Interplay Between Long Noncoding RNAs and MicroRNAs in Cancer

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  • Russo, Francesco
  • Giulia Fiscon
  • Federica Conte
  • Milena Rizzo
  • Paola Paci
  • Marco Pellegrini

In the last decade noncoding RNAs (ncRNAs) have been extensively studied in several biological processes and human diseases including cancer. microRNAs (miRNAs) are the best-known class of ncRNAs. miRNAs are small ncRNAs of around 20-22 nucleotides (nt) and are crucial posttranscriptional regulators of protein coding genes. Recently, new classes of ncRNAs, longer than miRNAs have been discovered. Those include intergenic noncoding RNAs (lincRNAs) and circular RNAs (circRNAs). These novel types of ncRNAs opened a very exciting field in biology, leading researchers to discover new relationships between miRNAs and long noncoding RNAs (lncRNAs), which act together to control protein coding gene expression. One of these new discoveries led to the formulation of the "competing endogenous RNA (ceRNA) hypothesis." This hypothesis suggests that an lncRNA acts as a sponge for miRNAs reducing their expression and causing the upregulation of miRNA targets. In this chapter we first discuss some recent discoveries in this field showing the mutual regulation of miRNAs, lncRNAs, and protein-coding genes in cancer. We then discuss the general approaches for the study of ceRNAs and present in more detail a recent computational approach to explore the ability of lncRNAs to act as ceRNAs in human breast cancer that has been shown to be, among the others, the most precise and promising.

Original languageEnglish
Title of host publicationComputational Cell Biology
EditorsLouise von Stechow, Alberto Santos Delgado
Number of pages18
PublisherHumana Press
Publication date2018
Pages75-92
Chapter4
ISBN (Print)978-1-4939-8617-0
ISBN (Electronic)978-1-4939-8618-7
DOIs
Publication statusPublished - 2018
SeriesMethods in Molecular Biology
Volume1819
ISSN1064-3745

    Research areas

  • Cancer, Competing endogenous RNAs, Host genes, Long noncoding RNA-derived microRNAs, Long noncoding RNAs, MicroRNAs, Sponge

ID: 210058608