Disease Systems Biology Program

  1. 2020
  2. Published

    The derived allele of a novel intergenic variant at chromosome 11 associates with lower body mass index and a favorable metabolic phenotype in Greenlanders

    Lepola, Mette Andersen, Jørsboe, Emil, Skotte, L., Hanghøj, Kristian Ebbesen, Sandholt, C. H., Moltke, Ida, Grarup, Niels, Kern, T., Mahendran, Y., Søborg, B., Bjerregaard, P., Larsen, C. V. L., Dahl-Petersen, I. K., Tiwari, H. K., Feenstra, B., Koch, A., Wiener, H. W., Hopkins, S. E., Pedersen, Oluf Borbye, Melbye, Mads, Boyer, B. B., Jørgensen, M. E., Albrechtsen, Anders & Hansen, Torben, 2020, In : PLOS Genetics. 16, 1, 17 p., e1008544.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. E-pub ahead of print

    Proposed new diagnostic criteria for chronic migraine

    Chalmer, M. A., Hansen, Thomas Folkmann, Lebedeva, E. R., Dodick, D. W., Lipton, R. B. & Olesen, Jes, 2020, In : Cephalalgia.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Interpreting pathways to discover cancer driver genes with Moonlight

    Colaprico, A., Olsen, C., Bailey, M. H., Odom, G. J., Terkelsen, T., Silva, T. C., Olsen, A. V., Cantini, L., Zinovyev, A., Barillot, E., Noushmehr, H., Bertoli, G., Castiglioni, I., Cava, C., Bontempi, G., Chen, X. S. & Papaleo, Elena, 2020, In : Nature Communications. 11, 17 p., 69.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Accepted/In press

    Cross-sectional study identifies lower risk of Staphylococcus aureus nasal colonization in Danish blood donors with hidradenitis suppurativa symptoms

    Dinh, K. M., Erikstrup, L. T., Andersen, R. K., Andersen, Paal Skytt, Mikkelsen, S., Kjerulff, B. D., Burgdorf, K. S., Hansen, Thomas Folkmann, Nielsen, K. R., Hjalgrim, H., Jemec, Gregor, Ullum, Henrik, Erikstrup, C. & Pedersen, O. B., 2020, (Accepted/In press) In : British Journal of Dermatology.

    Research output: Contribution to journalLetterResearchpeer-review

  6. Published

    Immune Profiling of Human Gut-Associated Lymphoid Tissue Identifies a Role for Isolated Lymphoid Follicles in Priming of Region-Specific Immunity

    Fenton, T. M., Jørgensen, P. B., Niss, Kristoffer, Rubin, S. J. S., Mörbe, U. M., Riis, Lene Buhl, Da Silva, C., Plumb, A., Vandamme, J., Jakobsen, H. L., Brunak, Søren, Habtezion, A., Nielsen, Ole Haagen, Johansson-Lindbom, B. & Agace, W. W., 2020, In : Immunity. 52, 3, p. 557-570, e1-e6

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. E-pub ahead of print

    JIB.tools 2.0 - A Bioinformatics Registry for Journal Published Tools with Interoperability to bio.tools

    Friedrichs, M., Shoshi, A., Chmura, Piotr Jaroslaw, Ison, J., Schwammle, V., Schreiber, F., Hofestadt, R. & Sommer, B., 2020, In : Journal of integrative bioinformatics. 16, 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Heterogeneity of treatment effect of prophylactic pantoprazole in adult ICU patients: a post hoc analysis of the SUP-ICU trial

    Granholm, A., Marker, S., Krag, M., Zampieri, F. G., Thorsen-Meyer, H., Kaas-Hansen, Benjamin Skov, van der Horst, I. C. C., Lange, Theis, Wetterslev, J., Perner, Anders & Møller, Morten Hylander, 2020, In : Intensive Care Medicine. 46, p. 717–726 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Similar genomic patterns of clinical infective endocarditis and oral isolates of Streptococcus sanguinis and Streptococcus gordonii

