RNF138 joins the HR team
Research output: Contribution to journal › Journal article › Research › peer-review
Two studies show that the E3 ubiquitin ligase RNF138 is recruited to DNA double-strand break sites, where it ubiquitylates key repair factors to promote DNA-end resection and homologous recombination. These findings add insights into the multilayered regulatory mechanisms underlying DNA double-strand break repair pathway choice in mammalian cells.
|Journal||Nature Cell Biology|
|Number of pages||3|
|Publication status||Published - Oct 2015|