A 5700 year-old human genome and oral microbiome from chewed birch pitch

Research output: Contribution to journalJournal articleResearchpeer-review

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A 5700 year-old human genome and oral microbiome from chewed birch pitch. / Jensen, Theis Z. T.; Niemann, Jonas; Iversen, Katrine Højholt; Fotakis, Anna K.; Gopalakrishnan, Shyam; Vågene, Åshild J.; Pedersen, Mikkel Winther; Sinding, Mikkel-Holger S.; Ellegaard, Martin R.; Allentoft, Morten E.; Lanigan, Liam T.; Taurozzi, Alberto J.; Nielsen, Sofie Holtsmark; Dee, Michael W.; Mortensen, Martin N.; Christensen, Mads C.; Sørensen, Søren A.; Collins, Matthew J.; Gilbert, M. Thomas P.; Sikora, Martin; Rasmussen, Simon; Schroeder, Hannes.

In: Nature Communications, Vol. 10, 5520, 2019.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Jensen, TZT, Niemann, J, Iversen, KH, Fotakis, AK, Gopalakrishnan, S, Vågene, ÅJ, Pedersen, MW, Sinding, M-HS, Ellegaard, MR, Allentoft, ME, Lanigan, LT, Taurozzi, AJ, Nielsen, SH, Dee, MW, Mortensen, MN, Christensen, MC, Sørensen, SA, Collins, MJ, Gilbert, MTP, Sikora, M, Rasmussen, S & Schroeder, H 2019, 'A 5700 year-old human genome and oral microbiome from chewed birch pitch', Nature Communications, vol. 10, 5520. https://doi.org/10.1038/s41467-019-13549-9

APA

Jensen, T. Z. T., Niemann, J., Iversen, K. H., Fotakis, A. K., Gopalakrishnan, S., Vågene, Å. J., ... Schroeder, H. (2019). A 5700 year-old human genome and oral microbiome from chewed birch pitch. Nature Communications, 10, [5520]. https://doi.org/10.1038/s41467-019-13549-9

Vancouver

Jensen TZT, Niemann J, Iversen KH, Fotakis AK, Gopalakrishnan S, Vågene ÅJ et al. A 5700 year-old human genome and oral microbiome from chewed birch pitch. Nature Communications. 2019;10. 5520. https://doi.org/10.1038/s41467-019-13549-9

Author

Jensen, Theis Z. T. ; Niemann, Jonas ; Iversen, Katrine Højholt ; Fotakis, Anna K. ; Gopalakrishnan, Shyam ; Vågene, Åshild J. ; Pedersen, Mikkel Winther ; Sinding, Mikkel-Holger S. ; Ellegaard, Martin R. ; Allentoft, Morten E. ; Lanigan, Liam T. ; Taurozzi, Alberto J. ; Nielsen, Sofie Holtsmark ; Dee, Michael W. ; Mortensen, Martin N. ; Christensen, Mads C. ; Sørensen, Søren A. ; Collins, Matthew J. ; Gilbert, M. Thomas P. ; Sikora, Martin ; Rasmussen, Simon ; Schroeder, Hannes. / A 5700 year-old human genome and oral microbiome from chewed birch pitch. In: Nature Communications. 2019 ; Vol. 10.

