Guillermo Montoya

Guillermo Montoya

Professor, head of research, Professor


  1. Published

    Structure and dynamics of mesophilic variants from the homing endonuclease I-DmoI

    Alba, J., Marcaida, M. J., Prieto, J., Montoya, Guillermo, Molina, R. & D'Abramo, M., Dec 2017, In: Journal of Computer - Aided Molecular Design. 31, 12, p. 1063-1072 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  2. Published

    Assembly of Francisella novicida Cpf1 endonuclease in complex with guide RNA and target DNA

    Alcón, P., Montoya, Guillermo & Stella, S., 1 Jul 2017, In: Acta Crystallographica Section F: Structural Biology Communications. 73, Pt 7, p. 409-415 7 p.

    Research output: Contribution to journalJournal articlepeer-review

  3. Published

    Electron Microscopy Structural Insights into CPAP Oligomeric Behavior: A Plausible Assembly Process of a Supramolecular Scaffold of the Centrosome

    Alvarez-Cabrera, A. L., Delgado, S., Gil-Carton, D., Mortuza, G. B., Montoya, Guillermo, Sorzano, C. O. S., Tang, T. K. & Carazo, J. M., 2017, In: Frontiers in Molecular Biosciences. 4, 14 p., 17.

    Research output: Contribution to journalJournal articlepeer-review

  4. Published

    Molecular architecture of the recombinant human MCM2-7 helicase in complex with nucleotides and DNA

    Boskovic, J., Bragado-Nilsson, E., Saligram Prabhakar, B., Yefimenko, I., Martínez-Gago, J., Muñoz, S., Méndez, J. & Montoya, Guillermo, 16 Sep 2016, In: Cell Cycle. 15, 18, p. 2431-40 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  5. Published

    Structure of the mini-RNA-guided endonuclease CRISPR-Cas12j3

    Carabias del Rey, Arturo, Fuglsang, Anders, Temperini, Piero, Pape, T., Sofos, N., Stella, S., Erlendsson, Simon & Montoya, Guillermo, 2021, In: Nature Communications. 12, 12 p., 4476.

    Research output: Contribution to journalJournal articlepeer-review

  6. Published

    DAXX adds a de novo H3.3K9me3 deposition pathway to the histone chaperone network

    Carraro, Massimo, Hendriks, Ivo Alexander, Hammond, Colin, Solis-Mezarino, V., Völker-Albert, M., Elsborg, Jonas Damgaard, Weisser, Melanie, Spanos, C., Montoya, Guillermo, Rappsilber, J., Imhof, A., Nielsen, Michael Lund & Groth, Anja, 2023, In: Molecular Cell. 83, 7, p. 1075-1092.e9 28 p.

    Research output: Contribution to journalJournal articlepeer-review

  7. Published

    Functional and in silico assessment of MAX variants of unknown significance

    Comino-Méndez, I., Leandro-García, L. J., Montoya, G., Inglada-Pérez, L., de Cubas, A. A., Currás-Freixes, M., Tysoe, C., Izatt, L., Letón, R., Gómez-Graña, Á., Mancikova, V., Apellániz-Ruiz, M., Mannelli, M., Schiavi, F., Favier, J., Gimenez-Roqueplo, A-P., Timmers, H. J. L. M., Roncador, G., Garcia, J. F., Rodríguez-Antona, C. & 2 others, Robledo, M. & Cascón, A., Nov 2015, In: Journal of Molecular Medicine. 93, 11, p. 1247-55 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  8. Published

    Structure of p15PAF-PCNA complex and implications for clamp sliding during DNA replication and repair

    De Biasio, A., de Opakua, A. I., Mortuza, G. B., Molina, R., Cordeiro, T. N., Castillo, F., Villate, M., Merino, N., Delgado, S., Gil-Cartón, D., Luque, I., Diercks, T., Bernadó, P., Montoya, Guillermo & Blanco, F. J., 12 Mar 2015, In: Nature Communications. 6, p. 1-12 6439.

