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The Genomic History of Denmark
CPR is part of the Cross-Faculty Project Grant entitled ‘The Genomic History of Denmark’ that received 36 million DKK from Univ. of Copenhagen's dedicated 2016-Program. Professor Eske Willerslev from Center for GeoGenetics at Natural History Museum is the principle investigator and coordinator of the grant, in which we will analyze DNA and proteins extracted from a Danish collection of archaeological skeletons from the Older Stone Age (5000-3000 BC) to learn more about the Danish cultural heritage and health history.
A kinase recruiting a phosphatase to the kinetochore:
New insight into how the PP2A phosphatase is recruited to kinetochores:
Important implications for understanding the role of PP2A and BubR1 as tumor suppressors. The study is published in Journal of Cell Science.
Petra Beli recieves Sapere Aude - Postdoc Grant
Congratulations to Petra Beli, who was awarded the Sapere Aude - Postdoc Grant, from The Danish Council of Independent Research (FSS) for her project on ubiquitin-modifying enzymes and their role in DNA damage repair.
Title: Regulation of the cellular response to DNA damage
PhD defense on January 11, 2013
Christian Kelstrup will defend his PhD Thesis: Challenges in Proteomics - Applications and developments.
Locaton: Adolph Hannover Auditorium at PanumFaculty Of Health Sciences, University of Copenhagen, Blegdamsvej 3B,
DK-2200 Copenhagen N
How to get there: Map
New insight into how the temporal degradation of proteins is controlled during mitosis
Orderly progression through mitosis is driven by the degradation of specific proteins at specific times. The Nilsson group provides insight into how this degradation is controlled during mitosis.
World's top protein researchers meet in Denmark at the 2end Copenhagen Bioscience Conferences (CBC): PTMs in cell signaling.
During four intensive days, 15 of the world's most respected protein researchers gave lectures combined with open discussions and short presentations by young, talented researchers.
The Mailand group has discovered a new human protein, DVC1, crucial for protection of genome stability:
The study has establishes the role of DVC1 as an important mediator in the ubiquitin-dependent signaling responses that protect genome stability following replication problems. The study has been published in Nature Structural & Molecular Biology.
Congratulations to Jeremy Daniel
Jeremy Daniel has been awarded the prestigious Sapere Aude grant from The Danish Council for Independent Research (Research Manager) for his pioneering research project, focusing on the understanding of how DNA patterns is generated and controlled during develoment of healthy and cancerous white blood cells.
Congratulations to Chunaram Choudhary
Chunaram Choudhary has been awarded the prestigious Sapere Aude grant from The Danish Council for Independent Research for his research focusing on proteomic analysis of immune and inflammatory signaling.
CPR scientist’s provides new insight into ubiquitylation dynamics:
System-wide analysis reveals a key role for PAF15 ubiquitylation in DNA-damage bypass, an important cellular means of preventing genome instability.
CPR scientist generates new insight into a serious neurodegenerative disease
The study reveals the significance of defects in gene encoding the ATM kinase.
CPR scientists generates organ-wide map of protein acetylation sites in vivo:
The study reveals the significance of lysine acetylations in multiple cellular processes.
New insights into genome integrity maintenance - another piece of the puzzle.
CPR scientists have discovered how two proteins; TRIP12 and UBR5, control that DNA-repair events only occur in the damaged areas of the genome - a pathway that may be subverted during cancer progression. The results of this work have been published in the prestigious journal Cell.
Newsletter no. 15
Newsletter covering the period: 1 October 2011 to 30 June 2012.
Matthias Mann – Körber European Science Prize winner 2012
Congratulations to Matthias Mann who has recieved the Körber European Science Prize 2012 for his ground-breaking work on the proteome using mass spectrometry.
CPR scientists delineate protein phosphorylation sites across 14 different rat tissues and organs.
CPR scientists from department of Proteomics and Diseae System Biology have used high resolution tandem mass spectrometry to generate the broadest tissue catalog of phosphorylated proteins to date.
CPR Scientists study serious immune malfunction
Defects in the gene that encodes the XIAP protein result in a serious immune malfunction. Scientists sheed new light on the underlying signaling pathway. The results have been published in Molecular Cell.
