Standardized benchmarking in the quest for orthologs
Research output: Contribution to journal › Journal article › Research › peer-review
- Standardized benchmarking in the quest for orthologs
Final published version, 673 KB, PDF document
Achieving high accuracy in orthology inference is essential for many comparative, evolutionary and functional genomic analyses, yet the true evolutionary history of genes is generally unknown and orthologs are used for very different applications across phyla, requiring different precision-recall trade-offs. As a result, it is difficult to assess the performance of orthology inference methods. Here, we present a community effort to establish standards and an automated web-based service to facilitate orthology benchmarking. Using this service, we characterize 15 well-established inference methods and resources on a battery of 20 different benchmarks. Standardized benchmarking provides a way for users to identify the most effective methods for the problem at hand, sets a minimum requirement for new tools and resources, and guides the development of more accurate orthology inference methods.
|Number of pages||6|
|Publication status||Published - May 2016|
Number of downloads are based on statistics from Google Scholar and www.ku.dk