The NNF Center for Protein Research

  1. 2019
  2. Published

    Stabilization of chromatin topology safeguards genome integrity

    Ochs, F., Karemore, Gopal, Miron, E., Brown, J., Sedlackova, Hana, Rask, M., Lampe, M., Buckle, V., Schermelleh, L., Lukas, Jiri & Lukas, Claudia, 2019, In : Nature. 574, 7779, p. 571-574 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Structural Basis of BRCC36 Function in DNA Repair and Immune Regulation

    Rabl, J., Bunker, R. D., Schenk, A. D., Cavadini, S., Gill, M. E., Abdulrahman, W., Andrés-Pons, A., Luijsterburg, M. S., Ibrahim, A. F. M., Branigan, E., Aguirre, J. D., Marceau, A. H., Guérillon, C., Bouwmeester, T., Hassiepen, U., Peters, A. H. F. M., Renatus, M., Gelman, L., Rubin, S. M., Mailand, Niels, van Attikum, H., Hay, R. T. & Thomä, N. H., 2019, In : Molecular Cell. 75, 3, p. 483-497.e9 25 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Structure and Function of the Branched Receptor-Binding Complex of Bacteriophage CBA120

    Plattner, M., Shneider, M. M., Arbatsky, N. P., Shashkov, A. S., Chizhov, A. O., Nazarov, S., Prokhorov, N. S., Taylor, Nicholas M I, Buth, S. A., Gambino, Michela, Gencay, Y. E., Brøndsted, Lone, Kutter, E. M., Knirel, Y. A. & Leiman, P. G., 2019, In : Journal of Molecular Biology. 431, 19, p. 3718-3739

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Structure of Csx1-cOA4 complex reveals the basis of RNA decay in Type III-B CRISPR-Cas

    Molina, Rafael, Stella, Stefano, Feng, M., Sofos, N., Jauniskis, V., Pozdnyakova, I., López-Méndez, B., She, Q. & Montoya, Guillermo, 2019, In : Nature Communications. 10, 14 p., 4302.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Survival prediction in intensive-care units based on aggregation of long-term disease history and acute physiology: a retrospective study of the Danish National Patient Registry and electronic patient records

    Nielsen, Annelaura Bach, Thorsen-Meyer, H. C., Belling, Kirstine G, Nielsen, Anna Pors, Thomas, C. E., Chmura, Piotr Jaroslaw, Lademann, M., Moseley, Pope Lloyd, Heimann, M., Dybdahl, L., Spangsege, L., Hulsen, P., Perner, Anders & Brunak, Søren, 2019, In : The Lancet Digital Health. 1, 2, p. e78-e89 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Sweet google O’ mine - The importance of online search engines for MS-facilitated, database-independent identification of peptide-encoded book prefaces: A EUPA YPIC challenge entry

    Hogrebe, A. & Jersie-Christensen, R. R., 2019, In : EuPA Open Proteomics. 22-23, p. 14-18 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    TH2BS11ph histone mark is enriched in the unsynapsed axes of the XY body and predominantly associates with H3K4me3-containing genomic regions in mammalian spermatocytes

    Mahadevan, I. A., Pentakota, Satya Krishna, Roy, R., Bhaduri, U. & Satyanarayana Rao, M. R., 2019, In : Epigenetics & Chromatin. 12, 1, 23 p., 53.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    TRAIP drives replisome disassembly and mitotic DNA repair synthesis at sites of incomplete DNA replication

    Sonneville, R., Bhowmick, Rahul, Hoffmann, Saskia, Mailand, Niels, Hickson, Ian David & Labib, K., 2019, In : eLife. 8, 19 p., e48686.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Tail Structure and Dynamics

    Bhatt, Shweta, Leiman, P. G. & Taylor, Nicholas M I, 2019, Reference Module in Life Sciences. Elsevier

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

  11. Published

    The bio.tools registry of software tools and data resources for the life sciences

    Ison, J., Ienasescu, H., Chmura, Piotr Jaroslaw, Rydza, E., Ménager, H., Kalaš, M., Schwämmle, V., Grüning, B., Beard, N., Lopez, R., Duvaud, S., Stockinger, H., Persson, B., Vařeková, R. S., Raček, T., Vondrášek, J., Peterson, H., Salumets, A., Jonassen, I., Hooft, R., Nyrönen, T., Valencia, A., Capella, S., Gelpí, J., Zambelli, F., Savakis, B., Leskošek, B., Rapacki, K., Blanchet, C., Jimenez, R., Oliveira, A., Vriend, G., Collin, O., van Helden, J., Løngreen, P. & Brunak, Søren, 2019, In : Genome Biology. 20, 1, 4 p., 164.

    Research output: Contribution to journalLetterResearchpeer-review

  12. Published

    The CMG Helicase Bypasses DNA-Protein Cross-Links to Facilitate Their Repair

    Sparks, J. L., Chistol, G., Gao, A. O., Räschle, M., Larsen, Nicolai Balle, Mann, Matthias, Duxin, Julien & Walter, J. C., 2019, In : Cell. 176, 1-2, p. 167-181.e21 36 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    The Case for Proteomics and Phospho-Proteomics in Personalized Cancer Medicine

    Doll, S., Gnad, F. & Mann, Matthias, 2019, In : Proteomics - Clinical Applications. 13, 2, 10 p., e1800113.