Professor Jiri Lukas elected member of The Royal Danish Academy of Sciences and Letters
At a meeting the 29 March 2012, The Royal Danish Academy of Sciences and Letters elected Professor, Dr. Jiri Lukas a foreign member of the Natural Sciences Class.
Professor, Dr. Jiri Lukas has been appointed new director of CPR
Professor, Dr. Jiri Lukas has been appointed new director of CPR. Read more.
Matthias Mann awarded Louis-Jeantet Prize for Medicine 2012
Professor Matthias Mann from NNF Center for Protein Research and the Max Planck Institute for Biochemistry, Martinsried, Germany, has been awarded the prestigious 2012 Louis-Jeantet Prize for medicine for his work on developments in mass spectrometry that have revolutionized the analysis of proteins and of their functions. The prize amounts to 4.3M DKK, of which 3.8M DKK are to be used for financing ongoing research and 460.000 DKK are given personally.
Congratulations to Matthias Mann who has been awarded the 2012 Leibniz Prize
Professor Matthias Mann from Novo Nordisk Foundation Center for Protein Research and the Max Planck Institute for Biochemistry has been awarded the 2012 Gottfried Wilhelm Leibniz Prize for his development of methods for analysis of proteins using mass spectrometry.
First ancient proteome revealed
The groups of Lars J. Jensen and Jesper V. Olsen of the Novo Nordisk Foundation Center for Protein Research at the University of Copenhagen together with scientists at the Center for GeoGenetics at the Natural History Museum of Denmark and international coworkers used high-sensitivity, high-resolution tandem mass spectrometry to sequence proteins extracted from a 43,000 year old woolly mammoth bone that had been preserved in Siberian permafrost.
CPR Newsletter No. 14
CPR Newsletter No. 14 covering the period 1 April - 30 September 2011. Please click here
Identifying Correlations in Electronic Patient Records
A new study demonstrates how text mining of electronic health records can be used to create medical term profiles of patients, which can be used both to identify co-occurrence of diseases and to cluster patients into groups with highly similar clinical features. The study, carried out in Denmark by a multi-disciplinary group of bioinformaticians, systems biologists and clinicians, will be published in the open-access journal PLoS Computational Biology on 25th August 2011.
Health records contain detailed phenotypic information on the clinical profile of each individual patient; however, a large part of the clinical features are described in free text produced by hospital staff often covering many years of hos...
Peer Bork steps down from the Scientific Advisory Board
CPR regrets to announce that Prof. Peer Bork, Joint Head of the Structural and Computational Biology Unit, EMBL, has stepped down from his position as a member of the Scientific Advisory Board in May 2011. We would like to thank Prof. Bork for his time and valuable contribution to our Scientific Advisory Board. The search for a replacement is ongoing.
Michael Sundström steps down from his position as Managing Director of CPR
Michael Sundström has unfortunately decided to leave his position as Managing Director at the Novo Nordisk Foundation Center for Protein Research at the University of Copenhagen, to assume the position as Vice President, Discovery Research at Karolinska Development in Stockholm from October 1st 2011. In addition to being able to work more in depth with translational research activities, it also allows him to be closer to his family in Stockholm. Michael has been working with the Center fr...
Prof Jesper Olsen awarded the prestigious Sapere Aude Grant
Prof Jesper Olsen, Group Leader in Mass Spectrometry for Quantitative Proteomics, Department of Proteomics, CPR, was awarded a prestigious Sapere Aude: DFF Starting Grant from the Danish Council for Independent Research - Medical Sciences. He receives more than 8 MDKK (1.1 M€) for his project entitled: ‘Phosphoproteomics Tracing of Cancer Therapeutic Drug Effects in Signaling Networks from Tissues and Organs'.
Please visit the DFF homepage to read more (in Danish).
Søren Brunak appointed ISCB Fellow 2011
Professor Søren Brunak receives the prestigious honour of being appointed ISCB Fellow 2011. The ISCB Fellowship award is given for outstanding contributions to the fields of computational biology and bioinformatics and for having demonstrated excellence in research and served the interest of the ISCB Community.
The International Society for Computational Biology appointed four Fellows in 2011 which in addition to professor Brunak includes Michael Ashburner from EMBL-EBI, UK, Philip E. Bourner, University of California, Sa...
