CPR > External Collaborations

External Collaborations

The Center is actively engaged in a number of strategic collaborations to further our research efforts. Among those are the following:

Kinase Inhibitor Profiling (University of Oxford)
Collaboration with University of Oxford and Prof. Stefan Knapp, on comparative analysis of interactions of e.g. inhibitors as a consequence of regulatory domains as compared to only catalytic domains. One CPR PhD student currently works at Oxford to generate a massive amount of protein samples in both forms, for this study.

Chemical Screening Collaboration (NCGC, NIH)
Initiated in 2010, this collaboration with the NIH Chemical Genomics Center (Maryland) aims to identify low molecular weight (LMW) bioprobes, which can be used in subsequent functional studies of protein function. The NCGC possesses a screening library of around 400.000 compounds and sophisticated assay set-up.

3rd Generation Research Database (University of Oxford and Molsoft)
Work has been ongoing since early 2009, to integrate a research database, electronic notebook and informatics tools in one single application (ICM). The work is a collaboration with the University of Oxford and Molsoft LLC (San Diego).

Protein Modifications and Property Profiling (University of Copenhagen and Novo Nordisk)
A systematic study has been initiated, targeting a number of model proteins and more biologically interesting proteins which are systematically subjected to property changes, to comparatively analyse their physical and pharmaceutical properties. This is a collaboration between the Center, the Faculty of Life Sciences (LIFE) and the Faculty of Pharmaceutical Sciences (FARMA) at the University of Copenhagen and Novo Nordisk.

Novel E. coli expression systems (Karolinska Institute)
Two novel expression systems have been developed as part of this collaboration which ended in Dec 2009, for secreted and polycistronic expression. Both studies have been concluded highly successfully. One or possibly two additional collaborative projects will be initiated in 2010 (ligand supplementation and IMP co-expression).

RIKEN, SSBC (Yokohama, Japan), cell-free protein expression
Collaborative effort initiated in March 2010, to compare cell-free (analytical scale) and cell-based protein expression methods using E. coli, S2 Drosophila and HEK293 cells and cell-free translation machineries. A CPR scientist will work at the RIKEN laboratories for 3 months from April 2010.

Poul Nissen laboratory, University of Aarhus
Collaboration started in March 2010 to set-up a parallel and minituarized test-expression system for mammalian protein expression. A CPR scientist will work in the Nissen laboratory for 3-4 months as a joint effort.

National Center for Drug Screening (Shanghai)
A group of scientists at the NCDS is from March 1st, 2010, generating chemical bioprobes to target proteins involved in epigenetic regulation.

Karolinska Institute, SGC (Stockholm)
A new postdoc collaborative project was started on March 17th, 2010, targeting expression of integral membrane proteins, using co-expression strategies.

Renewable Affinity Binders Pilot Project
The purpose of the study is to investigate the relative merits of different approaches, evaluate the quality, affinity and selectivity of both monoclonals and recombinantly produced antibodies as well as to provide an estimate of the economical parameters, should this project be expanded to cover a larger proportion of the human proteome. Currently, nine research groups in Europe, Asia, Australia and in the US are participating, generating binders to a set of 22 SH2 domain containing proteins. The CPR will, at a later stage, work to evaluate binding affinities/selectivity as well as overall quality parameters for these binders.

For more information on the project, please click here.