Structural basis for KV7.1/KCNEx interactions in the IKs channel complex

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Structural basis for KV7.1/KCNEx interactions in the IKs channel complex. / Lundby, Alicia; Tseng, Gea-Ny; Schmitt, Nicole.

In: Heart Rhythm, Vol. 7, No. 5, 2010, p. 708-713.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Lundby, A, Tseng, G-N & Schmitt, N 2010, 'Structural basis for KV7.1/KCNEx interactions in the IKs channel complex', Heart Rhythm, vol. 7, no. 5, pp. 708-713. https://doi.org/10.1016/j.hrthm.2009.12.017

APA

Lundby, A., Tseng, G-N., & Schmitt, N. (2010). Structural basis for KV7.1/KCNEx interactions in the IKs channel complex. Heart Rhythm, 7(5), 708-713. https://doi.org/10.1016/j.hrthm.2009.12.017

Vancouver

Lundby A, Tseng G-N, Schmitt N. Structural basis for KV7.1/KCNEx interactions in the IKs channel complex. Heart Rhythm. 2010;7(5):708-713. https://doi.org/10.1016/j.hrthm.2009.12.017

Author

Lundby, Alicia ; Tseng, Gea-Ny ; Schmitt, Nicole. / Structural basis for KV7.1/KCNEx interactions in the IKs channel complex. In: Heart Rhythm. 2010 ; Vol. 7, No. 5. pp. 708-713.

Bibtex

@article{0039f7d035a111df8ed1000ea68e967b,
title = "Structural basis for KV7.1/KCNEx interactions in the IKs channel complex",
abstract = "The cardiac I(Ks) current is involved in action potential repolarization, where its primary function is to limit action potential prolongation during sympathetic stimulation. The I(Ks) channel is mainly composed of K(V)7.1 ion channels associated with KCNE1 auxiliary subunits. The availability of KCNE1 solution structure by NMR spectroscopy in conjunction with biochemical assays addressing K(V)7.1/KCNE1 residue interactions has provided new insights into the structural basis for K(V)7.1 modulation by KCNE1. Recent evidence further suggests that KCNE2 may associate with the K(V)7.1/KCNE1 channel complex and modulate its current amplitude. Here we review recent studies in this area, and discuss potential roles for multiple KCNE(x) subunits in I(Ks) generation and modulation as well as the clinical relevance of the new information.",
author = "Alicia Lundby and Gea-Ny Tseng and Nicole Schmitt",
note = "Copyright {\circledC} 2009. Published by Elsevier Inc.",
year = "2010",
doi = "10.1016/j.hrthm.2009.12.017",
language = "English",
volume = "7",
pages = "708--713",
journal = "Heart Rhythm",
issn = "1547-5271",
publisher = "Elsevier",
number = "5",

}

RIS

TY - JOUR

T1 - Structural basis for KV7.1/KCNEx interactions in the IKs channel complex

AU - Lundby, Alicia

AU - Tseng, Gea-Ny

AU - Schmitt, Nicole

N1 - Copyright © 2009. Published by Elsevier Inc.

PY - 2010

Y1 - 2010

N2 - The cardiac I(Ks) current is involved in action potential repolarization, where its primary function is to limit action potential prolongation during sympathetic stimulation. The I(Ks) channel is mainly composed of K(V)7.1 ion channels associated with KCNE1 auxiliary subunits. The availability of KCNE1 solution structure by NMR spectroscopy in conjunction with biochemical assays addressing K(V)7.1/KCNE1 residue interactions has provided new insights into the structural basis for K(V)7.1 modulation by KCNE1. Recent evidence further suggests that KCNE2 may associate with the K(V)7.1/KCNE1 channel complex and modulate its current amplitude. Here we review recent studies in this area, and discuss potential roles for multiple KCNE(x) subunits in I(Ks) generation and modulation as well as the clinical relevance of the new information.

AB - The cardiac I(Ks) current is involved in action potential repolarization, where its primary function is to limit action potential prolongation during sympathetic stimulation. The I(Ks) channel is mainly composed of K(V)7.1 ion channels associated with KCNE1 auxiliary subunits. The availability of KCNE1 solution structure by NMR spectroscopy in conjunction with biochemical assays addressing K(V)7.1/KCNE1 residue interactions has provided new insights into the structural basis for K(V)7.1 modulation by KCNE1. Recent evidence further suggests that KCNE2 may associate with the K(V)7.1/KCNE1 channel complex and modulate its current amplitude. Here we review recent studies in this area, and discuss potential roles for multiple KCNE(x) subunits in I(Ks) generation and modulation as well as the clinical relevance of the new information.

U2 - 10.1016/j.hrthm.2009.12.017

DO - 10.1016/j.hrthm.2009.12.017

M3 - Journal article

C2 - 20206317

VL - 7

SP - 708

EP - 713

JO - Heart Rhythm

JF - Heart Rhythm

SN - 1547-5271

IS - 5

ER -

ID: 18764458