CPR Seminar by David Barford – University of Copenhagen

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CPR > Events > 2017 > David Barford

CPR Seminar by David Barford

Research seminar by David Barford, Structural Studies Division, MRC Laboratory of Molecular Biology, Cambridge, UK.

Title of seminar: "Structural basis for the regulation of the APC/C in mitosis"

The focus of the Barford lab is the anaphase-promoting complex (APC/C), a large multi-subunit complex (~1.2 MDa) that functions to regulate cell cycle transitions, specifically the metaphase to anaphase transition in mitosis (when duplicated sister chromatid pairs are separated), the exit from mitosis and maintenance of G1. 
The aims of our research are to understand the molecular mechanisms underlying the assembly of the APC/C complex, its capacity to recognize and ubiquitinate proteins in a cell cycle-coordinated manner, and the structural basis for its control by the spindle assembly checkpoint. To pursue these aims we use a combination of protein crystallography and single particle cryo-electron microscopy of defined reconstituted complexes.

Read more about David Barford's research here.

Host: Guillermo Montoya is hosting the seminar as part of the CoLuAa XXV 2017 Conference.

All are welcome. Registration is not necessary.