    Research output: Contribution to journalReviewResearchpeer-review

  14. Published

    The RIF1-PP1 Axis Controls Abscission Timing in Human Cells

    Bhowmick, Rahul, Thakur, Roshan Singh, Venegas, A. B., Liu, Ying, Nilsson, Jakob, Barisic, Marin & Hickson, Ian David, 2019, In : Current Biology. 29, 7, p. 1232-1242.e5

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    The Role of TTP Phosphorylation in the Regulation of Inflammatory Cytokine Production by MK2/3

    Ronkina, N., Shushakova, N., Tiedje, C., Yakovleva, T., Tollenaere, M. A. X., Scott, A., Batth, Tanveer Singh, Olsen, Jesper Velgaard, Helmke, A., Bekker-Jensen, Simon Holst, Clark, A. R., Kotlyarov, A. & Gaestel, M., 2019, In : Journal of immunology (Baltimore, Md. : 1950). 203, 8, p. 2291-2300 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    The ever expanding scope of electrospray mass spectrometry-a 30 year journey

    Mann, Matthias, 2019, In : Nature Communications. 10, 3744.

    Research output: Contribution to journalComment/debateResearch

  17. Published

    The first step towards personalized risk prediction for common epilepsies

    Hansen, Thomas Folkmann & Møller, R. S., 2019, In : Brain. 142, p. 3316-3318 3 p.

    Research output: Contribution to journalComment/debateResearch

  18. Published

    The forebrain synaptic transcriptome is organized by clocks but its proteome is driven by sleep

    Noya, S. B., Colameo, D., Brüning, F., Spinnler, A., Mircsof, D., Opitz, L., Mann, Matthias, Tyagarajan, S. K., Robles, M. S. & Brown, S. A., 2019, In : Science. 366, 6462, eaav2642 .

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    The human endogenous metabolome as a pharmacology baseline for drug discovery

    Bofill, A., Jalencas, X., Oprea, T. I. & Mestres, J., 2019, In : Drug Discovery Today. 24, 9-12, p. 1806-1820

    Research output: Contribution to journalReviewResearchpeer-review

  20. Published

    The liver-alpha cell axis and type 2 diabetes

    Albrechtsen, Nicolai Jacob Wewer, Pedersen, J., Galsgaard, Katrine Douglas, Winther-Sørensen, Marie, Suppli, M. P., Janah, L., Gromada, J., Vilstrup, H., Knop, Filip Krag & Holst, Jens Juul, 2019, In : Endocrine Reviews. 40, 5, p. 1353-1366

    Research output: Contribution to journalReviewResearchpeer-review

  21. Published

    The p97-Ataxin 3 complex regulates homeostasis of the DNA damage response E3 ubiquitin ligase RNF8

    Singh, A. N., Oehler, J., Torrecilla, I., Kilgas, S., Li, S., Vaz, B., Guerillon, C., Fielden, J., Esperanza Hernandez-Carralero, Cabrera, E., Tullis, I. D. C., Meerang, M., Barber, P. R., Freire, R., Parsons, J., Vojnovic, B., Kiltie, A. E., Mailand, Niels & Ramadan, K., 2019, In : EMBO Journal. 38, 25 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    The use of systems biology in chemical risk assessment

    Aguayo Orozco, Alejandro, Taboureau, Olivier Thierry & Brunak, Søren, 2019, In : Current Opinion in Toxicology. 15, p. 48-54 7 p.

    Research output: Contribution to journalReviewResearchpeer-review

  23. Published

    Top-Down and Intact Protein Mass Spectrometry Data Visualization for Proteoform Analysis Using VisioProt-MS

    Lesne, J., Bousquet, M., Marcoux, J. & Locard-Paulet, Marie, 2019, In : Bioinformatics and Biology Insights. 13, 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Transcriptome analysis in patients with temporal lobe epilepsy

    Kjær, C., Barzaghi, G., Bak, Lasse Kristoffer, Goetze, Jens P. , Yde, C. W., Woldbye, David Paul Drucker, Pinborg, Lars Hageman & Jensen, Lars Juhl, 2019, In : Brain. 142, 10, p. 49-64 16 p., e55.

    Research output: Contribution to journalLetterResearchpeer-review

  25. Published

    Transcriptome landscape of protein-coding genes and long noncoding RNAs in the colon and blood of DSS-induced mouse model of Acute ulcerative colitis

    Yarani, R., Palasca, O., Doncheva, Nadezhda Tsankova, Anthon, Christian, Pilecki, B., Litman, Thomas, Holmskov, U., Jensen, Lars Juhl, Gorodkin, Jan & Pociot, Flemming, 2019, In : Journal of Crohn's and Colitis. 13, p. S129-S130

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  26. Published

    Unraveling ancestry, kinship, and violence in a Late Neolithic mass grave

    Schroeder, Hannes, Margaryan, Ashot, Szmyt, M., Theulot, B., Włodarczak, P., Rasmussen, Simon, Gopalakrishnan, Shyam, Szczepanek, A., Konopka, T., Jensen, Theis Zetner Trolle, Witkowska, B., Wilk, S., Przybyła, M. M., Pospieszny, Ł., Sjögren, K., Belka, Z., Olsen, J., Kristiansen, K., Willerslev, Eske, Frei, K. M., Sikora, Martin, Johannsen, N. N. & Allentoft, Morten Erik, 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 22, p. 10705-10710

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Use of Computational Biochemistry for Elucidating Molecular Mechanisms of Nitric Oxide Synthase

    Bignon, E., Rizza, S., Filomeni, G. & Papaleo, Elena, 2019, In : Computational and Structural Biotechnology Journal. 17, p. 415-429 15 p.