CPR researchers quantify thousands of endogenous ubiquitylation sites
CPR researchers quantify thousands of endogenous ubiquitylation sites
Modification of proteins by ubiquitin can serve as a ‘kiss of death' to target proteins for degradation via the proteasome. However, it is clearly emerging that ubiquitin also plays many other important functions in cells. Thus precise mapping of modification sites and their quantification has remained a major challenge.
The Department of Proteomics (Sebastian A. Wagner, Petra Beli, Brian T. Weinert, Michael L. Nielsen, Matthias Mann and Chunaram Choudhary) has in collaboration with the Department of Proteomics and Signal Transduction, Max Planck Institute for Biochemistry, Martinsried, Germany recently published the largest ubiquitylation dataset in human cells to date. In this paper, for the first time, researchers were able to quantify changes in thousands of endogenous ubiquitylation sites in cells treated...
Group Leader - Disease Biology
CPR has recently recruited one group leader to the Department of Disease Biology: Jakob Nilsson from the Biotech Research and Innovation Centre (BRIC), University of Copenhagen. Jakob Nilsson will head the Mitotic Mechanisms and Regulation research group starting 1 August 2011.
Young CPR Scientist Joins the Lindau Meeting
Associate Professor, PhD Simon Bekker-Jensen, Ubiquitin Signaling at CPR has been chosen as one of three representatives from Denmark to attend the 61st Meeting of Nobel Laureates at Lindau, Germany.
CPR Newsletter No. 13
CPR Newsletter No. 13 covering the period 1 January - 31 March 2011 - please click here.
Systems-wide analysis of human stem cell differentiation published in Science Signaling
The Department of Proteomics (Jesper V. Olsen and Matthias Mann) has in collaboration with the group of Associate Prof. Dr. Blagoy Blagoev at the Center for Experimental BioInformatics at the University of Southern Denmark and other international partners published a paper in Science Signaling and made the cover page:
CPR Annual Report 2010
Please download the CPR Annual Report 2010 here (pdf)
Dr Jesper Svejstrup associated as Honorary Professor
Dr Jesper Svejstrup has been associated with the Faculty of Health Sciences as Honorary Professor. He will in this role provide advice regarding research efforts at the Novo Nordisk Foundation Center for Protein Research (CPR) and at the Department of Cellular and Molecular Medicine (ICMM).
CPR Newsletter No. 12
CPR Newsletter No. 12 - covering October - December 2010.Please click here!
Professor Lars Juhl Jensen awarded the Jorck Foundation Prize
13 December 2010: Professor Lars Juhl Jensen awarded the Jorck Foundation Prize
Professor Lars Juhl Jensen awarded The Lundbeck Foundation’s Research Prize for Young Scientists
On 25 January 2011, Professor Lars Juhl Jensen, Group Leader of the Department of Disease Systems Biology, The Novo Nordisk Foundation Center for Protein Research (CPR), is awarded The Lundbeck Foundation's Research Prize for Young Scientists.
Newsletter No. 11
CPR Newsletter No. 11 covering July-September 2010 - please click here!
Prof Niels Mailand awarded prestigious Sapere Aude Starting Grant
Prof Niels Mailand, Group Leader in Ubiquitin Signaling, Department of Disease Biology, CPR, received a Sapere Aude Starting Grant of more than 7 MDKK (1 M€) for his project entitled: ‘Systematic Analysis of Ubiquitin- and SUMO-dependent Signalling Processes in the DNA Damage Response in Human Cells' from the Danish Council for Independent Research - Medical Sciences. Read the project description here (in Danish).
Newsletter No. 10
CPR Newsletter No. 10 covering April-June 2010 - please click here!
Networks involved in heart diseases resemble Facebook
The heart is formed through networks of communicating genes. These molecular networks have now been mapped for the first time, and they resemble social networks found on Facebook. This surprising discovery is reported by an international research group lead by Danish researchers, and will influence our understanding of heart diseases and several other diseases such as schizophrenia, autism and dementia. In addition the results could pave the way for new treatments like stem cell therapy.
