Chuna Ram Choudhary

Chuna Ram Choudhary

Professor, Group Leader, Professor

Member of:


    1. 2023
    2. Published

      Acetylation of histone H2B marks active enhancers and predicts CBP/p300 target genes

      Narita, Takeo, Higashijima, Y., Kilic, Sinan, Liebner, Tim, Walter, Jonas & Choudhary, Chunaram, 2023, In: Nature Genetics. 55, p. 679-692

      Research output: Contribution to journalJournal articlepeer-review

    3. Published

      K6-linked ubiquitylation marks formaldehyde-induced RNA-protein crosslinks for resolution

      Suryo Rahmanto, A., Blum, C. J., Scalera, C., Heidelberger, J. B., Mesitov, M., Horn-Ghetko, D., Gräf, J. F., Mikicic, I., Hobrecht, R., Orekhova, A., Ostermaier, M., Ebersberger, S., Möckel, M. M., Krapoth, N., Da Silva Fernandes, N., Mizi, A., Zhu, Y., Chen, J. X., Choudhary, C., Papantonis, A. & 4 others, Ulrich, H. D., Schulman, B. A., König, J. & Beli, P., 2023, In: Molecular Cell. 83, 23, p. 4272-4289.e10 29 p.

      Research output: Contribution to journalJournal articlepeer-review

    4. Published

      TOBF1 modulates mouse embryonic stem cell fate through regulating alternative splicing of pluripotency genes

      Aich, M., Ansari, A. H., Ding, Li, Iesmantavicius, V., Paul, D., Choudhary, Chunaram, Maiti, S., Buchholz, F. & Chakraborty, D., 2023, In: Cell Reports. 42, 10, 22 p., 113177.

      Research output: Contribution to journalJournal articlepeer-review

    5. 2022
    6. Published

      HDAC6 modulates myofibril stiffness and diastolic function of the heart

      Lin, Y., Major, J. L., Liebner, Tim, Hourani, Z., Travers, J. G., Wennersten, S. A., Haefner, K. R., Cavasin, M. A., Wilson, C. E., Jeong, M. Y., Han, Y., Gotthardt, M., Ferguson, S. K., Ambardekar, A. V., Lam, M. P., Choudhary, Chunaram, Granzier, H. L., Woulfe, K. C. & McKinsey, T. A., 2022, In: Journal of Clinical Investigation. 132, 10, 14 p., e148333.

      Research output: Contribution to journalJournal articlepeer-review

    7. 2021
    8. Published

      Enhancers are activated by p300/CBP activity-dependent PIC assembly, RNAPII recruitment, and pause release

      Narita, Takeo, Ito, S., Higashijima, Y., Chu, W. K., Neumann, K., Walter, Jonas, Satpathy, S., Liebner, Tim, Hamilton, W. B., Maskey, E., Prus, G., Shibata, M., Iesmantavicius, V., Brickman, Joshua Mark, Anastassiadis, K., Koseki, H. & Choudhary, Chunaram, 2021, In: Molecular Cell. 81, 10, p. 2166-2182.e6

      Research output: Contribution to journalJournal articlepeer-review

    9. Published

      Proteome dynamics at broken replication forks reveal a distinct ATM-directed repair response suppressing DNA double-strand break ubiquitination

      Nakamura, K., Kustatscher, G., Alabert, C., Hödl, M., Forne, I., Völker-Albert, M., Satpathy, S., Beyer, T. E., Mailand, Niels, Choudhary, Chunaram, Imhof, A., Rappsilber, J. & Groth, Anja, 2021, In: Molecular Cell. 81, 3, 23 p.

      Research output: Contribution to journalJournal articlepeer-review

    10. Published

      SIK2 orchestrates actin-dependent host response upon Salmonella infection

      Hahn, M., Covarrubias-Pinto, A., Herhaus, L., Satpathy, S., Klann, K., Boyle, K. B., Münch, C., Rajalingam, K., Randow, F., Choudhary, Chunaram & Dikic, I., 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 19, 10 p., e2024144118.

      Research output: Contribution to journalJournal articlepeer-review

    11. 2020
    12. Published

      Equilibrium between nascent and parental MCM proteins protects replicating genomes

      Sedlackova, H., Rask, M., Gupta, R., Choudhary, Chunaram, Somyajit, K. & Lukas, Jiri, 2020, In: Nature. 587, p. 297-302 34 p.