    Research output: Contribution to journalJournal articlepeer-review

  9. Published

    Molecular architecture of the Jumonji C family histone demethylase KDM5B

    Dorosz, J., Kristensen, L. H., Aduri, N. G., Mirza, Osman Asghar, Lousen, R., Bucciarelli, S., Mehta, V., Sellés Baiget, Selene, Solbak, Sara Marie Øie, Bach, Anders, Mesa, Pablo, Hernandez, P. A., Montoya, Guillermo, Nguyen, T. T. T. N., Rand, Kasper Dyrberg, Boesen, T. & Gajhede, Michael, 2019, In: Scientific Reports. 9, 13 p., 4019.

    Research output: Contribution to journalJournal articlepeer-review

  10. Published

    Structure of the RAF1-HSP90-CDC37 complex reveals the basis of RAF1 regulation

    García-Alonso, S., Mesa, Pablo, Ovejero, L. D. L. P., Aizpurua, G., Lechuga, C. G., Zarzuela, E., Santiveri, C. M., Sanclemente, M., Muñoz, J., Musteanu, M., Campos-Olivas, R., Martínez-Torrecuadrada, J., Barbacid, M. & Montoya, Guillermo, 2022, In: Molecular Cell. 82, 18, p. 3438-3452.e8

    Research output: Contribution to journalJournal articlepeer-review

  11. Published

    A Type III-B Cmr effector complex catalyzes the synthesis of cyclic oligoadenylate second messengers by cooperative substrate binding

    Han, W., Stella, S., Zhang, Y., Guo, T., Sulek, K., Peng-Lundgren, L., Montoya, Guillermo & She, Q., 2018, In: Nucleic Acids Research. 46, 19, p. 10319-10330 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  12. Published

    Allosteric regulation of Csx1, a type IIIB-associated CARF domain ribonuclease by RNAs carrying a tetraadenylate tail

    Han, W., Pan, S., López-Méndez, B., Montoya, Guillermo & She, Q., 13 Oct 2017, In: Nucleic Acids Research. 45, 18, p. 10740-10750 11 p., gkx726.

    Research output: Contribution to journalJournal articlepeer-review

  13. Published

    Molecular Basis of the Mechanisms Controlling MASTL

    Hermida, D., Mortuza, G. B., Pedersen, Anna-Kathrine, Pozdnyakova, I., Nguyen, T. T. T. N., Maroto, M., Williamson, M., Ebersole, T., Cazzamali, G., Rand, Kasper Dyrberg, Olsen, Jesper Velgaard, Malumbres, M. & Montoya, Guillermo, 2020, In: Molecular & Cellular Proteomics. 19, 2, p. 326-343

    Research output: Contribution to journalJournal articlepeer-review

  14. Published

    A Conserved Motif Provides Binding Specificity to the PP2A-B56 Phosphatase

    Hertz, Emil Peter Thrane, Kruse, Thomas, Davey, N. E., López-Méndez, B., Sigurdsson, J. O., Montoya, Guillermo, Olsen, Jesper Velgaard & Nilsson, Jakob, 2016, In: Molecular Cell. 63, 4, p. 686-695 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  15. Published

    TRAIP is a PCNA-binding ubiquitin ligase that protects genome stability after replication stress

    Hoffmann, Saskia, Smedegaard, S., Nakamura, K., Mortuza, G. B., Räschle, M., Ibañez de Opakua, A., Oka, Y., Feng, Y., Blanco, F. J., Mann, Matthias, Montoya, Guillermo, Groth, Anja, Bekker-Jensen, Simon Holst & Mailand, Niels, 4 Jan 2016, In: The Journal of Cell Biology. 212, 1, p. 63-75

    Research output: Contribution to journalJournal articlepeer-review

  16. Published

    Comprehensive analysis of the specificity of transcription activator-like effector nucleases

    Juillerat, A., Dubois, G., Valton, J., Thomas, S., Stella, S., Maréchal, A., Langevin, S., Benomari, N., Bertonati, C., Silva, G. H., Daboussi, F., Epinat, J., Montoya, Guillermo, Duclert, A. & Duchateau, P., Apr 2014, In: Nucleic Acids Research. 42, 8, p. 5390-402 13 p.