    Research output: Contribution to journalReviewResearchpeer-review

  28. Published

    What outcomes are important to patients with mild cognitive impairment or Alzheimer's disease, their caregivers, and health-care professionals? A systematic review

    Tochel, C., Smith, M., Baldwin, H., Gustavsson, A., Ly, A., Bexelius, C., Nelson, M., Bintener, C., Fantoni, E., Garre-Olmo, J., Janssen, O., Jindra, C., Jørgensen, Isabella Friis, McKeown, A., Öztürk, B., Ponjoan, A., Potashman, M. H., Reed, C., Roncancio-Diaz, E., Vos, S., Sudlow, C. & ROADMAP consortium, R. C., 2019, In : Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 11, p. 231-247 17 p.

    Research output: Contribution to journalReviewResearchpeer-review

  29. Published

    eggNOG 5.0: a hierarchical, functionally and phylogenetically annotated orthology resource based on 5090 organisms and 2502 viruses

    Huerta-Cepas, J., Szklarczyk, D., Heller, D., Hernández-Plaza, A., Forslund, S. K., Cook, H., Mende, D. R., Letunic, I., Rattei, T., Jensen, Lars Juhl, von Mering, C. & Bork, P., 2019, In : Nucleic Acids Research. 47, D1, p. D309-D314 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    sAOP: linking chemical stressors to adverse outcomes pathway networks

    Aguayo Orozco, Alejandro, Audouze, K., Siggaard, T., Barouki, R., Brunak, Søren & Taboureau, Olivier Thierry, 2019, In : Bioinformatics. 2 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. 2018
  32. Published

    Conformational Activation Promotes CRISPR-Cas12a Catalysis and Resetting of the Endonuclease Activity

    Stella, Stefano, Mesa, Pablo, Thomsen, J., Paul, Bijoya, Alcón, P., Jensen, Simon Bo, Saligram, B., Moses, M. E., Hatzakis, Nikos & Montoya, Guillermo, 13 Dec 2018, In : Cell. 175, 7, p. 1856-1871.e21 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    GLP-1 Is a Coronary Artery Vasodilator in Humans

    Clarke, S. J., Giblett, J. P., Yang, L. L., Hubsch, A., Zhao, T., Aetesam-ur-Rahman, M., West, N. E. J., O'Sullivan, M., Figg, N., Bennett, M., Albrechtsen, Nicolai Jacob Wewer, Deacon, Carolyn F., Cheriyan, J. & Hoole, S. P., 20 Nov 2018, In : Journal of the American Heart Association. 7, 22, 14 p., e010321.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Integrated proximal proteomics reveals IRS2 as a determinant of cell survival in ALK-driven neuroblastoma

    Emdal, Kristina Bennet, Pedersen, A., Bekker-Jensen, D. B., Lundby, Alicia, Claeys, S., De Preter, K., Speleman, F., Francavilla, C. & Olsen, Jesper Velgaard, 20 Nov 2018, In : Science signaling. 11, 557, p. 1-17 17 p., eaap9752.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published
  36. Published

    WebCircRNA: Classifying the Circular RNA Potential of Coding and Noncoding RNA.

    Pan, X., Xiong, K., Anthon, Christian, Hyttel, Poul, Freude, Kristine, Jensen, Lars Juhl & Gorodkin, Jan, 6 Nov 2018, In : Genes. 9, 11, 11 p., 536.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Recovery of gut microbiota of healthy adults following antibiotic exposure

    Palleja, A., Mikkelsen, K. H., Forslund, S. K., Kashani, A., Allin, Kristine Højgaard, Nielsen, Trine, Hansen, Tue Haldor, Liang, S., Feng, Q., Zhang, C., Pyl, P. T., Coelho, L. P., Yang, H., Wang, J., Typas, A., Nielsen, M. F., Nielsen, H. B., Bork, P., Wang, J., Vilsbøll, Tina, Hansen, Torben, Knop, Filip Krag, Arumugam, Mani & Pedersen, Oluf Borbye, Nov 2018, In : Nature Microbiology. 3, 11, p. 1255-1265 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Ancient proteins from ceramic vessels at Çatalhöyük West reveal the hidden cuisine of early farmers

    Hendy, J., Colonese, A. C., Franz, I., Fernandes, R., Fischer, R., Orton, D., Lucquin, A., Spindler, L., Anvari, J., Stroud, E., Biehl, P. F., Speller, C., Boivin, N., Mackie, Meaghan, Jersie-Christensen, R. R., Olsen, Jesper Velgaard, Collins, Matthew James, Craig, O. E. & Rosenstock, E., 3 Oct 2018, In : Nature Communications. 9, 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Præcisionskardiologi

    Haue, Amalie Dahl, Vissing, C. R., Tfelt-Hansen, Jacob, Brunak, Søren, Bundgård, Henning & Weeke, P. E., 1 Oct 2018, In : Ugeskrift for Laeger. 180, 20A, p. 1851-54

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Consistent Prediction of Mutation Effect on Drug Binding in HIV-1 Protease Using Alchemical Calculations

    Bastys, T., Gapsys, V., Doncheva, Nadezhda Tsankova, Kaiser, R., De Groot, B. L. & Kalinina, O. V., 10 Jul 2018, In : Journal of Chemical Theory and Computation. 14, 7, p. 3397-3408

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Effective lock-in strategy for proteomic analysis of corona complexes bound to amino-free ligands of gold nanoparticles

