Biophysics Team – University of Copenhagen

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CPR > Research > Protein Structure & Function Program > Protein Production Platform > Biophysics Team

The Biophysics Facility

The Biophysics Facility houses instrumentation for the quantitative characterization of the behavior of biological molecules. The biophysical techniques available at the Facility provide information about the conformation, stability, aggregation status of the proteins and other biomolecules, and about the thermodynamics and/or the kinetics of macromolecular interactions, in particular of proteins with other proteins, or with nucleic acids, or with small molecules. Additionally, we are in charge of a micrOTOF-QII mass spectrometer. 

We are in charge of the maintenance of the instruments, the quality controls of protein samples from both the Prokaryotic and Eukaryotic protein expression platforms and provide user support and guidance with the potential applications of the equipment in the Facility. We can perform experiments for users or schedule training sessions with them to operate the instruments for the collection of high-quality data.

Recent selected publications

Garavís, M., López-Méndez, B., Somaza, A., Oyarzabal, J., Dalvit, C., Villasante, A., Campos-Olivas, R., González, C. (2014). Discovery of selective ligands for telomeric RNA G-quadruplexes (TERRA) through 19F-NMR based fragment screening. ACS Chem. Biol. 9(7):1559-1566. doi: 10.1021/cb500100z.

Stella, S., Molina, R., López-Méndez, B., Juillerat, A., Bertonati, C., Daboussi, F., Campos-Olivas, R., Duchateau, P., Montoya, G. (2014). BuD, a helix-loop-helix DNA-binding domain for genome modification. Acta Crystallogr D Biol. Crystallogr. 70(7):2042-2052. doi: 10.1107/S1399004714011183.

López-Méndez, B.*, Tadeo, X.*, Trigueros, T., Laín, A., Castaño, D., Millet, O. (2009). Structural basis for the aminoacid composition of proteins from halophilic archea. PLoS Biology,  7(12):e1000257. doi: 10.1371/journal.pbio.1000257. *Equal contribution.

Madsen JL, Kroghsbo S, Madsen CB, Pozdnyakova I, Barkholt V, Bøgh KL. The impact of structural integrity and route of administration on the antibody specificity against three cow's milk allergens - a study in Brown Norway rats. Clin Transl Allergy. 2014 Aug 18;4:25. doi: 10.1186/2045-7022-4-25

Wisniewska M, Happonen L, Kahn F, Varjosalo M, Malmström L, Rosenberger G, Karlsson C, Cazzamali G, Pozdnyakova I, Frick IM, Björck L, Streicher W, Malmström J, Wikström M. Functional and Structural Properties of a Novel Protein and Virulence Factor (sHIP) in Streptococcus pyogenes. J Biol Chem. 2014 Jun 27;289(26):18175-88. doi: 10.1074/jbc.M114.565978