Pathogens and host immunity in the ancient human oral cavity

Research output: Contribution to journalJournal articleResearchpeer-review

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Pathogens and host immunity in the ancient human oral cavity. / Warinner, Christina; Rodrigues, João F Matias; Vyas, Rounak; Trachsel, Christian; Shved, Natallia; Grossmann, Jonas; Radini, Anita; Hancock, Y; Tito, Raul Y; Fiddyment, Sarah; Speller, Camilla; Hendy, Jessica; Charlton, Sophy; Luder, Hans Ulrich; Salazar-García, Domingo C; Eppler, Elisabeth; Seiler, Roger; Hansen, Lars H.; Samaniego Castruita, Jose Alfredo; Barkow-Oesterreicher, Simon; Teoh, Kai Yik; Kelstrup, Christian; Olsen, Jesper Velgaard; Nanni, Paolo; Kawai, Toshihisa; Willerslev, Eske; von Mering, Christian; Lewis, Cecil M; Collins, Matthew J; Gilbert, M. Thomas P.; Rühli, Frank; Cappellini, Enrico.

In: Nature Genetics, Vol. 46, 2014, p. 336-344.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Warinner, C, Rodrigues, JFM, Vyas, R, Trachsel, C, Shved, N, Grossmann, J, Radini, A, Hancock, Y, Tito, RY, Fiddyment, S, Speller, C, Hendy, J, Charlton, S, Luder, HU, Salazar-García, DC, Eppler, E, Seiler, R, Hansen, LH, Samaniego Castruita, JA, Barkow-Oesterreicher, S, Teoh, KY, Kelstrup, C, Olsen, JV, Nanni, P, Kawai, T, Willerslev, E, von Mering, C, Lewis, CM, Collins, MJ, Gilbert, MTP, Rühli, F & Cappellini, E 2014, 'Pathogens and host immunity in the ancient human oral cavity', Nature Genetics, vol. 46, pp. 336-344. https://doi.org/10.1038/ng.2906

APA

Warinner, C., Rodrigues, J. F. M., Vyas, R., Trachsel, C., Shved, N., Grossmann, J., ... Cappellini, E. (2014). Pathogens and host immunity in the ancient human oral cavity. Nature Genetics, 46, 336-344. https://doi.org/10.1038/ng.2906

Vancouver

Warinner C, Rodrigues JFM, Vyas R, Trachsel C, Shved N, Grossmann J et al. Pathogens and host immunity in the ancient human oral cavity. Nature Genetics. 2014;46:336-344. https://doi.org/10.1038/ng.2906

Author

Warinner, Christina ; Rodrigues, João F Matias ; Vyas, Rounak ; Trachsel, Christian ; Shved, Natallia ; Grossmann, Jonas ; Radini, Anita ; Hancock, Y ; Tito, Raul Y ; Fiddyment, Sarah ; Speller, Camilla ; Hendy, Jessica ; Charlton, Sophy ; Luder, Hans Ulrich ; Salazar-García, Domingo C ; Eppler, Elisabeth ; Seiler, Roger ; Hansen, Lars H. ; Samaniego Castruita, Jose Alfredo ; Barkow-Oesterreicher, Simon ; Teoh, Kai Yik ; Kelstrup, Christian ; Olsen, Jesper Velgaard ; Nanni, Paolo ; Kawai, Toshihisa ; Willerslev, Eske ; von Mering, Christian ; Lewis, Cecil M ; Collins, Matthew J ; Gilbert, M. Thomas P. ; Rühli, Frank ; Cappellini, Enrico. / Pathogens and host immunity in the ancient human oral cavity. In: Nature Genetics. 2014 ; Vol. 46. pp. 336-344.