    Zhou, M., Tang, M., Li, S., Peng, L., Huang, H., Fang, Q., Liu, Z., Xie, P., Li, G. & Zhou, J., 9 Jul 2018, In : Nanoscale. 10, 26, p. 12413-12423 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Assessment of the analgesic dipyrone as a possible (anti) androgenic endocrine disruptor

    Passoni, M. T., Kristensen, Maja Nørgaard, Morais, R. N., Woitkowiak, C., Boareto, A. C., da Silva Amaral, B. A., Grechi, N., Dalsenter, P. R., Munkboel, C. H., Styrishave, Bjarne, Kristensen, D. M., Gomes, C., van Ravenzwaay, B. & Martino-Andrade, A. J., 15 Mar 2018, In : Toxicology Letters. 285, p. 139-147

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Familial co-occurrence of congenital heart defects follows distinct patterns

    Ellesøe, S. G., Workman, C. T., Bouvagnet, P., Loffredo, C. A., McBride, K. L., Hinton, R. B., van Engelen, K., Gertsen, E. C., Mulder, B. J. M., Postma, A. V., Anderson, R. H., Hjortdal, V. E., Brunak, Søren & Larsen, Lars Allan, Mar 2018, In : European Heart Journal. 39, 12, p. 1015–1022

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    The Ebola Virus Nucleoprotein Recruits the Host PP2A-B56 Phosphatase to Activate Transcriptional Support Activity of VP30

    Kruse, Thomas, Biedenkopf, N., Hertz, Emil Peter Thrane, Dietzel, E., Stalmann, G., López-Méndez, B., Davey, N. E., Nilsson, Jakob & Becker, S., 4 Jan 2018, In : Molecular Cell. 69, 1, p. 136-145 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    miRandola 2017: a curated knowledge base of non-invasive biomarkers

    Russo, Francesco, Di Bella, S., Vannini, F., Berti, G., Scoyni, F., Cook, H. V., Santos, A., Nigita, G., Bonnici, V., Laganà, A., Geraci, F., Pulvirenti, A., Giugno, R., De Masi, F., Belling, Kirstine G, Jensen, Lars Juhl, Brunak, Søren, Pellegrini, M. & Ferro, A., 4 Jan 2018, In : Nucleic Acids Research. 46, D1, p. D354-D359 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Performance evaluation of the Q Exactive HF-X for shotgun proteomics

    Kelstrup, C. D., Bekker-Jensen, D. B., Arrey, T. N., Hogrebe, A., Harder, A. & Olsen, Jesper Velgaard, Jan 2018, In : Journal of Proteome Research. 17, 1, p. 727-738 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    LocText: relation extraction of protein localizations to assist database curation

    Cejuela, J. M., Vinchurkar, S., Goldberg, T., Prabhu Shankar, M. S., Baghudana, A., Bojchevski, A., Uhlig, C., Ofner, A., Raharja-Liu, P., Jensen, Lars Juhl & Rost, B., 2018, In : BMC Bioinformatics. 19, p. 1-11 15.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    A Novel Familial Cardiac Arrhythmia Syndrome with Widespread ST-Segment Depression

    Bundgård, Henning, Jøns, C., Lodder, E. M., Izarzugaza, J. M. G., Romero Herrera, Jose Alejandro, Pehrson, S., Tfelt-Hansen, Jacob, Ahlberg, G., Olesen, Morten Steen Salling, Holst, A. G., Wellens, H., de Villiers, C., Hastings, R., Stuart, G., Brunak, Søren, Wilde, A. A. M., Watkins, H. & Christensen, A. H., 2018, In : The New England Journal of Medicine. 379, 18, p. 1780-1781 2 p.

    Research output: Contribution to journalComment/debateResearch

  49. Published

    A Type III-B Cmr effector complex catalyzes the synthesis of cyclic oligoadenylate second messengers by cooperative substrate binding

    Han, W., Stella, Stefano, Zhang, Y., Guo, Tong, Sulek, Karolina, Peng-Lundgren, L., Montoya, Guillermo & She, Q., 2018, In : Nucleic Acids Research. 46, 19, p. 10319-10330 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    A comprehensive and quantitative comparison of text-mining in 15 million full-text articles versus their corresponding abstracts

    Westergaard, David, Stærfeldt, H., Tønsberg, C., Jensen, Lars Juhl & Brunak, Søren, 2018, In : PLoS Computational Biology. 14, 2, 16 p., e1005962.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    A computational framework to integrate high-throughput "-omics" datasets for the identification of potential mechanistic links

    Pedersen, Helle Krogh, Forslund, S. K., Gudmundsdottir, V., Petersen, A. Ø., Hildebrand, F., Hyötyläinen, T., Nielsen, Trine, Hansen, Torben, Bork, P., Ehrlich, S. D., Brunak, Søren, Oresic, M., Pedersen, Oluf Borbye & Nielsen, H. B., 2018, In : Nature Protocols. 13, 12, p. 2781-2800 20 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. Published

    A novel LC system embeds analytes in pre-formed gradients for rapid, ultra-robust proteomics

    Bache, N., Geyer, P. E., Bekker-Jensen, D. B., Hørning, O., Falkenby, L., Treit, P. V., Doll, S., Paron, I., Müller, J. B., Meier, F., Olsen, Jesper Velgaard, Vorm, O. & Mann, Matthias, 2018, In : Molecular and Cellular Proteomics. 17, 11, p. 2284-2296 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. Published

