Guillermo Montoya

Guillermo Montoya

Professor, head of research, Professor


  1. 2024
  2. Published

    VCF1 is a p97/VCP cofactor promoting recognition of ubiquitylated p97-UFD1-NPL4 substrates

    Mirsanaye, Ann Schirin, Hoffmann, Saskia, Weisser, Melanie, Mund, Andreas, Lopez Mendez, B., Typas, D., van den Boom, J., Benedict, Bente, Hendriks, Ivo Alexander, Nielsen, Michael Lund, Meyer, H., Duxin, Julien, Montoya, Guillermo & Mailand, Niels, 2024, In: Nature Communications. 15, 1, 16 p., 2459.

    Research output: Contribution to journalJournal articlepeer-review

  3. 2023
  4. Published

    DAXX adds a de novo H3.3K9me3 deposition pathway to the histone chaperone network

    Carraro, Massimo, Hendriks, Ivo Alexander, Hammond, Colin, Solis-Mezarino, V., Völker-Albert, M., Elsborg, Jonas Damgaard, Weisser, Melanie, Spanos, C., Montoya, Guillermo, Rappsilber, J., Imhof, A., Nielsen, Michael Lund & Groth, Anja, 2023, In: Molecular Cell. 83, 7, p. 1075-1092.e9 28 p.

    Research output: Contribution to journalJournal articlepeer-review

  5. Published
  6. Published

    TnpB structure reveals minimal functional core of Cas12 nuclease family

    Sasnauskas, G., Tamulaitiene, G., Druteika, G., Carabias del Rey, Arturo, Silanskas, A., Kazlauskas, D., Venclovas, Č., Montoya, Guillermo, Karvelis, T. & Siksnys, V., 2023, In: Nature. 616, 7956, p. 384-389 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  7. Published

    Transposons and CRISPR: Rewiring Gene Editing

    Tenjo Castano, Francisco Javier, Montoya, Guillermo & Carabias del Rey, Arturo, 2023, In: Biochemistry. 62, 24, p. 3521-3532 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  8. 2022
  9. Published

    Chemogenetic profiling reveals PP2A-independent cytotoxicity of proposed PP2A activators iHAP1 and DT-061

    Vit, G., Duro, Joana Maria, Rajendraprasad, G., Hertz, Emil Peter Thrane, Holland, L. K. K., Weisser, Melanie, McEwan, B. C., Lopez-Mendez, B., Sotelo-Parrilla, P., Jeyaprakash, A. A., Montoya, Guillermo, Mailand, Niels, Maeda, K., Kettenbach, A., Barisic, Marin & Nilsson, Jakob, 2022, In: EMBO Journal. 41, 14, e110611.

    Research output: Contribution to journalJournal articlepeer-review

  10. Published

    Evolutionary origin of vertebrate OCT4/POU5 functions in supporting pluripotency

    Sukparangsi, W., Morganti, E., Lowndes, Molly, Mayeur, H., Weisser, Melanie, Hammachi, F., Peradziryi, H., Roske, F., Hölzenspies, J., Livigni, A., Godard, B. G., Sugahara, F., Kuratani, S., Montoya, Guillermo, Frankenberg, S. R., Mazan, S. & Brickman, Joshua Mark, 2022, In: Nature Communications. 13, 1, 21 p., 5537.

    Research output: Contribution to journalJournal articlepeer-review

  11. Published

    Identification and Optimization of Novel Small-Molecule Cas9 Inhibitors by Cell-Based High-Throughput Screening

    Lee, S., Tran, K. T., Vazquez-Uribe, R., Gotfredsen, C. H., Clausen, M. H., Mendez, B. L., Montoya, Guillermo, Bach, Anders & Sommer, M. O. A., 2022, In: Journal of Medicinal Chemistry. 65, 4, p. 3266–3305

    Research output: Contribution to journalJournal articlepeer-review

  12. Published

    Mechanics of CRISPR-Cas12a and engineered variants on λ-DNA

    Paul, B., Chaubet, L., Verver, D. E. & Montoya, Guillermo, 2022, In: Nucleic Acids Symposium Series. 50, 9, p. 5208-5225 18 p.