Bibtex

@article{1f7bc603449449dd9cc00a1ac5a4a824,
title = "Pathogens and host immunity in the ancient human oral cavity",
abstract = "Calcified dental plaque (dental calculus) preserves for millennia and entraps biomolecules from all domains of life and viruses. We report the first, to our knowledge, high-resolution taxonomic and protein functional characterization of the ancient oral microbiome and demonstrate that the oral cavity has long served as a reservoir for bacteria implicated in both local and systemic disease. We characterize (i) the ancient oral microbiome in a diseased state, (ii) 40 opportunistic pathogens, (iii) ancient human-associated putative antibiotic resistance genes, (iv) a genome reconstruction of the periodontal pathogen Tannerella forsythia, (v) 239 bacterial and 43 human proteins, allowing confirmation of a long-term association between host immune factors, 'red complex' pathogens and periodontal disease, and (vi) DNA sequences matching dietary sources. Directly datable and nearly ubiquitous, dental calculus permits the simultaneous investigation of pathogen activity, host immunity and diet, thereby extending direct investigation of common diseases into the human evolutionary past.",
author = "Christina Warinner and Rodrigues, {Jo{\~a}o F Matias} and Rounak Vyas and Christian Trachsel and Natallia Shved and Jonas Grossmann and Anita Radini and Y Hancock and Tito, {Raul Y} and Sarah Fiddyment and Camilla Speller and Jessica Hendy and Sophy Charlton and Luder, {Hans Ulrich} and Salazar-Garc{\'i}a, {Domingo C} and Elisabeth Eppler and Roger Seiler and Hansen, {Lars H.} and {Samaniego Castruita}, {Jose Alfredo} and Simon Barkow-Oesterreicher and Teoh, {Kai Yik} and Christian Kelstrup and Olsen, {Jesper Velgaard} and Paolo Nanni and Toshihisa Kawai and Eske Willerslev and {von Mering}, Christian and Lewis, {Cecil M} and Collins, {Matthew J} and Gilbert, {M. Thomas P.} and Frank R{\"u}hli and Enrico Cappellini",
year = "2014",
doi = "10.1038/ng.2906",
language = "English",
volume = "46",
pages = "336--344",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Pathogens and host immunity in the ancient human oral cavity

AU - Warinner, Christina

AU - Rodrigues, João F Matias

AU - Vyas, Rounak

AU - Trachsel, Christian

AU - Shved, Natallia

AU - Grossmann, Jonas

AU - Radini, Anita

AU - Hancock, Y

AU - Tito, Raul Y

AU - Fiddyment, Sarah

AU - Speller, Camilla

AU - Hendy, Jessica

AU - Charlton, Sophy

AU - Luder, Hans Ulrich

AU - Salazar-García, Domingo C

AU - Eppler, Elisabeth

AU - Seiler, Roger

AU - Hansen, Lars H.

AU - Samaniego Castruita, Jose Alfredo

AU - Barkow-Oesterreicher, Simon

AU - Teoh, Kai Yik

AU - Kelstrup, Christian

AU - Olsen, Jesper Velgaard

AU - Nanni, Paolo

AU - Kawai, Toshihisa

AU - Willerslev, Eske

AU - von Mering, Christian

AU - Lewis, Cecil M

AU - Collins, Matthew J

AU - Gilbert, M. Thomas P.

AU - Rühli, Frank

AU - Cappellini, Enrico

PY - 2014

Y1 - 2014

N2 - Calcified dental plaque (dental calculus) preserves for millennia and entraps biomolecules from all domains of life and viruses. We report the first, to our knowledge, high-resolution taxonomic and protein functional characterization of the ancient oral microbiome and demonstrate that the oral cavity has long served as a reservoir for bacteria implicated in both local and systemic disease. We characterize (i) the ancient oral microbiome in a diseased state, (ii) 40 opportunistic pathogens, (iii) ancient human-associated putative antibiotic resistance genes, (iv) a genome reconstruction of the periodontal pathogen Tannerella forsythia, (v) 239 bacterial and 43 human proteins, allowing confirmation of a long-term association between host immune factors, 'red complex' pathogens and periodontal disease, and (vi) DNA sequences matching dietary sources. Directly datable and nearly ubiquitous, dental calculus permits the simultaneous investigation of pathogen activity, host immunity and diet, thereby extending direct investigation of common diseases into the human evolutionary past.

AB - Calcified dental plaque (dental calculus) preserves for millennia and entraps biomolecules from all domains of life and viruses. We report the first, to our knowledge, high-resolution taxonomic and protein functional characterization of the ancient oral microbiome and demonstrate that the oral cavity has long served as a reservoir for bacteria implicated in both local and systemic disease. We characterize (i) the ancient oral microbiome in a diseased state, (ii) 40 opportunistic pathogens, (iii) ancient human-associated putative antibiotic resistance genes, (iv) a genome reconstruction of the periodontal pathogen Tannerella forsythia, (v) 239 bacterial and 43 human proteins, allowing confirmation of a long-term association between host immune factors, 'red complex' pathogens and periodontal disease, and (vi) DNA sequences matching dietary sources. Directly datable and nearly ubiquitous, dental calculus permits the simultaneous investigation of pathogen activity, host immunity and diet, thereby extending direct investigation of common diseases into the human evolutionary past.

U2 - 10.1038/ng.2906

DO - 10.1038/ng.2906

M3 - Journal article

C2 - 24562188

VL - 46

SP - 336

EP - 344

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

ER -

ID: 102260477