Bibtex

@article{06045404031d4c288b6a826db0cf6057,
title = "A 5700 year-old human genome and oral microbiome from chewed birch pitch",
abstract = "The rise of ancient genomics has revolutionised our understanding of human prehistory but this work depends on the availability of suitable samples. Here we present a complete ancient human genome and oral microbiome sequenced from a 5700 year-old piece of chewed birch pitch from Denmark. We sequence the human genome to an average depth of 2.3× and find that the individual who chewed the pitch was female and that she was genetically more closely related to western hunter-gatherers from mainland Europe than hunter-gatherers from central Scandinavia. We also find that she likely had dark skin, dark brown hair and blue eyes. In addition, we identify DNA fragments from several bacterial and viral taxa, including Epstein-Barr virus, as well as animal and plant DNA, which may have derived from a recent meal. The results highlight the potential of chewed birch pitch as a source of ancient DNA.",
author = "Jensen, {Theis Z. T.} and Jonas Niemann and Iversen, {Katrine H{\o}jholt} and Fotakis, {Anna K.} and Shyam Gopalakrishnan and V{\aa}gene, {{\AA}shild J.} and Pedersen, {Mikkel Winther} and Sinding, {Mikkel-Holger S.} and Ellegaard, {Martin R.} and Allentoft, {Morten E.} and Lanigan, {Liam T.} and Taurozzi, {Alberto J.} and Nielsen, {Sofie Holtsmark} and Dee, {Michael W.} and Mortensen, {Martin N.} and Christensen, {Mads C.} and S{\o}rensen, {S{\o}ren A.} and Collins, {Matthew J.} and Gilbert, {M. Thomas P.} and Martin Sikora and Simon Rasmussen and Hannes Schroeder",
year = "2019",
doi = "10.1038/s41467-019-13549-9",
language = "English",
volume = "10",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - A 5700 year-old human genome and oral microbiome from chewed birch pitch

AU - Jensen, Theis Z. T.

AU - Niemann, Jonas

AU - Iversen, Katrine Højholt

AU - Fotakis, Anna K.

AU - Gopalakrishnan, Shyam

AU - Vågene, Åshild J.

AU - Pedersen, Mikkel Winther

AU - Sinding, Mikkel-Holger S.

AU - Ellegaard, Martin R.

AU - Allentoft, Morten E.

AU - Lanigan, Liam T.

AU - Taurozzi, Alberto J.

AU - Nielsen, Sofie Holtsmark

AU - Dee, Michael W.

AU - Mortensen, Martin N.

AU - Christensen, Mads C.

AU - Sørensen, Søren A.

AU - Collins, Matthew J.

AU - Gilbert, M. Thomas P.

AU - Sikora, Martin

AU - Rasmussen, Simon

AU - Schroeder, Hannes

PY - 2019

Y1 - 2019

N2 - The rise of ancient genomics has revolutionised our understanding of human prehistory but this work depends on the availability of suitable samples. Here we present a complete ancient human genome and oral microbiome sequenced from a 5700 year-old piece of chewed birch pitch from Denmark. We sequence the human genome to an average depth of 2.3× and find that the individual who chewed the pitch was female and that she was genetically more closely related to western hunter-gatherers from mainland Europe than hunter-gatherers from central Scandinavia. We also find that she likely had dark skin, dark brown hair and blue eyes. In addition, we identify DNA fragments from several bacterial and viral taxa, including Epstein-Barr virus, as well as animal and plant DNA, which may have derived from a recent meal. The results highlight the potential of chewed birch pitch as a source of ancient DNA.

AB - The rise of ancient genomics has revolutionised our understanding of human prehistory but this work depends on the availability of suitable samples. Here we present a complete ancient human genome and oral microbiome sequenced from a 5700 year-old piece of chewed birch pitch from Denmark. We sequence the human genome to an average depth of 2.3× and find that the individual who chewed the pitch was female and that she was genetically more closely related to western hunter-gatherers from mainland Europe than hunter-gatherers from central Scandinavia. We also find that she likely had dark skin, dark brown hair and blue eyes. In addition, we identify DNA fragments from several bacterial and viral taxa, including Epstein-Barr virus, as well as animal and plant DNA, which may have derived from a recent meal. The results highlight the potential of chewed birch pitch as a source of ancient DNA.

U2 - 10.1038/s41467-019-13549-9

DO - 10.1038/s41467-019-13549-9

M3 - Journal article

C2 - 31848342

AN - SCOPUS:85076602036

VL - 10

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

M1 - 5520

ER -

ID: 232908994