Heat shock response and autophagy - cooperation and control

Research output: Contribution to journalReviewResearchpeer-review

Documents

Protein quality control (proteostasis) depends on constant protein degradation and resynthesis, and is essential for proper homeostasis in systems from single cells to whole organisms. Cells possess several mechanisms and processes to maintain proteostasis. At one end of the spectrum, the heat shock proteins modulate protein folding and repair. At the other end, the proteasome and autophagy as well as other lysosome-dependent systems, function in the degradation of dysfunctional proteins. In this review, we examine how these systems interact to maintain proteostasis. Both the direct cellular data on heat shock control over autophagy and the time course of exercise-associated changes in humans support the model that heat shock response and autophagy are tightly linked. Studying the links between exercise stress and molecular control of proteostasis provides evidence that the heat shock response and autophagy coordinate and undergo sequential activation and downregulation, and that this is essential for proper proteostasis in eukaryotic systems.

Original languageEnglish
JournalAutophagy
Volume11
Issue number2
Pages (from-to)200-213
Number of pages14
ISSN1554-8627
DOIs
Publication statusPublished - 2015

    Research areas

  • Animals, Autophagy/physiology, Heat-Shock Proteins/metabolism, Heat-Shock Response/physiology, Humans, Lysosomes/metabolism, Metabolic Networks and Pathways/physiology, Signal Transduction/physiology

Number of downloads are based on statistics from Google Scholar and www.ku.dk


No data available

ID: 195973479