Prof. Ivan Dikic joins the Scientific Advisory Board
CPR is pleased to announce that Prof. Ivan Dikic, Director of the Institute of Biochemistry II, Goethe University Medical School, Frankfurt am Main (Germany), has accepted to join the Scientific Advisory Board. Prof. Dikic studies signaling pathways that control cell growth and differentiation with a special interest in the role of ubiquitin and ubiquitin-like modifiers. Prof. Dikic will add great value to the work of the Scientific Advisory Board.
Vilhelm Bohr steps down from the Scientific Advisory Board
CPR would like to thank Prof. Vilhelm Bohr, Senior Investigator and Chief, Laboratory of Molecular Gerontology, National Institute on Aging, NIH, Baltimore (US), for his important contributions in the Scientific Advisory Board. Prof. Bohr stepped down from his position as a member of the Scientific Advisory Board in May, 2010.
CPR Annual Report 2009
Please download the CPR Annual Report 2009 here! (pdf)
Newsletter No. 9
Covering December 2009 - March 2010.
CPR scientists contribute features of ancient human
Nature, 11 February 2010: The genome of a man who lived on the western coast of Greenland 4,000 years ago has been decoded, thanks to the surprisingly good preservation of DNA in a swatch of his hair. This is the first time the whole genome of an ancient human has been analyzed. Scientists from CPR contributed the calling of many of the traits.
Young CPR Scientist Awarded
Assoc. Prof. Simon Bekker-Jensen, Ubiquitin Signaling Group awarded the Danish Independent Research Council's Young Researcher's Award.
First large-scale inter-departmental collaboration study at CPR has been published
The Department of Proteomics (Jesper V. Olsen and Matthias Mann) has in collaboration with the Department of Disease Systems Biology (Lars Juhl Jensen, Martin L. Miller and Søren Brunak) and other international partners published a paper in Science Signaling.
Cézanne's Garden - art at CPR
The Danish artist Erik Steffensen is behind the decoration of the Novo Nordisk Foundation Center for Protein Research.
Prof Niels Mailand receives The Lundbeck Foundation's Award for Younger Scientists 2009
Prof Niels Mailand, Group Leader of The Department of Disease Biology, CPR, received The Lundbeck Foundation's Award for Younger Scientists on 8 December 2009.
CPR Community Target Committee
The Novo Nordisk Foundation Center for Protein Research will from early 2010 dedicate resources within the areas of Protein Production and Characterization as well as Chemical Biology (screening and validation of protein binders vs. recombinant protein samples) to external collaborative projects. We have therefore established a Community Target Committee (CTC) consisting of key scientists from Denmark and Lund University to help us evaluate and prioritize such proposals.
Pernille Rørth joins the CPR Scientific Advisory Board
CPR is pleased to announce that Prof. Pernille Rørth, PhD, Deputy Director, Institute of Molecular and Cell Biology, A-STAR, Singapore and Research Director of the laboratory "Dynamics of Collective Cell Migration" has accepted to join the Scientific Advisory Board.
The Center will assign dedicated resources within protein production and characterization as well as chemical biology to external collaborative projects starting in 2010.
Visiting Scientist Programme
The Visiting Scientist programme is launched in 2010 within our Protein Science and Technology organization, in which capabilities for high throughput protein production and characterization as well as chemical biology resources are available.
Core Facility to Facility for Protein Science and Technology
Re-organization Protein Science and Technology
The former Biotechnology Unit was re-organized in early October 2009 to achieve clearer focus on its main deliverables...
CPR Newletter No. 8
CPR Newsletter No. 8 - covering August-November 2009.
Torben Ørntoft joins the Scientific Advisory Board
CPR is pleased to announce that Prof. Torben Falck Ørntoft MD, PhD, Head of Department of Molecular Medicine, Aarhus University Hospital at Skejby, Denmark, has accepted to join the Scientific Advisory Board.
Erkki Ruoslahti steps down from the Scientific Advisory Board.
CPR would like to thank Prof. Erkki Ruoslahti, Distinguished Professor at the Burnham Institute for Medical Research, La Jolla (US), for his important contributions in the Scientific Advisory Board. Prof. Ruoslahti stepped down from his position as a member of the Scientific Advisory Board in October, 2009.