      Research output: Contribution to journalJournal articlepeer-review

    13. Published

      HBO1 is required for the maintenance of leukaemia stem cells

      MacPherson, L., Anokye, J., Yeung, M. M., Lam, E. Y. N., Chan, Y-C., Weng, C-F., Yeh, P., Knezevic, K., Butler, M. S., Hoegl, A., Chan, K-L., Burr, M. L., Gearing, L. J., Willson, T., Liu, J., Choi, J., Yang, Y., Bilardi, R. A., Falk, H., Nghi Nguyen & 28 others, Stupple, P. A., Peat, T. S., Zhang, M., De Silva, M., Carrasco-Pozo, C., Avery, V. M., Khoo, S., Dolezal, O., Dennis, M. L., Nuttall, S., Surjadi, R., Newman, J., Ren, B., Leaver, D. J., Sun, Y., Baell, J. B., Dovey, O., Vassiliou, G. S., Grebien, F., Dawson, S., Street, I. P., Monahan, B. J., Burns, C. J., Choudhary, Chunaram, Blewitt, M. E., Voss, A. K., Thomas, T. & Dawson, M. A., 2020, In: Nature. 577, 7789, p. 266-270

      Research output: Contribution to journalJournal articlepeer-review

    14. Published

      Histone Acetyltransferase MOF Blocks Acquisition of Quiescence in Ground-State ESCs through Activating Fatty Acid Oxidation

      Khoa, L. T. P., Tsan, Y., Mao, F., Kremer, D. M., Sajjakulnukit, P., Zhang, L., Zhou, B., Tong, X., Bhanu, N. V., Choudhary, Chunaram, Garcia, B. A., Yin, L., Smith, G. D., Saunders, T. L., Bielas, S. L., Lyssiotis, C. A. & Dou, Y., 2020, In: Cell Stem Cell. 27, 3, p. 441-458.e10 29 p.

      Research output: Contribution to journalJournal articlepeer-review

    15. Published

      Sequencing of the First Draft of the Human Acetylome

      Choudhary, Chunaram & Mann, Matthias, 2020, In: Clinical Chemistry. 66, 6, p. 852-853 2 p.

      Research output: Contribution to journalJournal articlepeer-review

    16. 2019
    17. Published

      Acetylation of intrinsically disordered regions regulates phase separation

      Saito, M., Hess, D., Eglinger, J., Fritsch, A. W., Kreysing, M., Weinert, B. T., Choudhary, Chunaram & Matthias, P., Jan 2019, In: Nature Chemical Biology. 15, 1, p. 51-61

      Research output: Contribution to journalJournal articlepeer-review

    18. Published

      Analysis and Interpretation of Protein Post-Translational Modification Site Stoichiometry

      Prus, Gabriela Zofia, Hoegl, A., Weinert, B. T. & Choudhary, Chunaram, 2019, In: Trends in Biochemical Sciences. 44, 11, p. 943-960

      Research output: Contribution to journalReviewpeer-review

    19. Published

      Analysis of human acetylation stoichiometry defines mechanistic constraints on protein regulation

      Hansen, B. K., Gupta, R., Baldus, L., Lyon, D., Narita, Takeo, Lammers, M., Choudhary, Chunaram & Weinert, B. T., 2019, In: Nature Communications. 10, 11 p., 1055.

      Research output: Contribution to journalJournal articlepeer-review

    20. Published

      Functions and mechanisms of non-histone protein acetylation

      Narita, Takeo, Weinert, B. T. & Choudhary, Chunaram, 2019, In: Nature Reviews. Molecular Cell Biology. 20, p. 156-174 19 p.

      Research output: Contribution to journalReviewpeer-review

    21. Published

      Proteomic exploration of lysine acetylation signaling

      Choudhary, Chunaram, 2019, In: Molecular & Cellular Proteomics. 18, 8, p. S25 1 p.

      Research output: Contribution to journalConference abstract in journal

    22. 2018
    23. Published

      p38-MK2 signaling axis regulates RNA metabolism after UV-light-induced DNA damage

      Borisova, M. E., Voigt, A., Tollenaere, M. A. X., Sahu, S. K., Juretschke, T., Kreim, N., Mailand, Niels, Choudhary, Chunaram, Bekker-Jensen, Simon Holst, Akutsu, M., Wagner, S. A. & Beli, P., 1 Dec 2018, In: Nature Communications. 9, p. 1-16 16 p., 1017.