    ADAM12-mediated shedding of basigin controls the subcellular localization and lactate transport of MCT4 and enhances collagen degradation in cancer cells: [Meeting Abstract}

    Albrechtsen, Reidar, Albrechtsen, Nicolai Jacob Wewer & Kveiborg, Marie, 2018, In : International Journal of Experimental Pathology. 99, 6, p. A25-A25

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  54. Published

    Accurate Recycling of Parental Histones Reproduces the Histone Modification Landscape during DNA Replication

    Reveron-Gomez, Nazaret, González-Aguilera, C., Stewart-Morgan, Kathleen, Petryk, N., Flury, V., Graziano, Simona, Johansen, Jens Vilstrup, Jakobsen, J. S., Alabert, C. & Groth, Anja, 2018, In : Molecular Cell. 72, 2, p. 239-249 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  55. Published

    Accurate genotyping across variant classes and lengths using variant graphs

    Sibbesen, J. A., Maretty, L., Krogh, Anders, Petersen, Bent, Sibbesen, J. A., Liu, S., Have, C. T., Bork-Jensen, J., Guo, X., Hansen, Torben, Krogh, Anders, Sørensen, Thorkild I.A., Pedersen, Oluf Borbye, Wang, J. & Brunak, Søren, 2018, In : Nature Genetics. 50, p. 1054-1059 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  56. Published

    Alternative translation initiation generates a functionally distinct isoform of the stress-activated kinase MK2

    Trulley, P., Snieckute, Goda, Bekker-Jensen, D. B., Menon, M. B., Freund, R., Kotlyarov, A., Olsen, Jesper Velgaard, Diaz-Muñoz, M. D., Turner, M., Bekker-Jensen, Simon Holst, Gaestel, M. & Tiedje, C., 2018, In : bioRxiv. 46 p.

    Research output: Contribution to journalJournal articleResearch

  57. Published

    An Integrative Approach to Virus-Host Protein-Protein Interactions

    Cook, H. V. & Jensen, Lars Juhl, 2018, Computational Cell Biology. von Stechow, L. & Delgado, A. S. (eds.). Humana Press, p. 175-196 22 p. (Methods in Molecular Biology, Vol. 1819).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  58. Published

    Analysis of Time-Series Gene Expression Data to Explore Mechanisms of Chemical-Induced Hepatic Steatosis Toxicity

    Aguayo Orozco, Alejandro, Bois, F. Y., Brunak, Søren & Taboureau, Olivier Thierry, 2018, In : Frontiers in Genetics. 9, p. 1-15 396.

    Research output: Contribution to journalJournal articleResearchpeer-review

  59. Published

    Analysis of a gene panel for targeted sequencing of colorectal cancer samples

    Jensen, K. H., Izarzugaza, J. M. G., Juncker, A. S., Hansen, R. B., Hansen, T. F., Timshel, P., Blondal, T., Jensen, T. S., Rygaard-Hjalsted, E., Mouritzen, P., Thorsen, M., Wernersson, R., Nielsen, H. B., Jakobsen, A., Brunak, Søren & Sørensen, F. B., 2018, In : OncoTarget. 9, 10, p. 9043-9060 18 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  60. Published

    Arginine Methylation by PRMT2 Controls the Functions of the Actin Nucleator Cobl

    Hou, W., Nemitz, S., Schopper, S., Nielsen, Michael Lund, Kessels, M. M. & Qualmann, B., 2018, In : Developmental Cell. 45, 2, p. 262-275.E8

    Research output: Contribution to journalJournal articleResearchpeer-review

  61. Published

    Benchmarking common quantification strategies for large-scale phosphoproteomics

    Hogrebe, A., von Stechow, L., Bekker-Jensen, D. B., Weinert, B. T., Kelstrup, C. D. & Olsen, Jesper Velgaard, 2018, In : Nature Communications. 9, 1, p. 1-13 1045.

    Research output: Contribution to journalJournal articleResearchpeer-review

  62. Published

    Benchmarking the HLA typing performance of Polysolver and Optitype in 50 Danish parental trios

    Matey-Hernandez, M. L., Danish Pan Genome Consortium, D. P. G. C., Brunak, Søren, Izarzugaza, J. M. G., Sørensen, L. M., Petersen, Bent, Sibbesen, J. A., Liu, S., Belling, Kirstine G, Have, C. T., Bork-Jensen, J., Sun, J., Hansen, Torben, Krogh, Anders, Sørensen, Thorkild I.A., Pedersen, Oluf Borbye, Wang, J., Eiberg, Hans Rudolf Lytchoff & Kristiansen, Karsten, 2018, In : BMC Bioinformatics. 19, p. 1-12 239.

    Research output: Contribution to journalJournal articleResearchpeer-review

  63. Published

    Blood parameters in a population of blood donors are not affected by hidradenitis suppurativa

    Theut Riis, P., Sigsgaard, V., Pedersen, O. B., Olsen, J., Rigas, A. S., Dinh, K. M., Brodersen, T., Ullum, Henrik, Erikstrup, C., Paarup, H. M., Nielsen, K. R., Petersen, M. S., Burgdorf, K. S., Hjalgrim, H., Rostgaard, K., Banasik, Karina & Jemec, Gregor, 2018, In : European Journal of Dermatology. 28, 3, p. 424-425 2 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  64. Published

    BoxCar acquisition method enables single-shot proteomics at a depth of 10,000 proteins in 100 minutes

    Meier, F., Geyer, P. E., Virreira Winter, S., Cox, J. & Mann, Matthias, 2018, In : Nature Methods. 15, 6, p. 440-448 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  65. Published