Professor Søren Brunak awarded The Grundfos Prize 2009
29 September 2009: Center Director, professor Søren Brunak awarded The Grundfos Prize 2009.
Newsletter No. 7
Please click here for CPR Newsletter No. 7 - covering May-July 2009.
Researchers identify important molecular disease-switches in humans
Science, 16 July 2009: Proteins, the molecules of life, are not only the building blocks of living organisms; they also serve as work crews that perform most essential functions of life. A specific protein can perform more than one task, and how it acts in our body can be regulated by adding small molecules to it, which then act as "switches" for various tasks.
Please click here for more information!
4 June 2009: New Protein Center Opens
On the 4th June, the Faculty of Health Sciences at the University of Copenhagen will open the doors of its new research center, The Novo Nordisk Foundation Center for Protein Research. The Center is the result of a historic donation from the Novo Nordisk Foundation, which in 2007 gave the University 80 million euros for its establishment.
Press release - please click here!
Group Leaders, Disease Biology
28 March 2009: CPR has recently recruited two group leaders to the Disease Biology efforts: Amilcar Flores Morales from the Karolinska Institute and Niels Mailand from the Danish Cancer Society. Both will assume their positions at the Center in the summer 2009. Please click here for more information.
CPR Newsletter No. 6
Newsletter no. 6 covering December 2008 - April 2009.
CPR Newsletter No. 5
Newsletter No. 5 from NNF Center for Protein Research - covering September-November 2008.
Comprehensive mass-spectrometry-based proteome quantification of haploid versus diploid yeast
Nature, 28 Sept 2008: The proteome of a cell is the totality of all expressed proteins in a given condition. Unlike the static genome, the proteome is highly dynamic and can be used to decipher the inner working of cellular processes. Despite decades of effort, no complete proteome has yet been measured. Now, using a combination of mass spectrometry with other high technology tools, a team around Prof. Jesper V. Olsen and Prof. Matthias Mann of the Max-Planck Institute for Biochemistry and the Novo Nordisk Foundatio...
Proteomics Ponders Prime Time
Newsfocus in Science with comments by Department Head, Matthias Mann.
"Improved technologies for tracking thousands of proteins at once have spawned talk of a full-scale project to reveal all the proteins in each tissue".
A pilot project to generate affinity reagents to human proteins
- correspondance in Nature Methods.
"A pilot study to generate - in a decentralized and coordinated manner - protein binders to the human SH2-containing proteins"
Selected Press Cuttings
Click here for selected press cuttings (English, Danish, Swedish).
Newsletter No. 4
The Novo Nordisk Foundation Center for Protein Research is in the process of being established at the Faculty of Health Sciences, University of Copenhagen, to promote basic and applied discovery research on human proteins of medical relevance...
An international collaboration on generating affinity reagents towards human proteins has been launched.
Newsletter No. 3
February 1st to April 30th 2008
The Novo Nordisk Foundation Center for Protein Research is in the process of being established at the Faculty of Health Sciences, University of Copenhagen, to promote basic and applied discovery research on human proteins of medical relevance.
Newsletter No. 2
October 2007 - January 2008
The Novo Nordisk Foundation Center for Protein Research is in the process of being established at the Faculty of Health Sciences, University of Copenhagen, to promote basic and applied discovery research on human proteins of medical relevance. This major development has been made possible through a generous donation of 600 MDKK from the Novo Nordisk Foundation, being one of the largest single investments in the life sciences in Denmark (http://www.cpr.ku.dk/).
Newsletter No. 1
To all staff
On 30th April, the Faculty of Health Sciences (SUND) received a magnificent donation of DKK 600m from the Novo Nordisk Foundation to set up and operate a Protein Research Center for the next ten years. The name of the Center is: The Novo Nordisk Foundation Center for Protein Research. The Dean and the Novo Nordisk Foundation had called a press conference for 11.00 a.m....
Management of Protein Research Center
It was 43-year old Michael Sundström, who was appointed the top position at the new research centre in Copenhagen. As Managing Director he will head the significant concentration of strategic efforts within protein research...
The Novo Nordisk Foundation Centre for Protein Research
In early 2009, a new research centre will be opened at the Faculty of Health Sciences. The Novo Nordisk Foundation Center for Protein Research will house a Core Facility for Biotechnology and Biology...