr 2021, In: Nature Immunology. 22, 4, p. 485-496 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
Linkage-specific ubiquitin chain formation depends on a lysine hydrocarbon ruler
Liwocha, J., Krist, D. T., van der Heden van Noort, G. J., Hansen, F. M., Truong, V. H., Karayel, O., Purser, N., Houston, D., Burton, N., Bostock, M. J., Sattler, M., Mann, Matthias, Harrison, J. S., Kleiger, G., Ovaa, H. & Schulman, B. A., Mar 2021, In: Nature Chemical Biology. 17, 3, p. 272-279 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
JAZF1, A Novel p400/TIP60/NuA4 Complex Member, Regulates H2A.Z Acetylation at Regulatory Regions
Procida, T., Friedrich, T., Jack, A. P. M., Peritore, M., Bönisch, C., Eberl, H. C., Daus, N., Kletenkov, K., Nist, A., Stiewe, T., Borggrefe, T., Mann, Matthias, Bartkuhn, M. & Hake, S. B., 12 Jan 2021, In: International Journal of Molecular Sciences. 22, 2Research output: Contribution to journal › Journal article › Research › peer-review
Data-independent acquisition method for ubiquitinome analysis reveals regulation of circadian biology
Hansen, F. M., Tanzer, M. C., Brüning, F., Bludau, I., Stafford, C., Schulman, B. A., Robles, M. S., Karayel, O. & Mann, Matthias, 11 Jan 2021, In: Nature Communications. 12, 1, p. 254Research output: Contribution to journal › Journal article › Research › peer-review
The Hippo pathway controls myofibril assembly and muscle fiber growth by regulating sarcomeric gene expression
Kaya-Çopur, A., Marchiano, F., Hein, M. Y., Alpern, D., Russeil, J., Luis, N. M., Mann, Matthias, Deplancke, B., Habermann, B. H. & Schnorrer, F., 6 Jan 2021, In: eLife. 10Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A new parallel high-pressure packing system enables rapid multiplexed production of capillary columns
Müller-Reif, J. B., Hansen, F. M., Schweizer, L., Treit, P. V., Geyer, P. E. & Mann, Matthias, 2021, In: Molecular and Cellular Proteomics. 20, 10 p., 100082.Research output: Contribution to journal › Journal article › Research › peer-review
AlphaTims: Indexing Trapped Ion Mobility Spectrometry-TOF Data for Fast and Easy Accession and Visualization
Willems, S., Voytik, E., Skowronek, P., Strauss, Maximilian & Mann, Matthias, 2021, In: Molecular and Cellular Proteomics. 20, p. 100149Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cohort profile: the MUNICH Preterm and Term Clinical study (MUNICH-PreTCl), a neonatal birth cohort with focus on prenatal and postnatal determinants of infant and childhood morbidity
Pangratz-Fuehrer, S., Genzel-Boroviczény, O., Bodensohn, W. E., Eisenburger, R., Scharpenack, J., Geyer, P. E., Müller-Reif, J. B., van Hagen, N., Müller, A. M., Jensen, Majken Karoline, Klein, C., Mann, Matthias & Nussbaum, C., 2021, In: BMJ Open. 11, 6, 13 p., e050652.Research output: Contribution to journal › Journal article › Research › peer-review
Deep learning the collisional cross sections of the peptide universe from a million experimental values
Meier, F., Köhler, N. D., Brunner, A. D., Wanka, J. M. H., Voytik, E., Strauss, M. T., Theis, F. J. & Mann, Matthias, 2021, In: Nature Communications. 12, 12 p., 1185.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Deep muscle-proteomic analysis of freeze-dried human muscle biopsies reveals fiber type-specific adaptations to exercise training
Deshmukh, Atul Shahaji, Steenberg, D. E., Hostrup, Morten, Birk, Jesper Bratz, Larsen, Jeppe Kjærgaard, Santos, A., Kjøbsted, Rasmus, Hingst, J. R., Schéele, Camilla Charlotte Nielsen, Murgia, M., Kiens, Bente, Richter, Erik A., Mann, Matthias & Wojtaszewski, Jørgen F P, 2021, In: Nature Communications. 12, 15 p., 304.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Defining NASH from a multi-omics systems biology perspective
Niu, Lili, Sulek, K., Vasilopoulou, C. G., Santos, A., Albrechtsen, Nicolai Jacob Wewer, Rasmussen, Simon, Meier, F. & Mann, Matthias, 2021, In: Journal of Clinical Medicine. 10, 20, 22 p., 4673.Research output: Contribution to journal › Review › Research › peer-review
- Published
Distinct signaling by insulin and IGF-1 receptors and their extra- and intracellular domains
Nagao, H., Cai, W., Albrechtsen, Nicolai Jacob Wewer, Steger, M., Batista, T. M., Pan, H., Dreyfuss, J. M., Mann, Matthias & Kahn, C. R., 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 17, e2019474118.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ethical Principles, Constraints and Opportunities in Clinical Proteomics
Porsdam Mann, Sebastian, Treit, P. V., Geyer, P. E., Omenn, G. S. & Mann, Matthias, 2021, In: Molecular and Cellular Proteomics. 20, 14 p., 100046.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hepatocyte-specific perturbation of NAD+ biosynthetic pathways in mice induces reversible nonalcoholic steatohepatitis-like phenotypes