    Comorbidity landscape of the Danish patient population affected by chromosomal abnormalities

    Russo, Francesco, Jørgensen, Isabella Friis, Westergaard, David, Jensen, A. B., Hjaltelin, Jessica Xin, Belling, Kirstine G & Brunak, Søren, 2018, In : European Journal of Human Genetics. 26, p. 697-698

    Research output: Contribution to journalConference abstract in journalResearch

  66. Published

    Comorbidity of migraine with ADHD in adults

    Hansen, Thomas Folkmann, Hoeffding, L. K., Kogelman, L., Haspang, T. M., Ullum, Henrik, Sørensen, E., Erikstrup, C., Pedersen, O. B., Nielsen, K. R., Hjalgrim, H., Paarup, H. M., Werge, Thomas & Burgdorf, K., 2018, In : BMC Neurology. 18, 1, p. 1-9 147.

    Research output: Contribution to journalJournal articleResearchpeer-review

  67. Published

    Computational Structural Biology of S-nitrosylation of Cancer Targets

    Bignon, E., Allega, M. F., Lucchetta, M., Tiberti, M. & Papaleo, Elena, 2018, In : Frontiers in Oncology. 8, p. 1-23 272.

    Research output: Contribution to journalReviewResearchpeer-review

  68. Published

    Constructing a cell-type resolved human liver proteome atlas: THU-034

    Niu, Lili, Geyer, P. & Mann, Matthias, 2018, In : Journal of Hepatology. 68, p. S138-S139

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  69. Published

    Contractile injection systems of bacteriophages and related systems

    Taylor, Nicholas M I, van Raaij, M. J. & Leiman, P. G., 2018, In : Molecular Microbiology. 108, 1, p. 6-15 10 p.

    Research output: Contribution to journalReviewResearchpeer-review

  70. Published

    Control of endothelial cell tube formation by Notch ligand intracellular domain interactions with activator protein 1 (AP-1)

    Forghany, Z., Robertson, F., Lundby, Alicia, Olsen, Jesper Velgaard & Baker, D. A., 2018, In : Journal of Biological Chemistry. 293, 4, p. 1229-1242 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  71. Published

    Cryo-EM structures of a human ABCG2 mutant trapped in ATP-bound and substrate-bound states

    Manolaridis, I., Jackson, S. M., Taylor, Nicholas M I, Kowal, J., Stahlberg, H. & Locher, K. P., 2018, In : Nature. 563, 7731, p. 426-430 5 p.

    Research output: Contribution to journalLetterResearchpeer-review

  72. Published

    DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity

    Gupta, R., Somyajit, Kumar, Narita, Takeo, Maskey, E., Stanlie, A., Kremer, M., Typas, Dimitris, Lammers, M., Mailand, Niels, Nussenzweig, A., Lukas, Jiri & Choudhary, Chuna Ram, 2018, In : Cell. 173, 4, p. 972-988

    Research output: Contribution to journalJournal articleResearchpeer-review

  73. Published

    DNA damage-induced dynamic changes in abundance and cytosol-nuclear translocation of proteins involved in translational processes, metabolism, and autophagy

    Bennetzen, M. V., Kosar, M., Bunkenborg, J., Payne, M. R., Bartkova, J., Lindström, M. S., Lukas, Jiri, Andersen, J. S., Bartek, J. & Larsen, D. H., 2018, In : Cell Cycle. 17, 17, p. 2146-2163

    Research output: Contribution to journalJournal articleResearchpeer-review

  74. Published

    Darkness in the Human Gene and Protein Function Space: Widely Modest or Absent Illumination by the Life Science Literature and the Trend for Fewer Protein Function Discoveries Since 2000

    Sinha, S., Eisenhaber, B., Jensen, Lars Juhl, Kalbuaji, B. & Eisenhaber, F., 2018, In : Proteomics. 18, 21-22, p. 1-13 e1800093.

    Research output: Contribution to journalJournal articleResearchpeer-review

  75. Published

    Deletion of APC7 or APC16 Allows Proliferation of Human Cells without the Spindle Assembly Checkpoint

    Wild, T., Budzowska, Magdalena, Hellmuth, S., Eibes, S., Karemore, Gopal, Barisic, Marin, Stemmann, O. & Choudhary, Chuna Ram, 2018, In : Cell Reports. 25, 9, 18 p., 2317-2328.e5.

    Research output: Contribution to journalJournal articleResearchpeer-review

  76. Published

    Dissecting Multi-protein Signaling Complexes by Bimolecular Complementation Affinity Purification (BiCAP)

    Hastings, J. F., Han, J. Z. R., Shearer, Robert Francis, Kennedy, S. P., Iconomou, M., Saunders, D. N. & Croucher, D. R., 2018, In : Journal of Visualized Experiments. 136, e57109.

    Research output: Contribution to journalJournal articleResearchpeer-review

  77. Published

    EASI-tag enables accurate multiplexed and interference-free MS2-based proteome quantification

    Virreira Winter, S., Meier, F., Wichmann, C., Cox, J., Mann, Matthias & Meissner, F., 2018, In : Nature Methods. 15, 7, p. 527-530 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  78. Published

    ENABLE 2017, the First EUROPEAN PhD and Post-Doc Symposium. Session 3: In Vitro to In Vivo: Modeling Life in 3D

    Di Mauro, G., Dondi, A., Giangreco, G., Hogrebe, A., Louer, E., Magistrati, E., Mullari, Meeli, Turon, G., Verdurmen, W., Cortada, H. X. & Zivanovic, S., 2018, In : Journal of Personalized Medicine. 8, 2, p. 1-5 20.