    Iversen, Katrine Højholt, Rasmussen, L. H., Al-Nakeeb, K., Armenteros, J. J. A., Jensen, C. S., Dargis, R., Lukjancenko, O., Justesen, U. S., Moser, Claus Ernst, Rosenvinge, F. S., Nielsen, X. C., Christensen, J. J. & Rasmussen, Simon, 17 Feb 2020, In : Scientific Reports. 10, 1, p. 2728

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Conflicting associations between dietary patterns and changes of anthropometric traits across subgroups of middle-aged women and men

    Jiang, L., Audouze, K., Romero Herrera, Jose Alejandro, Ängquist, Lars, Kjærulff, S. K., Izarzugaza, J. M. G., Tjønneland, Anne, Halkjær, J., Overvad, K., Sørensen, Thorkild I.A. & Brunak, Søren, 2020, In : Clinical Nutrition. 39, 1, p. 265-275

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. E-pub ahead of print

    Disease Trajectories for Hidradenitis Suppurativa in the Danish Population

    Kjærsgaard Andersen, R., Jørgensen, Isabella Friis, Reguant, Roc, Jemec, Gregor & Brunak, Søren, 20 May 2020, In : JAMA Dermatology.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    The role of physical activity in metabolic homeostasis before and after the onset of type 2 diabetes: an IMI DIRECT study

    IMI-DIRECT consortium, I. C., Apr 2020, In : Diabetologia. 63, 4, p. 744-756 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Visualize omics data on networks with Omics Visualizer, a Cytoscape App

    Legeay, Marc, Doncheva, Nadezhda Tsankova, Morris, J. H. & Jensen, Lars Juhl, 2020, In : F1000Research. 9, 1 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Comparing 22 Popular Phosphoproteomics Pipelines for Peptide Identification and Site Localization

    Locard-Paulet, Marie, Bouyssié, D., Froment, C., Burlet-Schiltz, O. & Jensen, Lars Juhl, 6 Mar 2020, In : Journal of Proteome Research. 19, 3, p. 1338-1345 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Higher burden of rare frameshift indels in genes related to synaptic transmission separate familial hemiplegic migraine from common types of migraine

    Rasmussen, A. H., Olofsson, I., Chalmer, M. A., Olesen, Jes & Hansen, Thomas Folkmann, 1 Jan 2020, In : Journal of Medical Genetics. 106640.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Combined burden and functional impact tests for cancer driver discovery using DriverPower

    PCAWG Drivers and Functional Interpretation Working Group, P. D. A. F. I. W. G. & PCAWG Consortium, P. C., 2020, In : Nature Communications. 11, 1, 734.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Association between antipsychotic drug dose and length of clinical notes: a proxy of disease severity?

    Sørup, F. K. H., Brunak, Søren & Eriksson, Robert, 7 May 2020, In : BMC Medical Research Methodology. 20, 1, p. 107

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Accepted/In press

    Sex differences in text-mined possible adverse drug events associated with drugs for psychosis

    Sørup, F. K. H., Eriksson, Robert, Westergaard, David, Hallas, J., Brunak, Søren & Andersen, Stig Ejdrup, 1 Jan 2020, (Accepted/In press) In : Journal of Psychopharmacology. 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    CAncer bioMarker Prediction Pipeline (CAMPP) - A standardized framework for the analysis of quantitative biological data

    Terkelsen, T., Krogh, Anders & Papaleo, Elena, 2020, In : PLOS Computational Biology. 16, 3, 20 p., e1007665.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Lipidomic profiles, lipid trajectories and clinical biomarkers in female elite endurance athletes

    V Varga, Tibor, Ali, A., Romero Herrera, Jose Alejandro, Ahonen, L. L., Mattila, I. M., Al-Sari, N. H., Legido-Quigley, C., Skouby, Sven O., Brunak, Søren & Tornberg, Å. B., 2020, In : Scientific Reports. 10, 9 p., 2349.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    A draft genome sequence of the elusive giant squid, Architeuthis dux

