To spread or not to spread - chromatin modifications in response to DNA damage

Research output: Contribution to journalJournal articleResearchpeer-review

Chromatin modifications in response to DNA damage are vital for genome integrity. Multiple proteins and pathways required to generate specialized chromatin domains around DNA lesions have been identified and the increasing amount of information calls for unifying concepts that would allow us to grasp the ever-increasing complexity. This review aims at contributing to this trend by focusing on feed-forward and feedback mechanisms, which in mammalian cells determine the extent of chromatin modifications after DNA damage. We highlight the emerging notion that the nodal points of these highly dynamic pathways operate in a rate-limiting mode, whose deregulation can disrupt physiological boundaries between damaged and undamaged chromatin, dictate repair pathway choice, and determine the fate of cells exposed to genotoxic stress.
Original languageEnglish
JournalCurrent Opinion in Genetics & Development
Issue number2
Pages (from-to)156-165
Number of pages10
Publication statusPublished - 9 Jan 2013

ID: 46438868