    Research output: Contribution to journalJournal articlepeer-review

  17. Published
  18. Published

    Identification and Optimization of Novel Small-Molecule Cas9 Inhibitors by Cell-Based High-Throughput Screening

    Lee, S., Tran, K. T., Vazquez-Uribe, R., Gotfredsen, C. H., Clausen, M. H., Mendez, B. L., Montoya, Guillermo, Bach, Anders & Sommer, M. O. A., 2022, In: Journal of Medicinal Chemistry. 65, 4, p. 3266–3305

    Research output: Contribution to journalJournal articlepeer-review

  19. Published

    Oncogenic Mutations Rewire Signaling Pathways by Switching Protein Recruitment to Phosphotyrosine Sites

    Lundby, Alicia, Franciosa, Giulia, Emdal, Kristina Bennet, Refsgaard, J. C., Gnosa, S. P., Bekker-Jensen, D. B., Secher, A., Maurya, S. R., Paul, I., Mendez, B. L., Kelstrup, C. D., Francavilla, C., Kveiborg, Marie, Montoya, Guillermo, Jensen, Lars Juhl & Olsen, Jesper Velgaard, 2019, In: Cell. 179, 2, p. 543-560

    Research output: Contribution to journalJournal articlepeer-review

  20. Directly from the source: endogenous preparations of molecular machines

    Mesa, Pablo, Deniaud, A., Montoya, Guillermo & Schaffitzel, C., Jun 2013, In: Current Opinion in Structural Biology. 23, 3, p. 319-25 7 p.

    Research output: Contribution to journalReviewpeer-review

  21. Published

    VCF1 is a p97/VCP cofactor promoting recognition of ubiquitylated p97-UFD1-NPL4 substrates

    Mirsanaye, Ann Schirin, Hoffmann, Saskia, Weisser, Melanie, Mund, Andreas, Lopez Mendez, B., Typas, D., van den Boom, J., Benedict, Bente, Hendriks, Ivo Alexander, Nielsen, Michael Lund, Meyer, H., Duxin, Julien, Montoya, Guillermo & Mailand, Niels, 2024, In: Nature Communications. 15, 1, 16 p., 2459.

    Research output: Contribution to journalJournal articlepeer-review

  22. Published

    Structure of Csx1-cOA4 complex reveals the basis of RNA decay in Type III-B CRISPR-Cas

    Molina, R., Stella, S., Feng, M., Sofos, N., Jauniskis, V., Pozdnyakova, I., López-Méndez, B., She, Q. & Montoya, Guillermo, 2019, In: Nature Communications. 10, 14 p., 4302.

    Research output: Contribution to journalJournal articlepeer-review

  23. Published

    Engineering a Nickase on the Homing Endonuclease I-DmoI Scaffold

    Molina, R., Marcaida, M. J., Redondo, P., Marenchino, M., Duchateau, P., D'Abramo, M., Montoya, Guillermo & Prieto, J., 2015, In: The Journal of Biological Chemistry. 290, 30, p. 18534-18544 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  24. Published

    Crystal Structure of the Homing Endonuclease I-CvuI Provides a New Template for Genome Modification

    Molina, R., Redondo, P., López-Méndez, B., Villate, M., Merino, N., Blanco, F. J., Valton, J., Grizot, S., Duchateau, P., Prieto, J. & Montoya, Guillermo, 27 Nov 2015, In: The Journal of Biological Chemistry. 290, 48, p. 28727-36 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  25. Published

    Structural basis of CRISPR-Cas Type III prokaryotic defence systems

    Molina, R., Sofos, N. & Montoya, Guillermo, 2020, In: Current Opinion in Structural Biology. 65, p. 119-129 11 p.

    Research output: Contribution to journalReviewpeer-review

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