Quantitative metaproteomics of medieval dental calculus reveals individual oral health status

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Quantitative metaproteomics of medieval dental calculus reveals individual oral health status. / Jersie-Christensen, Rosa R; Lanigan, Liam T; Lyon, David; Mackie, Meaghan; Belstrøm, Daniel; Kelstrup, Christian D; Fotakis, Anna K; Willerslev, Eske; Lynnerup, Niels; Jensen, Lars J; Cappellini, Enrico; Olsen, Jesper V.

In: Nature Communications, Vol. 9, 4744, 2018, p. 1-12.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Jersie-Christensen, RR, Lanigan, LT, Lyon, D, Mackie, M, Belstrøm, D, Kelstrup, CD, Fotakis, AK, Willerslev, E, Lynnerup, N, Jensen, LJ, Cappellini, E & Olsen, JV 2018, 'Quantitative metaproteomics of medieval dental calculus reveals individual oral health status', Nature Communications, vol. 9, 4744, pp. 1-12. https://doi.org/10.1038/s41467-018-07148-3

APA

Jersie-Christensen, R. R., Lanigan, L. T., Lyon, D., Mackie, M., Belstrøm, D., Kelstrup, C. D., ... Olsen, J. V. (2018). Quantitative metaproteomics of medieval dental calculus reveals individual oral health status. Nature Communications, 9, 1-12. [4744]. https://doi.org/10.1038/s41467-018-07148-3

Vancouver

Jersie-Christensen RR, Lanigan LT, Lyon D, Mackie M, Belstrøm D, Kelstrup CD et al. Quantitative metaproteomics of medieval dental calculus reveals individual oral health status. Nature Communications. 2018;9:1-12. 4744. https://doi.org/10.1038/s41467-018-07148-3

Author

Jersie-Christensen, Rosa R ; Lanigan, Liam T ; Lyon, David ; Mackie, Meaghan ; Belstrøm, Daniel ; Kelstrup, Christian D ; Fotakis, Anna K ; Willerslev, Eske ; Lynnerup, Niels ; Jensen, Lars J ; Cappellini, Enrico ; Olsen, Jesper V. / Quantitative metaproteomics of medieval dental calculus reveals individual oral health status. In: Nature Communications. 2018 ; Vol. 9. pp. 1-12.

Bibtex

@article{a20e54d4a8d74a0f89825b9079903d74,
title = "Quantitative metaproteomics of medieval dental calculus reveals individual oral health status",
abstract = "The composition of ancient oral microbiomes has recently become accessible owing to advanced biomolecular methods such as metagenomics and metaproteomics, but the utility of metaproteomics for such analyses is less explored. Here, we use quantitative metaproteomics to characterize the dental calculus associated with the remains of 21 humans retrieved during the archeological excavation of the medieval (ca. 1100-1450 CE) cemetery of Tj{\ae}rby, Denmark. We identify 3671 protein groups, covering 220 bacterial species and 81 genera across all medieval samples. The metaproteome profiles of bacterial and human proteins suggest two distinct groups of archeological remains corresponding to health-predisposed and oral disease-susceptible individuals, which is supported by comparison to the calculus metaproteomes of healthy living individuals. Notably, the groupings identified by metaproteomics are not apparent from the bioarchaeological analysis, illustrating that quantitative metaproteomics has the potential to provide additional levels of molecular information about the oral health status of individuals from archeological contexts.",
author = "Jersie-Christensen, {Rosa R} and Lanigan, {Liam T} and David Lyon and Meaghan Mackie and Daniel Belstr{\o}m and Kelstrup, {Christian D} and Fotakis, {Anna K} and Eske Willerslev and Niels Lynnerup and Jensen, {Lars J} and Enrico Cappellini and Olsen, {Jesper V}",
year = "2018",
doi = "10.1038/s41467-018-07148-3",
language = "English",
volume = "9",
pages = "1--12",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Quantitative metaproteomics of medieval dental calculus reveals individual oral health status

AU - Jersie-Christensen, Rosa R

AU - Lanigan, Liam T

AU - Lyon, David

AU - Mackie, Meaghan

AU - Belstrøm, Daniel

AU - Kelstrup, Christian D

AU - Fotakis, Anna K

AU - Willerslev, Eske

AU - Lynnerup, Niels

AU - Jensen, Lars J

AU - Cappellini, Enrico

AU - Olsen, Jesper V

PY - 2018

Y1 - 2018

N2 - The composition of ancient oral microbiomes has recently become accessible owing to advanced biomolecular methods such as metagenomics and metaproteomics, but the utility of metaproteomics for such analyses is less explored. Here, we use quantitative metaproteomics to characterize the dental calculus associated with the remains of 21 humans retrieved during the archeological excavation of the medieval (ca. 1100-1450 CE) cemetery of Tjærby, Denmark. We identify 3671 protein groups, covering 220 bacterial species and 81 genera across all medieval samples. The metaproteome profiles of bacterial and human proteins suggest two distinct groups of archeological remains corresponding to health-predisposed and oral disease-susceptible individuals, which is supported by comparison to the calculus metaproteomes of healthy living individuals. Notably, the groupings identified by metaproteomics are not apparent from the bioarchaeological analysis, illustrating that quantitative metaproteomics has the potential to provide additional levels of molecular information about the oral health status of individuals from archeological contexts.

AB - The composition of ancient oral microbiomes has recently become accessible owing to advanced biomolecular methods such as metagenomics and metaproteomics, but the utility of metaproteomics for such analyses is less explored. Here, we use quantitative metaproteomics to characterize the dental calculus associated with the remains of 21 humans retrieved during the archeological excavation of the medieval (ca. 1100-1450 CE) cemetery of Tjærby, Denmark. We identify 3671 protein groups, covering 220 bacterial species and 81 genera across all medieval samples. The metaproteome profiles of bacterial and human proteins suggest two distinct groups of archeological remains corresponding to health-predisposed and oral disease-susceptible individuals, which is supported by comparison to the calculus metaproteomes of healthy living individuals. Notably, the groupings identified by metaproteomics are not apparent from the bioarchaeological analysis, illustrating that quantitative metaproteomics has the potential to provide additional levels of molecular information about the oral health status of individuals from archeological contexts.

U2 - 10.1038/s41467-018-07148-3

DO - 10.1038/s41467-018-07148-3

M3 - Journal article

C2 - 30459334

VL - 9

SP - 1

EP - 12

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

M1 - 4744

ER -

ID: 209321135