    Rodrigues da Fonseca, Rute Andreia, Couto, A., Machado, A. M., Brejova, B., Albertin, C. B., Silva, F., Gardner, P., Baril, T., Hayward, A., Campos, A., Ribeiro, Â. M., Barrio-Hernandez, I., Hoving, H., Tafur-Jimenez, R., Chu, C., Frazão, B., Petersen, Bent, Peñaloza, F., Musacchia, F., Alexander, G. C., Osório, H., Winkelmann, I., Simakov, O., Rasmussen, Simon, Rahman, M. Z., Pisani, D., Vinther, J., Jarvis, E., Zhang, Guojie, Strugnell, J. M., Castro, L. F. C., Fedrigo, O., Patricio, M., Li, Q., Rocha, S., Antunes, A., Wu, Y., Ma, B., Sanges, R., Vinar, T., Blagoev, B., Sicheritz-Pontén, Thomas, Nielsen, Rasmus & Gilbert, M Thomas P, 2020, In : GigaScience. 9, 1, giz152.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. 2019
  23. Published

    The use of systems biology in chemical risk assessment

    Aguayo Orozco, Alejandro, Taboureau, Olivier Thierry & Brunak, Søren, 2019, In : Current Opinion in Toxicology. 15, p. 48-54 7 p.

    Research output: Contribution to journalReviewResearchpeer-review

  24. Published

    sAOP: linking chemical stressors to adverse outcomes pathway networks

    Aguayo Orozco, Alejandro, Audouze, K., Siggaard, T., Barouki, R., Brunak, Søren & Taboureau, Olivier Thierry, 2019, In : Bioinformatics. 2 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations

    Albrecht, W., Kappenberg, F., Brecklinghaus, T., Stoeber, R., Marchan, R., Zhang, M., Ebbert, K., Kirschner, H., Grinberg, M., Leist, M., Moritz, W., Cadenas, C., Ghallab, A., Reinders, J., Vartak, N., van Thriel, C., Golka, K., Tolosa, L., Castell, J. V., Damm, G., Seehofer, D., Lampen, A., Braeuning, A., Buhrke, T., Behr, A., Oberemm, A., Gu, X., Kittana, N., van de Water, B., Kreiling, R., Fayyaz, S., van Aerts, L., Smedsrød, B., Ellinger-Ziegelbauer, H., Steger-Hartmann, T., Gundert-Remy, U., Zeigerer, A., Ullrich, A., Runge, D., Lee, S. M. L., Schiergens, T. S., Kuepfer, L., Aguayo Orozco, Alejandro, Sachinidis, A., Edlund, K., Gardner, I., Rahnenführer, J. & Hengstler, J. G., 2019, In : Archives of Toxicology. 93, 6, p. 1609-1637 29 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    SignalP 5.0 improves signal peptide predictions using deep neural networks

    Armenteros, J. J. A., Tsirigos, Konstantinos, Sønderby, C. K., Petersen, T. N., Winther, Ole, Brunak, Søren, von Heijne, G. & Nielsen, H., 18 Feb 2019, In : Nature Biotechnology. 37, 4, p. 420-423

    Research output: Contribution to journalJournal articleCommunication

  27. Published

    Contaminating viral sequences in high-throughput sequencing viromics: a linkage study of 700 sequencing libraries

    Asplund, M., Kjartansdóttir, K. R., Mollerup, S., Vinner, Lasse, Fridholm, H., Romero Herrera, Jose Alejandro, Friis-Nielsen, J., Hansen, T. A., Jensen, R. H., Nielsen, Ida Broman, Richter, S. R., Rey de la Iglesia, Alba, Matey-Hernandez, M. L., Alquezar-Planas, D. E., Olsen, Pernille Vibeke Selmer, Sicheritz-Pontén, Thomas, Willerslev, Eske, Lund, O., Brunak, Søren, Mourier, T., Nielsen, L. P., Izarzugaza, J. M. G. & Hansen, Anders Johannes, 2019, In : Clinical Microbiology and Infection. 25, 10, p. 1277-1285

    Research output: Contribution to journalJournal articleResearchpeer-review

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