    Research output: Contribution to journalConference articleResearchpeer-review

  79. Published

    ENABLE 2017, the First EUROPEAN PhD and Post-Doc Symposium. Session 4: From Discovery to Cure: The Future of Therapeutics

    Di Mauro, G., Dondi, A., Giangreco, G., Hogrebe, A., Louer, E., Magistrati, E., Mullari, Meeli, Turon, G., Verdurmen, W., Xicoy Cortada, H. & Zivanovic, S., 2018, In : Medical Sciences. 6, 2, p. 1-6 6 p., 42.

    Research output: Contribution to journalConference articleResearchpeer-review

  80. Published

    ENABLE 2017, the First European PhD and Post-Doc Symposium. Session 1: Building the Foundations of Biology: Synthetic and Cellular Research

    Di Mauro, G., Dondi, A., Giangreco, G., Hogrebe, A., Louer, E., Magistrati, E., Mullari, Meeli, Turon, G., Verdurmen, W., Xicoy Cortada, H. & Zivanovic, S., 2018, In : Biomolecules. 8, 3, p. 1-6 46.

    Research output: Contribution to journalConference articleResearchpeer-review

  81. Published

    ENABLE 2017, the First European PhD and Post-Doc Symposium. Session 2: The OMICS Revolution

    Di Mauro, G., Dondi, A., Giangreco, G., Hogrebe, A., Louer, E., Magistrati, E., Mullari, Meeli, Turon, G., Verdurmen, W., Xicoy Cortada, H. & Zivanovic, S., 2018, In : Biomolecules. 8, 4, p. 1-6 116.

    Research output: Contribution to journalConference articleResearchpeer-review

  82. Published

    Exploring ECD on a Benchtop Q Exactive Orbitrap Mass Spectrometer

    Fort, K. L., Cramer, C. N., Voinov, V. G., Vasil'ev, Y. V., Lopez, N. I., Beckman, J. S. & Heck, A. J. R., 2018, In : Journal of Proteome Research. 17, 2, p. 926-933 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  83. Published

    Extreme disorder in an ultrahigh-affinity protein complex

    Borgia, A., Borgia, M. B., Bugge, Katrine, Kissling, V. M., Heidarsson, P. O., Fernandes, Catarina, Sottini, A., Soranno, A., Buholzer, K. J., Nettels, D., Kragelund, Birthe Brandt, Best, R. B. & Schuler, B., 2018, In : Nature. 555, p. 61-66 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  84. Published

    Future Perspectives on GLP-1 Receptor Agonists and GLP-1/glucagon Receptor Co-agonists in the Treatment of NAFLD

    Seghieri, M., Christensen, A. S., Andersen, A., Solini, A., Knop, Filip Krag & Vilsbøll, Tina, 2018, In : Frontiers in Endocrinology. 9, p. 1-10 649.

    Research output: Contribution to journalReviewResearchpeer-review

  85. Published

    Generic Workflow for Mapping of Complex Disulfide Bonds Using In-Source Reduction and Extracted Ion Chromatograms from Data-Dependent Mass Spectrometry

    Cramer, C. N., Kelstrup, C., Olsen, Jesper Velgaard, Haselmann, K. F. & Nielsen, P. K., 2018, In : Analytical Chemistry. 90, 13, p. 8202-8210

    Research output: Contribution to journalJournal articleResearchpeer-review

  86. Published

    Genome-wide identification of clusters of predicted microRNA binding sites as microRNA sponge candidates

    Pan, X., Wenzel, Anne, Jensen, Lars Juhl & Gorodkin, Jan, 2018, In : PLoS ONE. 13, 8, 15 p., e0202369.

    Research output: Contribution to journalJournal articleResearchpeer-review

  87. Published

    Glucagon receptor signaling in metabolic diseases

    Albrechtsen, Nicolai Jacob Wewer, 2018, In : Peptides. 100, p. 42-47

    Research output: Contribution to journalJournal articleResearchpeer-review

  88. Published

    High-throughput and high-sensitivity phosphoproteomics with the EasyPhos platform

    Humphrey, S. J., Karayel, O., James, D. E. & Mann, Matthias, 2018, In : Nature Protocols (Print). 13, p. 1897-1916 20 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  89. Published

    How do CRISPR-Cas RNA-guided endonucleases cut specific DNA regions for Genome Editing?

    Montoya, Guillermo, 2018, In : Acta Crystallographica Section A: Foundations and Advances. 74, p. E3 1 p.

    Research output: Contribution to journalConference abstract in journalResearch

  90. Published

    How well do force fields capture the strength of salt bridges in proteins?

    Ahmed, Mustapha Carab Hussein, Papaleo, Elena & Lindorff-Larsen, Kresten, 2018, In : PeerJ. 6, 17 p., 4967.