Dall, M., Hassing, Anna Skab, Niu, Lili, Nielsen, Thomas Svava, Ingerslev, L. R., Sulek, K., Trammell, Sam, Gillum, M. P., Barrès, Romain, Larsen, Steen, Poulsen, Steen Seier, Mann, Matthias, Ørskov, Cathrine & Treebak, Jonas Thue, 2021, In: Journal of Biological Chemistry. 297, 6, 26 p., 101388.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
High-resolution serum proteome trajectories in COVID-19 reveal patient-specific seroconversion
Geyer, P. E., Arend, F. M., Doll, S., Louiset, M., Virreira Winter, S., Müller-Reif, J. B., Torun, F. M., Weigand, M., Eichhorn, P., Bruegel, M., Strauss, M. T., Holdt, L. M., Mann, Matthias & Teupser, D., 2021, In: EMBO Molecular Medicine. 13, 8, 16 p., e14167.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hippocampal disruptions of synaptic and astrocyte metabolism are primary events of early amyloid pathology in the 5xFAD mouse model of Alzheimer's disease
Andersen, Jens Velde, Skotte, Niels Henning, Christensen, S. K., Polli, F. S., Shabani, M., Markussen, K. H., Haukedal, H., Westi, Emil Winther, Diaz-delCastillo, M., Sun, R. C., Kohlmeier, Kristi Anne, Schousboe, Arne, Gentry, M. S., Tanila, H., Freude, Kristine, Aldana, Blanca, Mann, Matthias & Waagepetersen, Helle S., 2021, In: Cell Death & Disease. 12, 11, 13 p., 954 .Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Homology-directed repair protects the replicating genome from metabolic assaults
Somyajit, K., Spies, J., Coscia, F., Kirik, U., Rask, M., Lee, J., Neelsen, K. J., Mund, Andreas, Jensen, Lars Juhl, Paull, T. T., Mann, Matthias & Lukas, Jiri, 2021, In: Developmental Cell. 56, 4, p. 461-477.e7Research output: Contribution to journal › Journal article › Research › peer-review
Integrative analysis of cell state changes in lung fibrosis with peripheral protein biomarkers
Mayr, C. H., Simon, L. M., Leuschner, G., Ansari, M., Schniering, J., Geyer, P. E., Angelidis, I., Strunz, M., Singh, P., Kneidinger, N., Reichenberger, F., Silbernagel, E., Böhm, S., Adler, H., Lindner, M., Maurer, B., Hilgendorff, A., Prasse, A., Behr, J., Mann, M. & 3 others, , 2021, In: EMBO Molecular Medicine. e12871.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Interaction of 7SK with the Smn complex modulates snRNP production
Ji, C., Bader, J., Ramanathan, P., Hennlein, L., Meissner, F., Jablonka, S., Mann, Matthias, Fischer, U., Sendtner, M. & Briese, M., 2021, In: Nature Communications. 12, 1, 15 p., 1278.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Large scale discovery of coronavirus-host factor protein interaction motifs reveals SARS-CoV-2 specific mechanisms and vulnerabilities
Kruse, T., Benz, C., Garvanska, D. H., Lindqvist, R., Mihalic, F., Coscia, F., Inturi, R., Sayadi, A., Simonetti, L., Nilsson, E., Ali, M., Kliche, J., Moliner Morro, A., Mund, A., Andersson, E., McInerney, G., Mann, M., Jemth, P., Davey, N. E., Överby, A. K. & 2 others, , 2021, In: Nature Communications. 12, 1, 13 p., 6761.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Loss of full-length hnRNP R isoform impairs DNA damage response in motoneurons by inhibiting Yb1 recruitment to chromatin
Ghanawi, H., Hennlein, L., Zare, A., Bader, J., Salehi, S., Hornburg, D., Ji, C., Sivadasan, R., Drepper, C., Meissner, F., Mann, Matthias, Jablonka, S., Briese, M. & Sendtner, M., 2021, In: Nucleic Acids Symposium Series. 49, 21, p. 12284-12305 22 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular Origin of Blood-based Infrared Spectroscopic Fingerprints
Voronina, L., Leonardo, C., Mueller-Reif, J. B., Geyer, P. E., Huber, M., Trubetskov, M., Kepesidis, K. V., Behr, J., Mann, Matthias, Krausz, F. & Žigman, M., 2021, In: Angewandte Chemie International Edition. 60, 31, p. 17060-17069Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular response to PARP1 inhibition in ovarian cancer cells as determined by mass spectrometry based proteomics
Franz, A., Coscia, F., Shen, C., Charaoui, L., Mann, Matthias & Sander, C., 2021, In: Journal of Ovarian Research. 14, 14 p., 140.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 5650809
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Activation of the ATR kinase by the RPA-binding protein ETAA1
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Region and cell-type resolved quantitative proteomic map of the human heart
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Revisiting biomarker discovery by plasma proteomics
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