A Primer on Concepts and Applications of Proteomics in Neuroscience

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A Primer on Concepts and Applications of Proteomics in Neuroscience. / Hosp, Fabian; Mann, Matthias.

In: Neuron, Vol. 96, No. 3, 01.11.2017, p. 558-571.

Research output: Contribution to journalReviewResearchpeer-review

Harvard

Hosp, F & Mann, M 2017, 'A Primer on Concepts and Applications of Proteomics in Neuroscience', Neuron, vol. 96, no. 3, pp. 558-571. https://doi.org/10.1016/j.neuron.2017.09.025

APA

Hosp, F., & Mann, M. (2017). A Primer on Concepts and Applications of Proteomics in Neuroscience. Neuron, 96(3), 558-571. https://doi.org/10.1016/j.neuron.2017.09.025

Vancouver

Hosp F, Mann M. A Primer on Concepts and Applications of Proteomics in Neuroscience. Neuron. 2017 Nov 1;96(3):558-571. https://doi.org/10.1016/j.neuron.2017.09.025

Author

Hosp, Fabian ; Mann, Matthias. / A Primer on Concepts and Applications of Proteomics in Neuroscience. In: Neuron. 2017 ; Vol. 96, No. 3. pp. 558-571.

Bibtex

@article{b0ad9ff7995140818f04edcdd3fbddcd,
title = "A Primer on Concepts and Applications of Proteomics in Neuroscience",
abstract = "The enormous complexity of the central nervous system has impeded its systemic exploration for decades but powerful {"}omic{"} technologies are now pushing forward the frontiers of neuroscience research at an increasing pace. This Primer reviews the most recent progress in mass spectrometry (MS)-based proteomics, focusing on the analysis of whole proteomes, protein-based interactions, and post-translational modifications. We also discuss how advanced workflows help to unravel spatial, regulatory, and temporal aspects of neuronal systems. These tools and approaches have already led to detailed and quantitative proteomic maps of the brain and its signaling architecture, generating new insights into health and disease. We predict that these new approaches will also accelerate biomarker discovery and contribute to novel therapeutics for neurodegenerative and other brain-related diseases.",
keywords = "Animals, Brain, Chromatography, Liquid, Humans, Mass Spectrometry, Neurons, Neurosciences, Proteomics, Journal Article, Review",
author = "Fabian Hosp and Matthias Mann",
note = "Copyright {\circledC} 2017 Elsevier Inc. All rights reserved.",
year = "2017",
month = "11",
day = "1",
doi = "10.1016/j.neuron.2017.09.025",
language = "English",
volume = "96",
pages = "558--571",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "3",

}

RIS

TY - JOUR

T1 - A Primer on Concepts and Applications of Proteomics in Neuroscience

AU - Hosp, Fabian

AU - Mann, Matthias

N1 - Copyright © 2017 Elsevier Inc. All rights reserved.

PY - 2017/11/1

Y1 - 2017/11/1

N2 - The enormous complexity of the central nervous system has impeded its systemic exploration for decades but powerful "omic" technologies are now pushing forward the frontiers of neuroscience research at an increasing pace. This Primer reviews the most recent progress in mass spectrometry (MS)-based proteomics, focusing on the analysis of whole proteomes, protein-based interactions, and post-translational modifications. We also discuss how advanced workflows help to unravel spatial, regulatory, and temporal aspects of neuronal systems. These tools and approaches have already led to detailed and quantitative proteomic maps of the brain and its signaling architecture, generating new insights into health and disease. We predict that these new approaches will also accelerate biomarker discovery and contribute to novel therapeutics for neurodegenerative and other brain-related diseases.

AB - The enormous complexity of the central nervous system has impeded its systemic exploration for decades but powerful "omic" technologies are now pushing forward the frontiers of neuroscience research at an increasing pace. This Primer reviews the most recent progress in mass spectrometry (MS)-based proteomics, focusing on the analysis of whole proteomes, protein-based interactions, and post-translational modifications. We also discuss how advanced workflows help to unravel spatial, regulatory, and temporal aspects of neuronal systems. These tools and approaches have already led to detailed and quantitative proteomic maps of the brain and its signaling architecture, generating new insights into health and disease. We predict that these new approaches will also accelerate biomarker discovery and contribute to novel therapeutics for neurodegenerative and other brain-related diseases.

KW - Animals

KW - Brain

KW - Chromatography, Liquid

KW - Humans

KW - Mass Spectrometry

KW - Neurons

KW - Neurosciences

KW - Proteomics

KW - Journal Article

KW - Review

U2 - 10.1016/j.neuron.2017.09.025

DO - 10.1016/j.neuron.2017.09.025

M3 - Review

C2 - 29096073

VL - 96

SP - 558

EP - 571

JO - Neuron

JF - Neuron

SN - 0896-6273

IS - 3

ER -

ID: 186184545