Mann Group – University of Copenhagen

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CPR > Research > Proteomics > Mann Group

Mann Group

The Mann group - Clinical proteomics, is led by Professor and Program Director Matthias Mann – an international expert in proteomics technology.

Matthias Mann has authored and co-authored more than 500 publications with a total citation count of more than 100,000, making him one of the most highly cited researchers worldwide.

In the Mann group - Clinical Proteomics we will undertake an ambitious new biomedical research programme involving proteomics of blood/plasma for patient phenotyping.

We aim to identify biological markers for diabetes, obesity and other metabolic disorders that can be used to improve diagnosis and develop more individualized therapies. Our eventual goal is to prevent the development of the metabolic syndrome in the first place, by targeted and personalized life style interventions.

The Mann group at CPR works in close collaboration with Prof. Matthias Mann’s group at Max Planck Institute of Biochemistry (http://www.biochem.mpg.de/en/rd/mann). Furthermore, the clinical proteomics group will be tightly integrated with Søren Brunak’s group at the CPR, in areas such as ‘big data’ analysis and electronic health record mining.

Research focus

A primary goal is to discover novel blood protein biomarkers which can be used for diagnosis and possibly prevention of type 2 diabetes, obesity and other metabolic diseases.

Figure 1: Streamlined plasma proteomics workflow

The group will build on its world leading expertise in proteomics technologies and implement a high sensitivity and high accuracy platform to analyze the proteomics of up to 100 individuals per day at great accuracy and depth of coverage. Together with our partners at Steno Diabetes Center, Rigshospitalet, Panum Institute, the Novo Nordisk Foundation Center for Basic Metabolic Research at the University of Copenhagen and elsewhere, we will apply this platform to characterize the blood proteome and how it is associated with known and novel metabolic risk factors for diabetes and cardiovascular disease.

Recent publications

Mass-spectrometric exploration of proteome structure and function
Ruedi Aebersold & Matthias Mann, Nature 537, 347–355 (15 September 2016) doi:10.1038/nature19949