    Research output: Contribution to journalJournal articleResearchpeer-review

  91. Published

    Ibuprofen alters human testicular physiology to produce a state of compensated hypogonadism

    Kristensen, D. M., Desdoits-Lethimonier, C., Mackey, Abigail, Dalgaard, M. D., De Masi, F., Munkbøl, C. H., Styrishave, Bjarne, Antignac, J., Le Bizec, B., Platel, C., Hay-Schmidt, Anders, Jensen, T. K., Lesné, L., Mazaud-Guittot, S., Kristiansen, Karsten, Brunak, Søren, Kjær, Michael, Juul, Anders & Jégou, B., 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 4, p. e715-e724 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  92. Published

    Ibuprofen is deleterious for the development of first trimester human fetal ovary ex vivo

    Leverrier-Penna, S., Mitchell, R. T., Becker, E., Lecante, L., Ben Maamar, M., Homer, N., Lavoue, V., Kristensen, D. M., Dejucq-Rainsford, N., Jegou, B. & Mazaud-Guittot, S., 2018, In : Human Reproduction. 33, 3, p. 482-493

    Research output: Contribution to journalJournal articleResearchpeer-review

  93. Published

    Identifying the druggable interactome of EWS-FLI1 reveals MCL-1 dependent differential sensitivities of Ewing sarcoma cells to apoptosis inducers

    Tsafou, K., Katschnig, A. M., Radic-Sarikas, B., Mutz, C. N., Iljin, K., Schwentner, R., Kauer, M. O., Mühlbacher, K., Aryee, D. N. T., Westergaard, David, Haapa-Paananen, S., Fey, V., Superti-Furga, G., Toretsky, J., Brunak, Søren & Kovar, H., 2018, In : OncoTarget. 9, 57, p. 31018-31031 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  94. Published

    In vivo brain GPCR signaling elucidated by phosphoproteomics

    Liu, J. J., Sharma, K., Zangrandi, L., Chen, C., Humphrey, S. J., Chiu, Y., Spetea, M., Liu-Chen, L., Schwarzer, C. & Mann, Matthias, 2018, In : Science (New York, N.Y.). 360, 6395, p. 1-11

    Research output: Contribution to journalJournal articleResearchpeer-review

  95. Published

    Increase in clinically recorded type 2 diabetes after colectomy

    Jensen, A. B., Sørensen, Thorkild I.A., Pedersen, Oluf Borbye, Jess, T., Brunak, Søren & Allin, Kristine Højgaard, 2018, In : eLife. 7, e37420.

    Research output: Contribution to journalJournal articleResearchpeer-review

  96. Published

    Integrative Characterization of the R6/2 Mouse Model of Huntington's Disease Reveals Dysfunctional Astrocyte Metabolism

    Skotte, Niels Henning, Andersen, Jens Velde, Santos, A., Aldana Garcia, Blanca Irene, Willert, C. W., Nørremølle, Anne, Waagepetersen, Helle S. & Nielsen, Michael Lund, 2018, In : Cell Reports. 23, 7, p. 2211-2224 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  97. Published

    Integrative network analysis highlights biological processes underlying GLP-1 stimulated insulin secretion: A DIRECT study

    Gudmundsdottir, V., Pedersen, H. K., Allebrandt, K. V., Brorsson, C. A., van Leeuwen, N., Banasik, Karina, Mahajan, A., Groves, C. J., van de Bunt, M., Dawed, A. Y., Fritsche, A., Staiger, H., Simonis-Bik, A. M. C., Deelen, J., Kramer, M. H. H., Dietrich, A., Hübschle, T., Willemsen, G., Häring, H., de Geus, E. J. C., Boomsma, D. I., Eekhoff, E. M. W., Ferrer, J., McCarthy, M. I., Pearson, E. R., Gupta, R., Brunak, Søren & 't Hart, L. M., 2018, In : P L o S One. 13, 1, p. 1-19 e0189886.

    Research output: Contribution to journalJournal articleResearchpeer-review

  98. Published

    Interplay Between Long Noncoding RNAs and MicroRNAs in Cancer

    Russo, Francesco, Fiscon, G., Conte, F., Rizzo, M., Paci, P. & Pellegrini, M., 2018, Computational Cell Biology. von Stechow, L. & Delgado, A. S. (eds.). Humana Press, p. 75-92 18 p. (Methods in Molecular Biology, Vol. 1819).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  99. Published

    Large-Scale Phosphoproteomics Reveals Shp-2 Phosphatase-Dependent Regulators of Pdgf Receptor Signaling

    Batth, Tanveer Singh, Papetti, M., Pfeiffer, Anamarija, Tollenaere, M. A. X., Francavilla, C. & Olsen, Jesper Velgaard, 2018, In : Cell Reports. 22, 10, p. 2784-2796 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  100. Published

    Ligand-selective small molecule modulators of the constitutively active vGPCR US28

    Amarandi, R., Lückmann, Michael, Melynis, M., Jakobsen, M. H., Fallah, Z., Spiess, Katja, Hjortø, Gertrud Malene, Pui, A., Frimurer, Thomas Michael & Rosenkilde, Mette, 2018, In : European Journal of Medicinal Chemistry. 155, p. 244-254

    Research output: Contribution to journalJournal articleResearchpeer-review

  101. Published

    Limits for resolving isobaric tandem mass tag reporter ions using phase constrained spectrum deconvolution

    Kelstrup, C. D., Aizikov, K., Batth, Tanveer Singh, Kreutzman, A., Grinfeld, D., Lange, O., Mourad, D., Makarov, A. A. & Olsen, Jesper Velgaard, 2018, In : Journal of Proteome Research. 17, 11, p. 4008-4016 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  102. Published

    MCM2 promotes symmetric inheritance of modified histones during DNA replication

    Petryk, N., Dalby, M., Wenger, Alice, Stromme, C. B., Strandsby, A., Andersson, Robin & Groth, Anja, 2018, In : Science. 361, 6409, p. 1389-1392 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

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