Master project in imaging of genome caretakers - Lukas group

Lukas group is seeking a student to do their master thesis in the group.

The project will focus on delineating exciting aspects of the DNA damage response on the single-cell level, with a particular focus on how chromatin changes induced by DNA double-strand breaks destabilize human genome, and how defects in these mechanisms could predispose to diseases such as cancer. The candidate will be trained by top experts to use advanced imaging techniques and methodologies within cell biology, molecular biology and biochemistry to study genome integrity maintenance in well-characterized cellular models that are ready and available in the Lukas laboratory.

Project’s duration: 6-12 months.

We envisage that suitable candidates for this project are students with a background in Molecular biology, Human biology, Biotechnology, Biochemistry, or related programs.

If you are interested in joining the lab, please send a short motivation letter and your CV, including a list of Master’s grades and Diploma & Bachelor degree grades, to Dr. Susi Bantele ( Please feel free to contact us for more information.

Deadline for application: 01/05/2021.

Selected publications from the lab:
Homology-directed repair protects the replicating genome from metabolic assaults.
Somyajit, K., Spies, J., Coscia, F., Kirik, U., Rask, M., Lee, J.-H., Neelsen, K. J., Mund, A., Jensen, L.J., Paull, T.T., Mann, M. & Lukas, Jiri, 2021, In: Dev Cell. 56(4):461-477.e7.

Equilibrium between nascent and parental MCM proteins protects replicating genomes.
Sedlackova, Hana, Rask, M., Gupta, R., Choudhary, Chuna Ram, Somyajit, K. & Lukas, Jiri, 2020, In : Nature. 587, p. 297-302 34 p.

Stabilization of chromatin topology safeguards genome integrity.
Ochs, F., Karemore, Gopal, Miron, E., Brown, J., Sedlackova, Hana, Rask, M., Lampe, M., Buckle, V., Schermelleh, L., Lukas, Jiri & Lukas, Claudia, 2019, In : Nature. 574, 7779, p. 571-574 4 p.