    Research output: Contribution to journalJournal articlepeer-review

  13. Published

    Molecular basis of cyclic tetra-oligoadenylate processing by small standalone CRISPR-Cas ring nucleases

    Molina, R., García Martín, Ricardo, López-Méndez, B., Jensen, A. L. G., Ciges Tomas, Jose Rafael, Marchena-Hurtado, J., Stella, S. & Montoya, Guillermo, 2022, In: Nucleic Acids Research. 50, 19, p. 11199-11213 15 p.

    Research output: Contribution to journalJournal articlepeer-review

  14. Published

    Structure of the RAF1-HSP90-CDC37 complex reveals the basis of RAF1 regulation

    García-Alonso, S., Mesa, Pablo, Ovejero, L. D. L. P., Aizpurua, G., Lechuga, C. G., Zarzuela, E., Santiveri, C. M., Sanclemente, M., Muñoz, J., Musteanu, M., Campos-Olivas, R., Martínez-Torrecuadrada, J., Barbacid, M. & Montoya, Guillermo, 2022, In: Molecular Cell. 82, 18, p. 3438-3452.e8

    Research output: Contribution to journalJournal articlepeer-review

  15. Published

    Structure of the TnsB transposase-DNA complex of type V-K CRISPR-associated transposon

    Tenjo Castano, Francisco Javier, Sofos, N., López-Méndez, B., Stutzke, L. S., Fuglsang, Anders, Stella, S. & Montoya, Guillermo, 2022, In: Nature Communications. 13, 14 p., 5792.

    Research output: Contribution to journalJournal articlepeer-review

  16. 2021
  17. Published

    A highly conserved pocket on PP2A-B56 is required for hSgo1 binding and cohesion protection during mitosis

    Ueki, Y., Hadders, M. A., Weisser, Melanie, Nasa, I., Sotelo-Parrilla, P., Cressey, L. E., Gupta, T., Hertz, Emil Peter Thrane, Kruse, Thomas, Montoya, Guillermo, Jeyaprakash, A. A., Kettenbach, A., Lens, S. M. A. & Nilsson, Jakob, 2021, In: EMBO Reports. 22, 7, 13 p., e52295.

    Research output: Contribution to journalJournal articlepeer-review

  18. Published

    Structural basis of cyclic oligoadenylate degradation by ancillary Type III CRISPR-Cas ring nucleases

    Molina Monterrubio, R. A., Jensen, A. L. G., Marchena-Hurtado, J., López-Méndez, B., Stella, S. & Montoya, Guillermo, 2021, In: Nucleic Acids Research. 49, 21, p. 12577-12590 14 p.

    Research output: Contribution to journalJournal articlepeer-review

  19. Published

    Structure of the mini-RNA-guided endonuclease CRISPR-Cas12j3

    Carabias del Rey, Arturo, Fuglsang, Anders, Temperini, Piero, Pape, T., Sofos, N., Stella, S., Erlendsson, Simon & Montoya, Guillermo, 2021, In: Nature Communications. 12, 12 p., 4476.

    Research output: Contribution to journalJournal articlepeer-review

  20. 2020
  21. Published

    DeepFRET, a software for rapid and automated single-molecule FRET data classification using deep learning

    Thomsen, J., Sletfjerding, M. B., Jensen, S. B., Stella, S., Paul, B., Malle, M. G., Montoya, Guillermo, Petersen, Troels Christian & Hatzakis, Nikos, Nov 2020, In: eLife. 9, 21 p., e60404.