      Research output: Contribution to journalJournal articlepeer-review

    24. Published

      DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity

      Gupta, R., Somyajit, K., Narita, Takeo, Maskey, E., Stanlie, A., Kremer, M., Typas, D., Lammers, M., Mailand, Niels, Nussenzweig, A., Lukas, Jiri & Choudhary, Chunaram, 2018, In: Cell. 173, 4, p. 972-988

      Research output: Contribution to journalJournal articlepeer-review

    25. Published

      Deletion of APC7 or APC16 Allows Proliferation of Human Cells without the Spindle Assembly Checkpoint

      Wild, T., Budzowska, M., Hellmuth, S., Eibes, S., Karemore, G., Barisic, Marin, Stemmann, O. & Choudhary, Chunaram, 2018, In: Cell Reports. 25, 9, 18 p., 2317-2328.e5.

      Research output: Contribution to journalJournal articlepeer-review

    26. Published

      STK3 is a therapeutic target for a subset of acute myeloid leukemias

      Camgoz, A., Paszkowski-Rogacz, M., Satpathy, S., Wermke, M., Hamann, M. V., von Bonin, M., Choudhary, Chunaram, Knapp, S. & Buchholz, F., 2018, In: OncoTarget. 9, 39, p. 25458-25473 16 p.

      Research output: Contribution to journalJournal articlepeer-review

    27. Published

      Time-Resolved Analysis Reveals Rapid Dynamics and Broad Scope of the CBP/p300 Acetylome

      Weinert, B. T., Narita, Takeo, Satpathy, S., Srinivasan, B., Hansen, B. K., Schölz, C., Hamilton, W. B., Zucconi, B. E., Wang, W. W., Liu, W. R., Brickman, Joshua Mark, Kesicki, E. A., Lai, A., Bromberg, K. D., Cole, P. A. & Choudhary, Chunaram, 2018, In: Cell. 174, 1, p. 231-244.e12 27 p.

      Research output: Contribution to journalJournal articlepeer-review

    28. 2017
    29. Published

      lncRNA Panct1 Maintains Mouse Embryonic Stem Cell Identity by Regulating TOBF1 Recruitment to Oct-Sox Sequences in Early G1

      Chakraborty, D., Paszkowski-Rogacz, M., Berger, N., Ding, L., Mircetic, J., Fu, J., Iesmantavicius, V., Choudhary, Chunaram, Anastassiadis, K., Stewart, A. F. & Buchholz, F., 12 Dec 2017, In: Cell Reports. 21, 11, p. 3012-3021 10 p.

      Research output: Contribution to journalJournal articlepeer-review

    30. Published

      Redox-sensitive alteration of replisome architecture safeguards genome integrity

      Somyajit, K., Gupta, R., Sedlackova, H., Neelsen, K. J., Ochs, Fena, Rask, M., Choudhary, Chunaram & Lukas, Jiri, 10 Nov 2017, In: Science. 358, 6364, p. 797-802 6 p.

      Research output: Contribution to journalJournal articlepeer-review

    31. Published

      Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours

      Lasko, L. M., Jakob, C. G., Edalji, R. P., Qiu, W., Montgomery, D., Digiammarino, E. L., Hansen, T. M., Risi, R. M., Frey, R., Manaves, V., Shaw, B., Algire, M., Hessler, P., Lam, L. T., Uziel, T., Faivre, E., Ferguson, D., Buchanan, F. G., Martin, R. L., Torrent, M. & 16 others, Chiang, G. G., Karukurichi, K., Langston, J. W., Weinert, B. T., Choudhary, Chunaram, de Vries, P., Van Drie, J. H., McElligott, D., Kesicki, E., Marmorstein, R., Sun, C., Cole, P. A., Rosenberg, S. H., Michaelides, M. R., Lai, A. & Bromberg, K. D., 5 Oct 2017, In: Nature. 550, 7674, p. 128-132 5 p.

      Research output: Contribution to journalJournal articlepeer-review

    32. Published

      Accurate quantification of site-specific acetylation stoichiometry reveals the impact of sirtuin deacetylase CobB on the E. coli acetylome

      Weinert, B. T., Satpathy, S., Hansen, B. K., Lyon, D., Jensen, Lars Juhl & Choudhary, Chunaram, May 2017, In: Molecular and Cellular Proteomics. 16, p. 759-769

      Research output: Contribution to journalJournal articlepeer-review

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    ID: 13781159