Met1-linked Ubiquitination in Immune Signalling

Research output: Contribution to journalReviewResearchpeer-review

  • Berthe Katrine Fiil
  • Mads Gyrd-Hansen

Methionine 1-linked ubiquitin chains (Met1-Ub), or linear ubiquitin, has emerged as a central post-translational modification in innate immune signalling. Molecular machinery that assembles, senses and, more recently, disassembles Met1-Ub has been identified, and technical advances have enabled identification of physiological substrates for Met1-Ub in response to activation of innate immune receptors. These discoveries have significantly advanced our understanding of how non-degradative ubiquitin modifications control pro-inflammatory responses mediated by nuclear factor κB and mitogen-activated protein kinases. In this review, we will discuss the current data on Met1-Ub function and regulation, and will point to some of the questions that still remain unanswered. This article is protected by copyright. All rights reserved.

Original languageEnglish
JournalF E B S Journal
Issue number19
Pages (from-to)4337-50
Number of pages14
Publication statusPublished - Oct 2014

ID: 119770895