    Research output: Contribution to journalJournal articlepeer-review

  22. Published

    Direct Observation of CRISPR-Cas12 Conformational Sampling by SM FRET and Cryo EM Reveals how Conformational Activation Promotes Catalysis and Resetting of the Endonuclease Activity

    Stella, S., Mesa, Pablo, Thomsen, J., Paul, B., Alcon, P., Jensen, S. B., Moses, M. E., Montoya, Guillermo & Hatzakis, Nikos, 7 Feb 2020, In: Biophysical Journal. 118, 3, p. 223A-224A 2 p.

    Research output: Contribution to journalConference abstract in journal

  23. Published

    CRISPR-Cas12a: functional overview and applications

    Paul, B. & Montoya, Guillermo, 2020, In: Biomedical Journal. 43, 1, p. 8-17

    Research output: Contribution to journalReviewpeer-review

  24. Published

    Editorial overview: Protein-nucleic acid interactions: 'Takes two to Tango'

    Montoya, Guillermo & Carlomagno, T., 2020, In: Current Opinion in Structural Biology. 65, p. v-vi 2 p.

    Research output: Contribution to journalEditorial

  25. Published

    Molecular Basis of the Mechanisms Controlling MASTL

    Hermida, D., Mortuza, G. B., Pedersen, Anna-Kathrine, Pozdnyakova, I., Nguyen, T. T. T. N., Maroto, M., Williamson, M., Ebersole, T., Cazzamali, G., Rand, Kasper Dyrberg, Olsen, Jesper Velgaard, Malumbres, M. & Montoya, Guillermo, 2020, In: Molecular & Cellular Proteomics. 19, 2, p. 326-343

    Research output: Contribution to journalJournal articlepeer-review

  26. Published

    Structural basis of CRISPR-Cas Type III prokaryotic defence systems

    Molina, R., Sofos, N. & Montoya, Guillermo, 2020, In: Current Opinion in Structural Biology. 65, p. 119-129 11 p.

    Research output: Contribution to journalReviewpeer-review

  27. Published

    Structures of the Cmr-β Complex Reveal the Regulation of the Immunity Mechanism of Type III-B CRISPR-Cas

    Sofos, N., Feng, M., Stella, S., Pape, T., Fuglsang, Anders, Lin, Jinzhong, Huang, Q., Li, Y., She, Q. & Montoya, Guillermo, 2020, In: Molecular Cell. 79, 5, p. 741-757

    Research output: Contribution to journalJournal articlepeer-review

  28. Published

    The TRiC/CCT Chaperonin and Its Role in Uncontrolled Proliferation

    Wang, D. Y., Kamuda, K., Montoya, Guillermo & Mesa, Pablo, 2020, HSF1 and Molecular Chaperones in Biology and Cancer. Mendillo, M. L., Pincus, D. & ScherzShouval, R. (eds.). Springer, p. 21-40 20 p. (Advances in Experimental Medicine and Biology, Vol. 1243).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  29. 2019
  30. Published

    A Consensus Binding Motif for the PP4 Protein Phosphatase

    Ueki, Y., Kruse, Thomas, Weisser, Melanie, Sundell, G. N., Larsen, Marie Sofie Yoo, Mendez, B. L., Jenkins, N. P., Garvanska, Dimitriya Hristoforova, Cressey, L., Zhang, G., Davey, N., Montoya, Guillermo, Ivarsson, Y., Kettenbach, A. N. & Nilsson, Jakob, 2019, In: Molecular Cell. 76, 6, p. 953-964.e6

    Research output: Contribution to journalJournal articlepeer-review

  31. Published

    High-Resolution Structure of Cas13b and Biochemical Characterization of RNA Targeting and Cleavage

    Slaymaker, I. M., Mesa, Pablo, Kellner, M. J., Kannan, S., Brignole, E., Koob, J., Feliciano, P. R., Stella, S., Abudayyeh, O. O., Gootenberg, J. S., Strecker, J., Montoya, Guillermo & Zhang, F., 2019, In: Cell Reports. 26, 13, p. 3741-3751.e5 17 p.

    Research output: Contribution to journalJournal articlepeer-review

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ID: 93716435